ENSG00000171055

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000305852 ENSG00000171055 HEK293_OSMI2_2hA HEK293_TMG_2hB FEZ2 protein_coding protein_coding 13.96124 9.617136 20.67603 1.444494 0.3925468 1.103478 0.1342467 0.4582331 0.07629426 0.4582331 0.07629426 -2.4398904 0.01287083 0.0560000 0.003633333 -0.05236667 9.270818e-01 5.744278e-33 FALSE TRUE
ENST00000357996 ENSG00000171055 HEK293_OSMI2_2hA HEK293_TMG_2hB FEZ2 protein_coding protein_coding 13.96124 9.617136 20.67603 1.444494 0.3925468 1.103478 0.7585774 0.0000000 4.10543010 0.0000000 0.21023127 8.6848994 0.03653333 0.0000000 0.198366667 0.19836667 5.744278e-33 5.744278e-33 FALSE TRUE
ENST00000379245 ENSG00000171055 HEK293_OSMI2_2hA HEK293_TMG_2hB FEZ2 protein_coding protein_coding 13.96124 9.617136 20.67603 1.444494 0.3925468 1.103478 0.9662170 0.7890610 0.99472807 0.1419831 0.31096957 0.3304275 0.06639583 0.0848000 0.048633333 -0.03616667 4.891315e-01 5.744278e-33 FALSE TRUE
ENST00000405912 ENSG00000171055 HEK293_OSMI2_2hA HEK293_TMG_2hB FEZ2 protein_coding protein_coding 13.96124 9.617136 20.67603 1.444494 0.3925468 1.103478 9.7965320 7.0317063 13.39380090 1.2268665 0.74124700 0.9286452 0.72046250 0.7266333 0.647266667 -0.07936667 2.960548e-01 5.744278e-33 FALSE TRUE
ENST00000441005 ENSG00000171055 HEK293_OSMI2_2hA HEK293_TMG_2hB FEZ2 protein_coding protein_coding 13.96124 9.617136 20.67603 1.444494 0.3925468 1.103478 0.2648611 0.6513628 0.26262580 0.3340814 0.14941148 -1.2785197 0.02594167 0.0641000 0.012933333 -0.05116667 6.662343e-01 5.744278e-33 FALSE TRUE
ENST00000464964 ENSG00000171055 HEK293_OSMI2_2hA HEK293_TMG_2hB FEZ2 protein_coding processed_transcript 13.96124 9.617136 20.67603 1.444494 0.3925468 1.103478 0.9422522 0.0000000 0.00000000 0.0000000 0.00000000 0.0000000 0.05100000 0.0000000 0.000000000 0.00000000   5.744278e-33 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171055 E001 0.1472490 0.0449953798 7.663258e-01   2 36531805 36532021 217 - 0.100 0.000 -9.299
ENSG00000171055 E002 0.7437457 0.0156189795 3.620550e-01 5.064551e-01 2 36551427 36551491 65 - 0.309 0.149 -1.347
ENSG00000171055 E003 0.7665478 0.0254707950 3.719858e-01 5.164583e-01 2 36552056 36552114 59 - 0.309 0.149 -1.344
ENSG00000171055 E004 0.9096442 0.2272529398 3.805374e-01 5.248145e-01 2 36552115 36552168 54 - 0.360 0.149 -1.657
ENSG00000171055 E005 2.4972544 0.0072844435 5.103517e-01 6.455884e-01 2 36552169 36552257 89 - 0.586 0.483 -0.483
ENSG00000171055 E006 2.7772797 0.0062257507 3.807959e-01 5.250869e-01 2 36552258 36552262 5 - 0.523 0.669 0.652
ENSG00000171055 E007 3.9532181 0.0042000774 1.018549e-01 1.933246e-01 2 36552263 36552264 2 - 0.586 0.827 1.001
ENSG00000171055 E008 27.6802031 0.0007016230 2.012339e-03 7.264462e-03 2 36552265 36552303 39 - 1.358 1.567 0.721
ENSG00000171055 E009 199.0312100 0.0016321399 2.747214e-10 4.497894e-09 2 36552304 36552710 407 - 2.212 2.403 0.638
