ENSG00000170946

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000465995 ENSG00000170946 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJC24 protein_coding protein_coding 10.25184 3.591686 14.37192 0.2816075 0.7435545 1.997512 5.5348120 2.08396260 6.7682873 0.207807635 0.23065660 1.694685 0.56119167 0.58016667 0.47283333 -0.10733333 0.206826564 0.008707421 FALSE  
ENST00000524747 ENSG00000170946 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJC24 protein_coding processed_transcript 10.25184 3.591686 14.37192 0.2816075 0.7435545 1.997512 0.2749700 0.00000000 0.7632538 0.000000000 0.27662021 6.272870 0.03108750 0.00000000 0.05540000 0.05540000 0.008707421 0.008707421    
ENST00000525511 ENSG00000170946 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJC24 protein_coding nonsense_mediated_decay 10.25184 3.591686 14.37192 0.2816075 0.7435545 1.997512 0.5673061 0.06257147 1.0492300 0.062571474 0.63518423 3.867469 0.03924583 0.01600000 0.06900000 0.05300000 0.696615080 0.008707421    
ENST00000529086 ENSG00000170946 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJC24 protein_coding retained_intron 10.25184 3.591686 14.37192 0.2816075 0.7435545 1.997512 0.5174656 0.35877308 0.9348029 0.002376924 0.01628871 1.357280 0.05793333 0.10130000 0.06556667 -0.03573333 0.314490443 0.008707421    
MSTRG.5348.9 ENSG00000170946 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJC24 protein_coding   10.25184 3.591686 14.37192 0.2816075 0.7435545 1.997512 1.0007707 0.23025476 1.3403040 0.034125791 0.17567790 2.490647 0.09016250 0.06373333 0.09510000 0.03136667 0.565920367 0.008707421 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170946 E001 0.1515154 0.0428276312 1.0000000000   11 31369810 31369817 8 + 0.067 0.000 -8.675
ENSG00000170946 E002 0.1515154 0.0428276312 1.0000000000   11 31369818 31369818 1 + 0.067 0.000 -10.271
ENSG00000170946 E003 0.2966881 0.0270693380 1.0000000000   11 31369819 31369821 3 + 0.125 0.000 -11.323
ENSG00000170946 E004 0.4418608 0.0263720125 0.5389831568 0.6703110400 11 31369822 31369839 18 + 0.176 0.000 -11.870
ENSG00000170946 E005 0.5933762 0.0228207083 0.3622333448 0.5066223254 11 31369840 31369841 2 + 0.222 0.000 -12.268
ENSG00000170946 E006 0.5933762 0.0228207083 0.3622333448 0.5066223254 11 31369842 31369842 1 + 0.222 0.000 -12.268
ENSG00000170946 E007 0.5933762 0.0228207083 0.3622333448 0.5066223254 11 31369843 31369843 1 + 0.222 0.000 -12.268
ENSG00000170946 E008 0.5933762 0.0228207083 0.3622333448 0.5066223254 11 31369844 31369847 4 + 0.222 0.000 -12.268
ENSG00000170946 E009 1.0415798 0.1457401558 0.1754086350 0.2951981858 11 31369848 31369853 6 + 0.337 0.000 -12.551
ENSG00000170946 E010 3.6289275 0.0069517156 0.0820962233 0.1628368983 11 31369854 31369856 3 + 0.670 0.356 -1.537
ENSG00000170946 E011 6.8031951 0.0024116524 0.0223258888 0.0563529765 11 31369857 31369859 3 + 0.895 0.548 -1.435
ENSG00000170946 E012 11.8002502 0.0014707777 0.0197967229 0.0510561247 11 31369860 31369863 4 + 1.098 0.826 -1.016
ENSG00000170946 E013 43.6782244 0.0006715757 0.0103699871 0.0296731272 11 31369864 31369912 49 + 1.616 1.470 -0.498
ENSG00000170946 E014 68.3261129 0.0005036944 0.2062488919 0.3340192157 11 31370716 31370806 91 + 1.785 1.744 -0.139
ENSG00000170946 E015 63.7677847 0.0012251254 0.1935736243 0.3182738187 11 31370807 31370859 53 + 1.756 1.708 -0.161
ENSG00000170946 E016 0.9525186 0.0159970244 0.5160743000 0.6506520706 11 31374103 31374205 103 + 0.222 0.356 0.923
ENSG00000170946 E017 0.4470576 0.0213411782 0.6266412551 0.7425420369 11 31384594 31385100 507 + 0.125 0.213 0.921
ENSG00000170946 E018 1.5136295 0.1790492253 0.4401246671 0.5818217823 11 31396283 31396394 112 + 0.399 0.214 -1.244
ENSG00000170946 E019 0.9599941 0.0500374245 0.7807786078 0.8591585053 11 31407456 31407543 88 + 0.264 0.214 -0.394
ENSG00000170946 E020 10.1265560 0.0463762086 0.9284915488 0.9590113208 11 31408110 31408330 221 + 0.978 0.997 0.070
ENSG00000170946 E021 84.2206671 0.0005552729 0.1233322466 0.2247167504 11 31414811 31414949 139 + 1.841 1.928 0.291
ENSG00000170946 E022 34.4712898 0.0005811660 0.0001876650 0.0009109036 11 31414950 31417011 2062 + 1.408 1.663 0.873
ENSG00000170946 E023 1.7746146 0.0128007584 0.7936957593 0.8681314730 11 31417012 31417242 231 + 0.399 0.462 0.334
ENSG00000170946 E024 2.2206281 0.0071452002 0.8696330137 0.9201610538 11 31417243 31417338 96 + 0.478 0.462 -0.079
ENSG00000170946 E025 1.9209213 0.0072569206 0.0228404790 0.0574109093 11 31421972 31422064 93 + 0.501 0.000 -13.778
ENSG00000170946 E026 2.0767031 0.0068837597 0.0173271797 0.0456649910 11 31422065 31422132 68 + 0.524 0.000 -13.862
ENSG00000170946 E027 26.5088150 0.0007879217 0.0469517927 0.1037400139 11 31426287 31426289 3 + 1.402 1.258 -0.502
ENSG00000170946 E028 40.5521351 0.0006762486 0.1735454106 0.2927860218 11 31426290 31426355 66 + 1.565 1.497 -0.233
ENSG00000170946 E029 5.8796294 0.0027885276 0.6196171438 0.7369655455 11 31426356 31426480 125 + 0.791 0.735 -0.224
ENSG00000170946 E030 15.3177535 0.0012088226 0.0105764748 0.0301536730 11 31426481 31427978 1498 + 1.201 0.935 -0.968
ENSG00000170946 E031 12.9103886 0.0554128852 0.0128429942 0.0355472447 11 31429483 31429606 124 + 1.148 0.739 -1.542
ENSG00000170946 E032 11.6838942 0.0217473981 0.0475105787 0.1047522998 11 31429607 31429880 274 + 1.092 0.826 -0.995
ENSG00000170946 E033 339.4685294 0.0049029678 0.0005597924 0.0023840792 11 31430271 31432835 2565 + 2.436 2.545 0.363