ENSG00000171100

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370396 ENSG00000171100 HEK293_OSMI2_2hA HEK293_TMG_2hB MTM1 protein_coding protein_coding 3.692819 1.617892 5.743411 0.07374169 0.3161483 1.821412 3.04297688 1.0260214 5.102313 0.05056025 0.29128326 2.302922 0.764875000 0.63976667 0.88820000 0.24843333 5.413816e-04 5.955464e-08 FALSE TRUE
ENST00000684910 ENSG00000171100 HEK293_OSMI2_2hA HEK293_TMG_2hB MTM1 protein_coding nonsense_mediated_decay 3.692819 1.617892 5.743411 0.07374169 0.3161483 1.821412 0.01509529 0.1207623 0.000000 0.12076234 0.00000000 -3.708875 0.008704167 0.06963333 0.00000000 -0.06963333 4.923036e-01 5.955464e-08 FALSE TRUE
ENST00000687365 ENSG00000171100 HEK293_OSMI2_2hA HEK293_TMG_2hB MTM1 protein_coding retained_intron 3.692819 1.617892 5.743411 0.07374169 0.3161483 1.821412 0.16444880 0.3258448 0.128610 0.02060666 0.01708681 -1.276763 0.069820833 0.20203333 0.02233333 -0.17970000 5.955464e-08 5.955464e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171100 E001 0.0000000       X 150568417 150568475 59 +      
ENSG00000171100 E002 0.0000000       X 150568582 150568589 8 +      
ENSG00000171100 E003 0.0000000       X 150568590 150568594 5 +      
ENSG00000171100 E004 0.0000000       X 150568595 150568596 2 +      
ENSG00000171100 E005 0.0000000       X 150568597 150568599 3 +      
ENSG00000171100 E006 0.0000000       X 150568600 150568601 2 +      
ENSG00000171100 E007 0.2934659 0.0286272741 2.916776e-01   X 150568602 150568610 9 + 0.062 0.227 2.156
ENSG00000171100 E008 0.2934659 0.0286272741 2.916776e-01   X 150568611 150568611 1 + 0.062 0.227 2.156
ENSG00000171100 E009 0.5964967 0.0249398907 7.662535e-01 8.488056e-01 X 150568612 150568617 6 + 0.165 0.227 0.571
ENSG00000171100 E010 0.8868421 0.0323872339 9.086114e-01 9.459299e-01 X 150568618 150568620 3 + 0.248 0.227 -0.166
ENSG00000171100 E011 1.0340911 0.0121989077 7.516954e-01 8.380793e-01 X 150568621 150568621 1 + 0.284 0.227 -0.427
ENSG00000171100 E012 1.5082172 0.0091325470 9.397950e-01 9.661877e-01 X 150568622 150568624 3 + 0.349 0.376 0.158
ENSG00000171100 E013 2.8659512 0.0054221985 7.143605e-01 8.105971e-01 X 150568625 150568633 9 + 0.540 0.486 -0.256
ENSG00000171100 E014 3.3035456 0.0063149939 5.073461e-01 6.429194e-01 X 150568634 150568638 5 + 0.594 0.486 -0.504
ENSG00000171100 E015 6.3681505 0.0027350789 4.006458e-01 5.443244e-01 X 150568639 150568652 14 + 0.761 0.896 0.527
ENSG00000171100 E016 8.0405686 0.0022046996 4.729475e-01 6.119632e-01 X 150568653 150568662 10 + 0.855 0.966 0.422
ENSG00000171100 E017 0.0000000       X 150568663 150568676 14 +      
ENSG00000171100 E018 0.1482932 0.0410883067 9.872414e-02   X 150568677 150568718 42 + 0.000 0.227 12.997
ENSG00000171100 E019 0.1482932 0.0410883067 9.872414e-02   X 150568730 150568737 8 + 0.000 0.227 12.997
ENSG00000171100 E020 0.1482932 0.0410883067 9.872414e-02   X 150568738 150568743 6 + 0.000 0.227 12.997
ENSG00000171100 E021 0.1482932 0.0410883067 9.872414e-02   X 150568744 150568862 119 + 0.000 0.227 12.997
ENSG00000171100 E022 0.1482932 0.0410883067 9.872414e-02   X 150568863 150568866 4 + 0.000 0.227 12.997
ENSG00000171100 E023 8.9294725 0.0019840756 3.066419e-01 4.488290e-01 X 150592605 150592607 3 + 0.882 1.027 0.540
ENSG00000171100 E024 16.0520545 0.0011840004 7.286646e-01 8.210706e-01 X 150592608 150592677 70 + 1.134 1.189 0.194
