ENSG00000170903

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301919 ENSG00000170903 HEK293_OSMI2_2hA HEK293_TMG_2hB MSANTD4 protein_coding protein_coding 7.844984 2.624222 13.09811 0.1452102 0.155279 2.315011 4.3475467 1.91383665 7.1720756 0.11647593 0.36337974 1.900415 0.61946667 0.733966667 0.54756667 -0.1864000000 0.103734247 0.002497158 FALSE  
ENST00000529805 ENSG00000170903 HEK293_OSMI2_2hA HEK293_TMG_2hB MSANTD4 protein_coding processed_transcript 7.844984 2.624222 13.09811 0.1452102 0.155279 2.315011 0.3342411 0.11968384 0.5865789 0.06532879 0.31207415 2.201714 0.06886667 0.043600000 0.04456667 0.0009666667 0.999376480 0.002497158 TRUE  
ENST00000530788 ENSG00000170903 HEK293_OSMI2_2hA HEK293_TMG_2hB MSANTD4 protein_coding protein_coding 7.844984 2.624222 13.09811 0.1452102 0.155279 2.315011 1.7236568 0.30521855 2.6144028 0.17049831 0.09302344 3.057565 0.16850417 0.115800000 0.19976667 0.0839666667 0.581589888 0.002497158 FALSE  
MSTRG.6229.4 ENSG00000170903 HEK293_OSMI2_2hA HEK293_TMG_2hB MSANTD4 protein_coding   7.844984 2.624222 13.09811 0.1452102 0.155279 2.315011 0.6490494 0.02369987 1.1735334 0.02369987 0.20232439 5.134214 0.06048333 0.009466667 0.08996667 0.0805000000 0.002497158 0.002497158 FALSE  
MSTRG.6229.5 ENSG00000170903 HEK293_OSMI2_2hA HEK293_TMG_2hB MSANTD4 protein_coding   7.844984 2.624222 13.09811 0.1452102 0.155279 2.315011 0.5621042 0.06740194 1.3625178 0.05045786 0.16366972 4.148311 0.05383333 0.023900000 0.10373333 0.0798333333 0.021995794 0.002497158 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170903 E001 0.2987644 0.0273704937 1.000000e+00   11 105975277 105975301 25 - 0.119 0.001 -7.684
ENSG00000170903 E002 0.6256415 0.0172671820 8.318081e-01 8.945885e-01 11 105979580 105979730 151 - 0.168 0.223 0.502
ENSG00000170903 E003 9.2259278 0.0856092240 1.111059e-02 3.143190e-02 11 105995623 105996049 427 - 0.771 1.281 1.884
ENSG00000170903 E004 5.5179677 0.1911482045 9.382369e-01 9.651987e-01 11 105996203 105996355 153 - 0.747 0.752 0.019
ENSG00000170903 E005 4.5079477 0.0357204891 9.854544e-02 1.882710e-01 11 105996356 105996396 41 - 0.585 0.888 1.242
ENSG00000170903 E006 4.2103292 0.0046835695 1.052420e-01 1.984669e-01 11 105996397 105996406 10 - 0.566 0.848 1.170
ENSG00000170903 E007 5.9481978 0.0727422361 3.111037e-01 4.535481e-01 11 105996407 105996526 120 - 0.721 0.922 0.788
ENSG00000170903 E008 3.4310098 0.0159334269 2.422980e-01 3.768882e-01 11 105996527 105996617 91 - 0.527 0.755 0.986
ENSG00000170903 E009 306.0485293 0.0038817926 2.781825e-08 3.151964e-07 11 106007899 106009582 1684 - 2.359 2.545 0.620
ENSG00000170903 E010 120.9469746 0.0003446867 1.165816e-03 4.524901e-03 11 106009583 106009983 401 - 2.023 1.945 -0.262
ENSG00000170903 E011 65.7631656 0.0005542678 3.760651e-03 1.247058e-02 11 106009984 106010110 127 - 1.767 1.656 -0.376
ENSG00000170903 E012 61.9767998 0.0004298120 4.797691e-03 1.536798e-02 11 106010456 106010584 129 - 1.740 1.629 -0.377
ENSG00000170903 E013 61.3575774 0.0009825808 2.355634e-02 5.889692e-02 11 106010585 106010702 118 - 1.732 1.649 -0.279
ENSG00000170903 E014 84.7923504 0.0004595873 6.309495e-04 2.646930e-03 11 106010703 106011067 365 - 1.875 1.759 -0.394
ENSG00000170903 E015 3.5641800 0.0050936035 3.422053e-01 4.862026e-01 11 106013946 106014041 96 - 0.619 0.479 -0.650
ENSG00000170903 E016 6.9624335 0.0078503397 5.764823e-01 7.019132e-01 11 106020962 106021098 137 - 0.845 0.803 -0.162
ENSG00000170903 E017 3.1011155 0.0047870570 1.690215e-01 2.869232e-01 11 106021099 106021101 3 - 0.602 0.369 -1.162
ENSG00000170903 E018 18.1162249 0.0010444405 3.006728e-01 4.424096e-01 11 106021102 106021835 734 - 1.217 1.159 -0.206
ENSG00000170903 E019 21.6952138 0.0130493164 1.961375e-01 3.213942e-01 11 106021836 106022121 286 - 1.296 1.199 -0.342
ENSG00000170903 E020 7.5168972 0.0772244872 9.921864e-01 9.992207e-01 11 106022122 106022194 73 - 0.855 0.886 0.122
ENSG00000170903 E021 10.9115778 0.0132968746 8.601536e-01 9.137886e-01 11 106022195 106022403 209 - 1.000 1.017 0.062