ENSG00000171045

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000518928 ENSG00000171045 HEK293_OSMI2_2hA HEK293_TMG_2hB TSNARE1 protein_coding processed_transcript 6.157671 9.049087 4.020853 0.3499815 0.06634464 -1.16828 1.0055461 2.0769571 0.2100499 0.2018766 0.05817370 -3.2454982 0.14594583 0.22986667 0.0519000 -0.17796667 1.719066e-05 1.719066e-05 FALSE TRUE
ENST00000519651 ENSG00000171045 HEK293_OSMI2_2hA HEK293_TMG_2hB TSNARE1 protein_coding protein_coding 6.157671 9.049087 4.020853 0.3499815 0.06634464 -1.16828 2.4422858 3.4237847 1.6135018 0.1043477 0.08137087 -1.0806906 0.39601667 0.37906667 0.4020667 0.02300000 8.496951e-01 1.719066e-05 FALSE TRUE
MSTRG.32164.14 ENSG00000171045 HEK293_OSMI2_2hA HEK293_TMG_2hB TSNARE1 protein_coding   6.157671 9.049087 4.020853 0.3499815 0.06634464 -1.16828 0.6104764 0.0000000 0.6042691 0.0000000 0.36700114 5.9407989 0.10837917 0.00000000 0.1497000 0.14970000 1.201995e-01 1.719066e-05 FALSE TRUE
MSTRG.32164.5 ENSG00000171045 HEK293_OSMI2_2hA HEK293_TMG_2hB TSNARE1 protein_coding   6.157671 9.049087 4.020853 0.3499815 0.06634464 -1.16828 0.2759727 0.5202320 0.4484077 0.2662137 0.24066017 -0.2099923 0.05192917 0.05986667 0.1097667 0.04990000 9.089578e-01 1.719066e-05 FALSE TRUE
MSTRG.32164.6 ENSG00000171045 HEK293_OSMI2_2hA HEK293_TMG_2hB TSNARE1 protein_coding   6.157671 9.049087 4.020853 0.3499815 0.06634464 -1.16828 0.2623180 1.1184435 0.0000000 0.5876974 0.00000000 -6.8181903 0.04002917 0.12786667 0.0000000 -0.12786667 2.486910e-01 1.719066e-05 FALSE TRUE
MSTRG.32164.7 ENSG00000171045 HEK293_OSMI2_2hA HEK293_TMG_2hB TSNARE1 protein_coding   6.157671 9.049087 4.020853 0.3499815 0.06634464 -1.16828 0.4223432 0.6593417 0.4788264 0.6593417 0.41120552 -0.4534208 0.06811250 0.06786667 0.1218333 0.05396667 6.756731e-01 1.719066e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171045 E001 0.0000000       8 142212080 142212080 1 -      
ENSG00000171045 E002 0.0000000       8 142212081 142212166 86 -      
ENSG00000171045 E003 0.4815130 0.0219519862 9.001285e-01 9.402650e-01 8 142212167 142212313 147 - 0.174 0.155 -0.202
ENSG00000171045 E004 0.5212538 0.0201361240 9.007991e-01 9.407383e-01 8 142229473 142229579 107 - 0.174 0.155 -0.200
ENSG00000171045 E005 100.0758569 0.0003892768 3.694425e-01 5.138599e-01 8 142270475 142271270 796 - 1.921 1.960 0.131
ENSG00000171045 E006 28.5508601 0.0056621214 3.258394e-01 4.692780e-01 8 142271271 142271340 70 - 1.356 1.440 0.292
ENSG00000171045 E007 17.1632991 0.0236303824 1.187440e-01 2.181464e-01 8 142271341 142271343 3 - 1.056 1.253 0.705
ENSG00000171045 E008 26.6854626 0.0116500339 3.389821e-01 4.828798e-01 8 142271344 142271413 70 - 1.317 1.411 0.327
ENSG00000171045 E009 38.4466860 0.0027222148 3.593848e-01 5.037158e-01 8 142271414 142271566 153 - 1.493 1.559 0.227
ENSG00000171045 E010 16.4749416 0.0011542948 5.204422e-01 6.543982e-01 8 142271567 142271597 31 - 1.141 1.205 0.229
