ENSG00000170921

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000424789 ENSG00000170921 HEK293_OSMI2_2hA HEK293_TMG_2hB TANC2 protein_coding protein_coding 2.645683 2.758826 2.432528 0.1739482 0.07414518 -0.1808996 1.1524081 2.0721583 0.2959898 0.1901663 0.14800271 -2.766524 0.40647083 0.7488000 0.11946667 -0.62933333 5.496321e-03 3.279738e-12 FALSE TRUE
MSTRG.14871.2 ENSG00000170921 HEK293_OSMI2_2hA HEK293_TMG_2hB TANC2 protein_coding   2.645683 2.758826 2.432528 0.1739482 0.07414518 -0.1808996 0.1481247 0.0000000 0.2038254 0.0000000 0.20382536 4.418361 0.06200833 0.0000000 0.08733333 0.08733333 8.110229e-01 3.279738e-12 FALSE TRUE
MSTRG.14871.3 ENSG00000170921 HEK293_OSMI2_2hA HEK293_TMG_2hB TANC2 protein_coding   2.645683 2.758826 2.432528 0.1739482 0.07414518 -0.1808996 1.0402834 0.4445019 1.6801683 0.1049251 0.02426614 1.894809 0.41919583 0.1587667 0.69213333 0.53336667 3.279738e-12 3.279738e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170921 E001 0.5933762 0.0226419008 3.389662e-02 7.954432e-02 17 62966235 62966528 294 + 0.326 0.000 -11.897
ENSG00000170921 E002 0.5891098 0.0183841796 3.337456e-02 7.852932e-02 17 62966529 62966539 11 + 0.326 0.000 -14.137
ENSG00000170921 E003 1.0298247 0.0118779880 4.310513e-02 9.674601e-02 17 62966540 62966616 77 + 0.427 0.140 -2.143
ENSG00000170921 E004 1.4621206 0.3994835668 2.260037e-01 3.576052e-01 17 62966617 62966649 33 + 0.507 0.238 -1.599
ENSG00000170921 E005 3.3163317 0.0249043314 6.112978e-04 2.574495e-03 17 62966650 62966749 100 + 0.799 0.330 -2.221
ENSG00000170921 E006 2.1476770 0.0071878516 4.299677e-03 1.398340e-02 17 63009537 63009555 19 + 0.638 0.245 -2.142
ENSG00000170921 E007 2.3044910 0.0085518926 2.294735e-04 1.089824e-03 17 63009556 63009559 4 + 0.691 0.140 -3.364
ENSG00000170921 E008 3.2415824 0.0721378992 7.572596e-04 3.105409e-03 17 63009560 63009626 67 + 0.801 0.246 -2.801
ENSG00000170921 E009 2.6429076 0.0384277449 9.195104e-03 2.677300e-02 17 63073943 63073944 2 + 0.691 0.330 -1.780
ENSG00000170921 E010 3.2373135 0.0839091577 6.285559e-02 1.314690e-01 17 63073945 63073958 14 + 0.716 0.466 -1.128
ENSG00000170921 E011 3.5382680 0.1146961104 5.561832e-02 1.190433e-01 17 63073959 63074014 56 + 0.761 0.467 -1.305
ENSG00000170921 E012 5.9014087 0.0028714688 5.327555e-02 1.149794e-01 17 63099175 63099246 72 + 0.886 0.773 -0.441
ENSG00000170921 E013 8.6931623 0.0019051835 1.043519e-03 4.109415e-03 17 63099247 63099357 111 + 1.075 0.850 -0.842
ENSG00000170921 E014 0.0000000       17 63148228 63151269 3042 +      
ENSG00000170921 E015 0.5085815 0.1676374146 6.405897e-01 7.538079e-01 17 63151270 63151380 111 + 0.107 0.246 1.450
ENSG00000170921 E016 0.0000000       17 63151381 63155226 3846 +      
ENSG00000170921 E017 4.7847180 0.0109951744 5.961697e-03 1.850681e-02 17 63193991 63193993 3 + 0.870 0.606 -1.081
ENSG00000170921 E018 12.9068195 0.0013879790 4.809431e-08 5.207958e-07 17 63193994 63194139 146 + 1.282 0.894 -1.409
ENSG00000170921 E019 13.1077545 0.0013355722 7.326993e-09 9.254462e-08 17 63200771 63200957 187 + 1.294 0.872 -1.535
ENSG00000170921 E020 15.4084646 0.0012764974 9.336459e-07 7.797267e-06 17 63237814 63238077 264 + 1.324 1.036 -1.026
ENSG00000170921 E021 10.4387062 0.0016884454 9.802401e-05 5.127383e-04 17 63267748 63267873 126 + 1.158 0.894 -0.971
