ENSG00000171084

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000467239 ENSG00000171084 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM86JP transcribed_unprocessed_pseudogene processed_transcript 1.822157 2.494573 1.450398 0.152785 0.03090352 -0.7782032 0.32698592 0.7548281 0.00000000 0.37742202 0.00000000 -6.25706367 0.183912500 0.32230000 0.0000000 -0.32230000 2.507590e-01 5.956311e-07   FALSE
ENST00000485843 ENSG00000171084 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM86JP transcribed_unprocessed_pseudogene processed_transcript 1.822157 2.494573 1.450398 0.152785 0.03090352 -0.7782032 0.42514652 0.6252560 0.52840885 0.32440468 0.27167213 -0.23863607 0.216554167 0.24256667 0.3593333 0.11676667 9.214553e-01 5.956311e-07 TRUE FALSE
ENST00000685585 ENSG00000171084 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM86JP transcribed_unprocessed_pseudogene processed_transcript 1.822157 2.494573 1.450398 0.152785 0.03090352 -0.7782032 0.02566046 0.2052837 0.00000000 0.20528369 0.00000000 -4.42816711 0.009166667 0.07333333 0.0000000 -0.07333333 8.249738e-01 5.956311e-07 FALSE FALSE
ENST00000688271 ENSG00000171084 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM86JP transcribed_unprocessed_pseudogene processed_transcript 1.822157 2.494573 1.450398 0.152785 0.03090352 -0.7782032 0.05085846 0.1598331 0.24703461 0.15983305 0.12352546 0.59784540 0.030216667 0.06770000 0.1740333 0.10633333 5.797052e-01 5.956311e-07 FALSE FALSE
ENST00000689246 ENSG00000171084 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM86JP transcribed_unprocessed_pseudogene processed_transcript 1.822157 2.494573 1.450398 0.152785 0.03090352 -0.7782032 0.16092970 0.1213240 0.02903215 0.06244090 0.02903215 -1.75039525 0.092770833 0.04716667 0.0192000 -0.02796667 7.106542e-01 5.956311e-07 FALSE TRUE
ENST00000690857 ENSG00000171084 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM86JP transcribed_unprocessed_pseudogene processed_transcript 1.822157 2.494573 1.450398 0.152785 0.03090352 -0.7782032 0.08172468 0.0000000 0.29176750 0.00000000 0.07210805 4.91536552 0.048591667 0.00000000 0.1993000 0.19930000 5.956311e-07 5.956311e-07 FALSE FALSE
ENST00000691323 ENSG00000171084 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM86JP transcribed_unprocessed_pseudogene processed_transcript 1.822157 2.494573 1.450398 0.152785 0.03090352 -0.7782032 0.11618410 0.1944013 0.06163532 0.09205869 0.06163532 -1.51266149 0.065995833 0.07420000 0.0434000 -0.03080000 6.309776e-01 5.956311e-07   FALSE
ENST00000693592 ENSG00000171084 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM86JP transcribed_unprocessed_pseudogene processed_transcript 1.822157 2.494573 1.450398 0.152785 0.03090352 -0.7782032 0.14633429 0.0000000 0.06006599 0.00000000 0.06006599 2.80871429 0.086620833 0.00000000 0.0423000 0.04230000 6.887181e-01 5.956311e-07 FALSE FALSE
ENST00000693742 ENSG00000171084 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM86JP transcribed_unprocessed_pseudogene processed_transcript 1.822157 2.494573 1.450398 0.152785 0.03090352 -0.7782032 0.23393647 0.2099939 0.19911768 0.07026898 0.09462272 -0.07314847 0.136795833 0.08153333 0.1389667 0.05743333 7.564899e-01 5.956311e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171084 E001 0.4439371 0.021755372 0.0284654994 0.068943972 3 125916609 125916614 6 + 0.354 0.000 -11.148
ENSG00000171084 E002 0.7771569 0.015779205 0.0498050258 0.108813229 3 125916615 125916618 4 + 0.428 0.098 -2.733
ENSG00000171084 E003 0.7771569 0.015779205 0.0498050258 0.108813229 3 125916619 125916619 1 + 0.428 0.098 -2.733
ENSG00000171084 E004 1.4393170 0.009323286 0.0709264699 0.144879044 3 125916620 125916623 4 + 0.546 0.245 -1.733
ENSG00000171084 E005 1.4393170 0.009323286 0.0709264699 0.144879044 3 125916624 125916624 1 + 0.546 0.245 -1.733
ENSG00000171084 E006 3.8728655 0.004500533 0.5071250384 0.642729765 3 125916625 125916678 54 + 0.716 0.632 -0.354
ENSG00000171084 E007 4.1652872 0.004218469 0.2507378803 0.386809833 3 125916679 125916717 39 + 0.781 0.632 -0.617
ENSG00000171084 E008 3.4300743 0.005131811 0.7635877345 0.846867733 3 125916718 125916719 2 + 0.639 0.605 -0.147
ENSG00000171084 E009 4.3595899 0.003996855 0.4056533841 0.549315707 3 125916720 125916817 98 + 0.781 0.680 -0.413
ENSG00000171084 E010 1.1781154 0.149535776 0.6998238567 0.799447236 3 125918693 125918863 171 + 0.264 0.354 0.586
ENSG00000171084 E011 5.7723145 0.004124032 0.5352804964 0.667157575 3 125918864 125918926 63 + 0.863 0.799 -0.250
ENSG00000171084 E012 0.1451727 0.043671361 0.2904054163   3 125919587 125919695 109 + 0.152 0.000 -11.678
ENSG00000171084 E013 8.7510648 0.002146932 0.6550686316 0.765039110 3 125920825 125920905 81 + 0.992 0.958 -0.126
ENSG00000171084 E014 0.3299976 0.027442404 0.3918136687   3 125922464 125922565 102 + 0.000 0.177 10.463
ENSG00000171084 E015 0.8803856 0.019490669 0.0206339251 0.052815522 3 125923664 125923796 133 + 0.491 0.098 -3.056
ENSG00000171084 E016 4.2727068 0.004012401 0.5571198036 0.685601909 3 125923879 125924140 262 + 0.749 0.680 -0.286
ENSG00000171084 E017 2.0230502 0.028649209 0.4114391321 0.555000315 3 125924412 125924737 326 + 0.354 0.514 0.850
ENSG00000171084 E018 15.1775219 0.039568312 0.4658861187 0.605483373 3 125924966 125925115 150 + 1.229 1.155 -0.261
ENSG00000171084 E019 91.7112262 0.006451638 0.0008182953 0.003325117 3 125928495 125930056 1562 + 1.864 1.979 0.386