ENSG00000171045 E011 23.6727563 0.0008247064 1.229144e-02 3.423319e-02 8 142271598 142271691 94 - 1.171 1.384 0.748
ENSG00000171045 E012 3.9534957 0.0043490715 1.234335e-03 4.757315e-03 8 142273549 142273587 39 - 0.924 0.467 -1.936
ENSG00000171045 E013 17.5244413 0.0010938179 1.140408e-01 2.114095e-01 8 142274781 142274863 83 - 1.091 1.244 0.544
ENSG00000171045 E014 5.2797018 0.0072454366 5.315236e-02 1.147606e-01 8 142278761 142278841 81 - 0.924 0.667 -1.020
ENSG00000171045 E015 20.9162285 0.0019352733 2.853443e-01 4.256573e-01 8 142279860 142280188 329 - 1.337 1.255 -0.286
ENSG00000171045 E016 10.4664499 0.0021151725 7.664168e-01 8.489201e-01 8 142280189 142280324 136 - 0.972 1.010 0.140
ENSG00000171045 E017 15.9359234 0.0839129879 8.369783e-01 8.980458e-01 8 142284413 142284485 73 - 1.214 1.158 -0.201
ENSG00000171045 E018 24.2463536 0.0060337314 8.597690e-09 1.072854e-07 8 142300116 142300485 370 - 0.840 1.453 2.209
ENSG00000171045 E019 48.8945005 0.0202285390 2.137231e-01 3.429147e-01 8 142300486 142300644 159 - 1.563 1.670 0.362
ENSG00000171045 E020 9.3635356 0.0022553923 3.724703e-01 5.169327e-01 8 142300645 142300647 3 - 0.870 0.982 0.423
ENSG00000171045 E021 25.0883842 0.0009626592 5.616451e-01 6.894088e-01 8 142314384 142314440 57 - 1.327 1.376 0.170
ENSG00000171045 E022 26.6559064 0.0007464057 6.073765e-01 7.273678e-01 8 142315003 142315089 87 - 1.356 1.399 0.148
ENSG00000171045 E023 11.9137321 0.0019603618 9.889008e-01 9.970797e-01 8 142315090 142315092 3 - 1.055 1.062 0.023
ENSG00000171045 E024 37.0627241 0.0006567393 3.223505e-01 4.656622e-01 8 142318544 142318634 91 - 1.562 1.507 -0.189
ENSG00000171045 E025 0.0000000       8 142326053 142326225 173 -      
ENSG00000171045 E026 38.1634051 0.0006633179 2.393582e-03 8.440958e-03 8 142330901 142330970 70 - 1.657 1.486 -0.583
ENSG00000171045 E027 36.7119889 0.0006280332 8.048398e-05 4.302206e-04 8 142331754 142331831 78 - 1.675 1.451 -0.766
ENSG00000171045 E028 47.6457171 0.0005486145 4.978995e-04 2.152078e-03 8 142343966 142344259 294 - 1.750 1.574 -0.597
ENSG00000171045 E029 29.4674247 0.0040784498 7.047610e-01 8.032445e-01 8 142344260 142344352 93 - 1.441 1.419 -0.079
ENSG00000171045 E030 30.2734623 0.0008465670 9.404229e-01 9.665972e-01 8 142344353 142344472 120 - 1.441 1.441 0.000
ENSG00000171045 E031 28.1175495 0.0042473872 9.527569e-01 9.744003e-01 8 142345743 142345892 150 - 1.409 1.419 0.035
ENSG00000171045 E032 30.0125131 0.0009365701 5.853870e-01 7.090908e-01 8 142354637 142354763 127 - 1.457 1.424 -0.111
ENSG00000171045 E033 1.3994745 0.0102356258 3.686210e-01 5.130299e-01 8 142365911 142366017 107 - 0.473 0.316 -0.880
ENSG00000171045 E034 0.3289534 0.0288889642 5.390544e-01   8 142402790 142403103 314 - 0.174 0.084 -1.199
ENSG00000171045 E035 12.5480411 0.0251357882 5.919575e-01 7.145925e-01 8 142403104 142403240 137 - 1.108 1.053 -0.202