ENSG00000170921 E022 16.2639479 0.0011479968 1.732720e-09 2.456658e-08 17 63314388 63314669 282 + 1.373 0.988 -1.373
ENSG00000170921 E023 12.4574937 0.0019252683 3.497465e-05 2.044824e-04 17 63318957 63319090 134 + 1.228 0.971 -0.930
ENSG00000170921 E024 13.1965206 0.0039392569 3.195710e-05 1.888802e-04 17 63340101 63340332 232 + 1.249 0.989 -0.939
ENSG00000170921 E025 13.9859988 0.0014665958 1.541880e-06 1.228982e-05 17 63351250 63351416 167 + 1.288 0.988 -1.077
ENSG00000170921 E026 18.5890218 0.0028164640 5.484275e-06 3.868273e-05 17 63354783 63355054 272 + 1.383 1.155 -0.802
ENSG00000170921 E027 18.4032112 0.0012243499 3.681630e-06 2.702654e-05 17 63355055 63355390 336 + 1.373 1.143 -0.808
ENSG00000170921 E028 10.5960319 0.0042696773 3.661697e-02 8.474447e-02 17 63379718 63379826 109 + 1.095 1.021 -0.269
ENSG00000170921 E029 8.6332710 0.0469596777 1.018344e-01 1.932913e-01 17 63388635 63388691 57 + 1.020 0.936 -0.314
ENSG00000170921 E030 9.8648448 0.0021182171 6.827049e-02 1.405036e-01 17 63388692 63388757 66 + 1.054 1.005 -0.181
ENSG00000170921 E031 16.1535441 0.0782932430 1.133504e-01 2.104025e-01 17 63389308 63389544 237 + 1.262 1.184 -0.277
ENSG00000170921 E032 1.6724155 0.0764631382 9.770502e-01 9.896767e-01 17 63389545 63391757 2213 + 0.380 0.463 0.445
ENSG00000170921 E033 11.2150876 0.0110563522 1.723147e-01 2.912217e-01 17 63395743 63395928 186 + 1.085 1.080 -0.016
ENSG00000170921 E034 0.4428904 0.4372671308 3.159780e-01 4.587514e-01 17 63395929 63396976 1048 + 0.000 0.255 11.801
ENSG00000170921 E035 7.3977782 0.0023058213 7.639117e-01 8.471229e-01 17 63398821 63398914 94 + 0.870 0.971 0.380
ENSG00000170921 E036 0.5963950 0.4713457914 5.660650e-01 6.930788e-01 17 63398915 63399286 372 + 0.107 0.317 1.942
ENSG00000170921 E037 10.1948554 0.0181326427 1.658453e-01 2.827984e-01 17 63405122 63405255 134 + 1.054 1.037 -0.061
ENSG00000170921 E038 9.6646073 0.0017781486 4.223488e-03 1.376715e-02 17 63406154 63406277 124 + 1.095 0.934 -0.592
ENSG00000170921 E039 13.7384129 0.0012796720 6.983100e-05 3.792144e-04 17 63411511 63411686 176 + 1.256 1.036 -0.787
ENSG00000170921 E040 13.1525242 0.0013882407 7.114702e-04 2.939714e-03 17 63411998 63412130 133 + 1.221 1.051 -0.609
ENSG00000170921 E041 0.5483223 0.0200168894 5.933762e-01 7.157851e-01 17 63412680 63412709 30 + 0.107 0.246 1.446
ENSG00000170921 E042 0.0000000       17 63413171 63413542 372 +      
ENSG00000170921 E043 10.0010973 0.0018299409 1.270740e-03 4.879754e-03 17 63413543 63413634 92 + 1.114 0.915 -0.734
ENSG00000170921 E044 16.1556258 0.0313887504 1.891133e-02 4.913792e-02 17 63415528 63415674 147 + 1.282 1.151 -0.464
ENSG00000170921 E045 10.7393332 0.0413644835 7.709645e-03 2.304973e-02 17 63418307 63418407 101 + 1.158 0.936 -0.809
ENSG00000170921 E046 0.2944980 0.3945507648 2.818571e-01   17 63419996 63419998 3 + 0.192 0.000 -12.335
ENSG00000170921 E047 100.2487356 0.0009357062 9.413426e-09 1.167034e-07 17 63419999 63422025 2027 + 2.025 1.972 -0.178
ENSG00000170921 E048 261.2535124 0.0006371878 1.343455e-02 3.692669e-02 17 63422026 63425611 3586 + 2.303 2.510 0.690
ENSG00000170921 E049 333.1495522 0.0200796303 1.649728e-18 8.841187e-17 17 63425612 63427703 2092 + 2.118 2.749 2.105