ENSG00000171055 E010 87.2961792 0.0082651853 2.952754e-01 4.364123e-01 2 36552711 36552782 72 - 1.913 1.991 0.262
ENSG00000171055 E011 118.9729513 0.0002825197 6.080553e-07 5.291179e-06 2 36552783 36552946 164 - 2.003 2.169 0.556
ENSG00000171055 E012 147.5693917 0.0055713519 3.459001e-01 4.900366e-01 2 36552947 36553179 233 - 2.154 2.193 0.129
ENSG00000171055 E013 1.3212128 0.0167570068 9.295501e-01 9.596408e-01 2 36554170 36554262 93 - 0.361 0.348 -0.080
ENSG00000171055 E014 0.1472490 0.0449953798 7.663258e-01   2 36555289 36555682 394 - 0.100 0.000 -11.104
ENSG00000171055 E015 43.8726246 0.0005013612 8.183800e-01 8.852096e-01 2 36555683 36555687 5 - 1.644 1.666 0.073
ENSG00000171055 E016 84.0469981 0.0024417350 7.456373e-01 8.336249e-01 2 36555688 36555748 61 - 1.920 1.937 0.057
ENSG00000171055 E017 1.8704801 0.0176107401 8.698078e-01 9.202727e-01 2 36555749 36555976 228 - 0.449 0.483 0.168
ENSG00000171055 E018 2.0605904 0.0076197218 6.262671e-01 7.422375e-01 2 36555977 36556060 84 - 0.450 0.538 0.432
ENSG00000171055 E019 7.0357084 0.0273798215 1.899924e-01 3.137563e-01 2 36556061 36558437 2377 - 0.968 0.774 -0.748
ENSG00000171055 E020 75.9863498 0.0035161686 9.295650e-01 9.596492e-01 2 36558438 36558513 76 - 1.885 1.881 -0.013
ENSG00000171055 E021 1.8853556 0.0445067716 8.665087e-01 9.180630e-01 2 36558514 36559255 742 - 0.450 0.482 0.164
ENSG00000171055 E022 6.7974084 0.0456723918 3.444580e-01 4.885450e-01 2 36560785 36560865 81 - 0.827 0.961 0.511
ENSG00000171055 E023 0.7405115 0.3319567674 1.374697e-01 2.445625e-01 2 36561338 36561498 161 - 0.361 0.000 -12.858
ENSG00000171055 E024 163.1183434 0.0003101515 3.809119e-02 8.752181e-02 2 36578597 36578865 269 - 2.236 2.189 -0.159
ENSG00000171055 E025 0.1451727 0.0441566326 7.667475e-01   2 36578958 36579090 133 - 0.100 0.000 -11.105
ENSG00000171055 E026 125.1375395 0.0002428602 1.286393e-05 8.331451e-05 2 36581290 36581431 142 - 2.153 2.026 -0.425
ENSG00000171055 E027 0.1515154 0.0445064644 7.664307e-01   2 36581505 36581590 86 - 0.100 0.000 -11.105
ENSG00000171055 E028 102.8133838 0.0003878839 8.512602e-11 1.520829e-09 2 36583353 36583469 117 - 2.103 1.881 -0.745
ENSG00000171055 E029 0.0000000       2 36584030 36584058 29 -      
ENSG00000171055 E030 0.1515154 0.0445064644 7.664307e-01   2 36589641 36590902 1262 - 0.100 0.000 -11.105
ENSG00000171055 E031 78.5013381 0.0005035956 1.880029e-08 2.203451e-07 2 36590903 36591011 109 - 1.987 1.764 -0.749
ENSG00000171055 E032 0.1472490 0.0449953798 7.663258e-01   2 36591012 36591553 542 - 0.100 0.000 -11.104
ENSG00000171055 E033 0.0000000       2 36594414 36594566 153 -      
ENSG00000171055 E034 38.8163150 0.0165828114 2.539139e-02 6.268337e-02 2 36597877 36598191 315 - 1.673 1.480 -0.660
ENSG00000171055 E035 0.0000000       2 36646015 36646087 73 -