ENSG00000171100 E025 10.8429938 0.0015946617 9.211319e-01 9.542284e-01 X 150596498 150596498 1 + 0.990 0.997 0.027
ENSG00000171100 E026 20.1764391 0.0009407046 6.286527e-01 7.441590e-01 X 150596499 150596570 72 + 1.250 1.226 -0.086
ENSG00000171100 E027 0.0000000       X 150596571 150596993 423 +      
ENSG00000171100 E028 21.6179368 0.0010963767 1.809028e-01 3.023510e-01 X 150598592 150598675 84 + 1.293 1.189 -0.368
ENSG00000171100 E029 12.0284772 0.0017672495 6.644415e-02 1.374632e-01 X 150598676 150598686 11 + 1.071 0.857 -0.800
ENSG00000171100 E030 0.3268771 0.0285370913 2.898873e-01   X 150598687 150600125 1439 + 0.062 0.227 2.160
ENSG00000171100 E031 0.2934659 0.0286272741 2.916776e-01   X 150601463 150601507 45 + 0.062 0.227 2.156
ENSG00000171100 E032 0.0000000       X 150612411 150612663 253 +      
ENSG00000171100 E033 26.8276408 0.0007847917 1.241320e-01 2.258807e-01 X 150614589 150614699 111 + 1.385 1.276 -0.379
ENSG00000171100 E034 20.5912460 0.0009155711 3.793592e-01 5.236204e-01 X 150619038 150619087 50 + 1.268 1.207 -0.215
ENSG00000171100 E035 17.6747224 0.0030739793 1.271265e-01 2.301405e-01 X 150619088 150619139 52 + 1.219 1.079 -0.501
ENSG00000171100 E036 6.0827141 0.0029125099 4.278368e-14 1.281866e-12 X 150619140 150620051 912 + 0.349 1.306 3.965
ENSG00000171100 E037 0.0000000       X 150637651 150637720 70 +      
ENSG00000171100 E038 0.2214452 0.0401920071 9.742026e-02   X 150638606 150638761 156 + 0.000 0.228 13.008
ENSG00000171100 E039 19.8945233 0.0189326179 3.395323e-02 7.966334e-02 X 150638943 150639026 84 + 1.283 1.050 -0.829
ENSG00000171100 E040 0.0000000       X 150639726 150640398 673 +      
ENSG00000171100 E041 0.0000000       X 150640399 150640454 56 +      
ENSG00000171100 E042 0.0000000       X 150640455 150641138 684 +      
ENSG00000171100 E043 0.0000000       X 150641139 150641268 130 +      
ENSG00000171100 E044 30.7159362 0.0026044529 7.146573e-03 2.160428e-02 X 150641269 150641418 150 + 1.454 1.243 -0.732
ENSG00000171100 E045 34.1675005 0.0010753069 2.402253e-04 1.134205e-03 X 150645683 150645871 189 + 1.509 1.226 -0.983
ENSG00000171100 E046 22.0150012 0.0170148690 1.704982e-02 4.504619e-02 X 150649716 150649776 61 + 1.325 1.054 -0.964
ENSG00000171100 E047 29.0009042 0.0006752278 4.374018e-02 9.791496e-02 X 150649777 150649901 125 + 1.422 1.276 -0.507
ENSG00000171100 E048 38.8746410 0.0005456377 3.552236e-01 4.995883e-01 X 150657821 150658027 207 + 1.527 1.485 -0.143
ENSG00000171100 E049 10.6119967 0.0016570629 9.666950e-01 9.831142e-01 X 150659664 150659670 7 + 0.983 0.997 0.052
ENSG00000171100 E050 20.6849929 0.0010718377 9.145973e-01 9.499533e-01 X 150659671 150659756 86 + 1.246 1.276 0.105
ENSG00000171100 E051 24.9788137 0.0300034947 2.220422e-01 3.528499e-01 X 150660371 150660484 114 + 1.356 1.226 -0.454
ENSG00000171100 E052 3.0020249 0.1029587165 7.966371e-01 8.702200e-01 X 150660485 150663432 2948 + 0.540 0.491 -0.237
ENSG00000171100 E053 28.7559683 0.0041519955 6.102476e-01 7.296005e-01 X 150663433 150663609 177 + 1.396 1.374 -0.073
ENSG00000171100 E054 14.4413305 0.0012508100 5.406645e-01 6.717644e-01 X 150671428 150671430 3 + 1.125 1.079 -0.164
ENSG00000171100 E055 130.8884180 0.0034545184 7.959559e-11 1.428491e-09 X 150671431 150673143 1713 + 1.965 2.226 0.875