ENSG00000171004

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370836 ENSG00000171004 HEK293_OSMI2_2hA HEK293_TMG_2hB HS6ST2 protein_coding protein_coding 17.59124 8.240372 29.55362 0.2605596 0.4947356 1.841292 8.9838637 2.5367948 17.0555243 0.6163956 1.1419435 2.744330 0.4486375 0.31100000 0.57873333 0.26773333 7.391975e-02 2.200078e-07 FALSE TRUE
ENST00000406696 ENSG00000171004 HEK293_OSMI2_2hA HEK293_TMG_2hB HS6ST2 protein_coding protein_coding 17.59124 8.240372 29.55362 0.2605596 0.4947356 1.841292 6.9998785 3.7032190 11.2752569 0.5651608 1.9522440 1.603697 0.3952375 0.44600000 0.37950000 -0.06650000 7.439184e-01 2.200078e-07 FALSE TRUE
MSTRG.34892.10 ENSG00000171004 HEK293_OSMI2_2hA HEK293_TMG_2hB HS6ST2 protein_coding   17.59124 8.240372 29.55362 0.2605596 0.4947356 1.841292 0.1548763 0.4087222 0.0000000 0.2152836 0.0000000 -5.387922 0.0225625 0.05013333 0.00000000 -0.05013333 1.360077e-05 2.200078e-07 FALSE TRUE
MSTRG.34892.11 ENSG00000171004 HEK293_OSMI2_2hA HEK293_TMG_2hB HS6ST2 protein_coding   17.59124 8.240372 29.55362 0.2605596 0.4947356 1.841292 0.7767541 1.2919576 0.3990647 0.2662392 0.1142921 -1.670282 0.0910750 0.15686667 0.01363333 -0.14323333 2.200078e-07 2.200078e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000171004 E001 0.2998086 0.0289192951 3.178481e-01   X 132626015 132626015 1 - 0.059 0.237 2.324
ENSG00000171004 E002 0.5985731 0.0218772122 8.164626e-01 8.838752e-01 X 132626016 132626027 12 - 0.157 0.238 0.740
ENSG00000171004 E003 964.6162824 0.0107466935 5.933320e-04 2.509320e-03 X 132626028 132627969 1942 - 2.834 3.044 0.700
ENSG00000171004 E004 440.6153101 0.0005398007 1.733840e-22 1.464426e-20 X 132627970 132628743 774 - 2.564 2.446 -0.391
ENSG00000171004 E005 148.6286706 0.0026295661 1.407459e-13 3.915401e-12 X 132628744 132628904 161 - 2.113 1.864 -0.835
ENSG00000171004 E006 59.2838972 0.0024777943 8.370884e-08 8.629477e-07 X 132628905 132628911 7 - 1.723 1.457 -0.907
ENSG00000171004 E007 136.4024868 0.0032706927 4.963902e-13 1.278929e-11 X 132628912 132629093 182 - 2.079 1.813 -0.892
ENSG00000171004 E008 2.2112786 0.1558622486 5.730203e-01 6.990237e-01 X 132669113 132669199 87 - 0.460 0.386 -0.395
ENSG00000171004 E009 3.8636124 0.0090395118 1.613102e-02 4.302431e-02 X 132708462 132708494 33 - 0.666 0.238 -2.316
ENSG00000171004 E010 0.4031496 0.0269732047 2.051841e-02 5.258308e-02 X 132709923 132709937 15 - 0.000 0.391 13.074
ENSG00000171004 E011 13.5498074 0.0557386543 1.290157e-16 5.478959e-15 X 132709938 132710140 203 - 0.390 1.700 5.078
ENSG00000171004 E012 0.6265839 0.0269496037 7.954653e-04 3.243582e-03 X 132735084 132735393 310 - 0.000 0.591 14.049
ENSG00000171004 E013 10.5477016 0.2071490382 2.240498e-08 2.587670e-07 X 132758256 132758332 77 - 0.199 1.622 6.138
ENSG00000171004 E014 117.8128270 0.0003714930 7.290134e-01 8.213220e-01 X 132956808 132956915 108 - 1.948 2.065 0.393
ENSG00000171004 E015 108.7764693 0.0032880934 5.638705e-02 1.204042e-01 X 132956916 132957016 101 - 1.895 2.086 0.642
ENSG00000171004 E016 195.1089918 0.0055446483 2.160491e-02 5.485913e-02 X 132957017 132957326 310 - 2.143 2.344 0.671
ENSG00000171004 E017 0.1451727 0.0433061971 1.000000e+00   X 132957446 132957515 70 - 0.059 0.000 -9.512
ENSG00000171004 E018 0.2903454 0.3560352681 1.000000e+00   X 132957682 132957784 103 - 0.110 0.000 -9.681
ENSG00000171004 E019 1.9865080 0.0077024579 1.374508e-01 2.445313e-01 X 132957874 132957920 47 - 0.335 0.667 1.648
ENSG00000171004 E020 3.9905947 0.1954231609 3.095700e-01 4.518894e-01 X 132957921 132958174 254 - 0.539 0.841 1.274
ENSG00000171004 E021 103.6350023 0.0067550552 5.053028e-01 6.411065e-01 X 132958175 132958868 694 - 1.904 1.967 0.213
ENSG00000171004 E022 0.0000000       X 132958869 132959638 770 -      
ENSG00000171004 E023 0.1451727 0.0433061971 1.000000e+00   X 132961246 132961395 150 - 0.059 0.000 -9.512