ENSG00000171044

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000297303 ENSG00000171044 HEK293_OSMI2_2hA HEK293_TMG_2hB XKR6 protein_coding protein_coding 1.160315 1.183973 1.17089 0.2853672 0.03060789 -0.01589472 0.08144442 0.06362937 0.11760805 0.05189689 0.03520430 0.79336610 0.07143333 0.06613333 0.09900000 0.032866667 0.77758920 0.04565289 FALSE TRUE
ENST00000382461 ENSG00000171044 HEK293_OSMI2_2hA HEK293_TMG_2hB XKR6 protein_coding protein_coding 1.160315 1.183973 1.17089 0.2853672 0.03060789 -0.01589472 0.14509125 0.15295517 0.14669992 0.07647760 0.07364549 -0.05647068 0.12572083 0.13720000 0.12663333 -0.010566667 1.00000000 0.04565289 FALSE TRUE
ENST00000416569 ENSG00000171044 HEK293_OSMI2_2hA HEK293_TMG_2hB XKR6 protein_coding protein_coding 1.160315 1.183973 1.17089 0.2853672 0.03060789 -0.01589472 0.11093449 0.06154335 0.08495186 0.06154335 0.08495186 0.40837859 0.09845833 0.06233333 0.07100000 0.008666667 1.00000000 0.04565289 FALSE TRUE
ENST00000529336 ENSG00000171044 HEK293_OSMI2_2hA HEK293_TMG_2hB XKR6 protein_coding nonsense_mediated_decay 1.160315 1.183973 1.17089 0.2853672 0.03060789 -0.01589472 0.45536827 0.46368627 0.49968611 0.23176925 0.09613614 0.10567719 0.39555417 0.34523333 0.42870000 0.083466667 0.86422604 0.04565289 TRUE TRUE
MSTRG.31125.1 ENSG00000171044 HEK293_OSMI2_2hA HEK293_TMG_2hB XKR6 protein_coding   1.160315 1.183973 1.17089 0.2853672 0.03060789 -0.01589472 0.06113951 0.00000000 0.07918465 0.00000000 0.07918465 3.15679544 0.05059167 0.00000000 0.06563333 0.065633333 0.79874404 0.04565289 FALSE TRUE
MSTRG.31125.5 ENSG00000171044 HEK293_OSMI2_2hA HEK293_TMG_2hB XKR6 protein_coding   1.160315 1.183973 1.17089 0.2853672 0.03060789 -0.01589472 0.13137856 0.09503212 0.15705519 0.05505839 0.08979069 0.66949415 0.11150000 0.07483333 0.13766667 0.062833333 0.88587012 0.04565289 TRUE TRUE
MSTRG.31125.6 ENSG00000171044 HEK293_OSMI2_2hA HEK293_TMG_2hB XKR6 protein_coding   1.160315 1.183973 1.17089 0.2853672 0.03060789 -0.01589472 0.17495884 0.34712630 0.08570455 0.04539330 0.04716487 -1.89977499 0.14673750 0.31420000 0.07143333 -0.242766667 0.04565289 0.04565289 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171044 E001 0.000000       8 10889719 10889768 50 -      
ENSG00000171044 E002 13.607335 0.002577309 0.998106562 1.000000000 8 10896045 10898614 2570 - 1.161 1.162 0.003
ENSG00000171044 E003 7.335313 0.002706566 0.037271032 0.085984621 8 10898615 10898916 302 - 1.032 0.802 -0.872
ENSG00000171044 E004 4.793121 0.003690756 0.091222205 0.177040138 8 10924634 10924830 197 - 0.869 0.649 -0.890
ENSG00000171044 E005 0.000000       8 11002388 11002481 94 -      
ENSG00000171044 E006 5.257132 0.003502452 0.019756577 0.050971323 8 11111645 11111771 127 - 0.942 0.649 -1.167
ENSG00000171044 E007 2.676216 0.008461435 0.375144083 0.519551148 8 11111772 11111808 37 - 0.641 0.505 -0.618
ENSG00000171044 E008 9.526510 0.002074337 0.182539847 0.304399301 8 11111809 11111892 84 - 0.942 1.079 0.503
ENSG00000171044 E009 8.179437 0.003246522 0.460806973 0.600786602 8 11113872 11114020 149 - 0.907 0.991 0.314
ENSG00000171044 E010 9.475111 0.001938995 0.002089947 0.007502165 8 11114021 11114092 72 - 0.806 1.132 1.220
ENSG00000171044 E011 1.954243 0.027306510 0.139316584 0.247114919 8 11194436 11195090 655 - 0.606 0.352 -1.277
ENSG00000171044 E012 2.687174 0.041812917 0.619138807 0.736627852 8 11195091 11195221 131 - 0.526 0.614 0.401
ENSG00000171044 E013 29.071586 0.028556416 0.718483688 0.813565019 8 11200576 11201833 1258 - 1.442 1.486 0.151