ENSG00000171105

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341500 ENSG00000171105 HEK293_OSMI2_2hA HEK293_TMG_2hB INSR protein_coding protein_coding 4.835416 3.722967 5.893546 0.127782 0.1851063 0.6612591 4.2817219 3.539191 4.077848 0.05826836 0.07150535 0.2038515 0.90103750 0.9517667 0.6928333 -0.2589333 5.943001e-09 5.538187e-15 FALSE TRUE
ENST00000593970 ENSG00000171105 HEK293_OSMI2_2hA HEK293_TMG_2hB INSR protein_coding retained_intron 4.835416 3.722967 5.893546 0.127782 0.1851063 0.6612591 0.3998266 0.000000 1.620711 0.00000000 0.22508391 7.3493570 0.06510417 0.0000000 0.2738000 0.2738000 5.538187e-15 5.538187e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171105 E001 0.1482932 0.0415039397 4.314507e-01   19 7112255 7112264 10 - 0.000 0.148 9.452
ENSG00000171105 E002 652.8413324 0.0088880474 4.849292e-15 1.670942e-13 19 7112265 7117410 5146 - 2.630 2.972 1.138
ENSG00000171105 E003 41.8290394 0.0004990646 1.513419e-01 2.634936e-01 19 7119449 7119583 135 - 1.601 1.662 0.206
ENSG00000171105 E004 35.4030680 0.0006336101 8.452505e-02 1.666356e-01 19 7120620 7120749 130 - 1.541 1.577 0.123
ENSG00000171105 E005 0.0000000       19 7122570 7122613 44 -      
ENSG00000171105 E006 39.4572143 0.0005345540 1.398722e-04 7.030237e-04 19 7122614 7122773 160 - 1.636 1.562 -0.252
ENSG00000171105 E007 30.4707871 0.0006803839 2.658766e-03 9.249242e-03 19 7122879 7122989 111 - 1.517 1.465 -0.181
ENSG00000171105 E008 0.0000000       19 7122990 7123158 169 -      
ENSG00000171105 E009 48.5109342 0.0004466465 1.733575e-03 6.388636e-03 19 7125283 7125527 245 - 1.699 1.681 -0.063
ENSG00000171105 E010 18.9302282 0.0208672225 3.976271e-02 9.058462e-02 19 7126584 7126651 68 - 1.327 1.250 -0.272
ENSG00000171105 E011 17.1961324 0.0021792517 8.891055e-02 1.734565e-01 19 7128852 7128954 103 - 1.258 1.249 -0.032
ENSG00000171105 E012 21.6976859 0.0010036145 2.963139e-01 4.375183e-01 19 7132158 7132317 160 - 1.327 1.385 0.201
ENSG00000171105 E013 0.2987644 0.0273302227 2.395636e-01   19 7141510 7141676 167 - 0.182 0.000 -12.671
ENSG00000171105 E014 26.8084240 0.0028813098 2.641520e-01 4.020983e-01 19 7141677 7141816 140 - 1.418 1.476 0.202
ENSG00000171105 E015 42.0339921 0.0006807939 1.927798e-02 4.993923e-02 19 7142816 7143090 275 - 1.623 1.634 0.037
ENSG00000171105 E016 0.9222279 0.0136968632 8.785418e-01 9.259882e-01 19 7150497 7150532 36 - 0.250 0.347 0.652
ENSG00000171105 E017 0.2955422 0.0294313406 9.271583e-01   19 7151971 7152725 755 - 0.100 0.148 0.651
ENSG00000171105 E018 33.6644072 0.0006702601 1.584908e-01 2.731066e-01 19 7152726 7152927 202 - 1.510 1.563 0.178
ENSG00000171105 E019 0.5848540 0.0438104180 6.777749e-02 1.396766e-01 19 7159423 7159645 223 - 0.000 0.348 13.242
ENSG00000171105 E020 34.2323269 0.0006235104 2.158091e-01 3.453773e-01 19 7163032 7163199 168 - 1.517 1.581 0.218
ENSG00000171105 E021 39.5486004 0.0005900006 1.957305e-04 9.456190e-04 19 7166154 7166404 251 - 1.636 1.567 -0.236
ENSG00000171105 E022 23.5120901 0.0008344132 2.397291e-06 1.833076e-05 19 7167968 7168094 127 - 1.467 1.259 -0.722
ENSG00000171105 E023 30.6411973 0.0228821524 1.550674e-03 5.800010e-03 19 7170537 7170751 215 - 1.562 1.398 -0.564
ENSG00000171105 E024 28.0995547 0.0110920569 1.279945e-03 4.910027e-03 19 7172290 7172434 145 - 1.510 1.379 -0.453
ENSG00000171105 E025 28.3059431 0.0018947553 1.058868e-05 6.997806e-05 19 7174583 7174731 149 - 1.528 1.363 -0.569
ENSG00000171105 E026 43.9786401 0.0026105952 2.148018e-10 3.577771e-09 19 7184316 7184637 322 - 1.734 1.495 -0.813
ENSG00000171105 E027 63.3066689 0.0006417964 3.791843e-11 7.179944e-10 19 7267345 7267896 552 - 1.867 1.706 -0.545
ENSG00000171105 E028 13.8442838 0.0597575906 2.404882e-02 5.991455e-02 19 7293792 7294414 623 - 1.239 1.052 -0.669