ENSG00000170871

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307659 ENSG00000170871 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA0232 protein_coding protein_coding 5.876812 2.322669 9.417595 0.2528091 0.3268011 2.014908 0.2678634 0.00000000 0.5114154 0.00000000 0.2633600 5.704361 0.05092500 0.000000000 0.0563000 0.0563000 6.902198e-02 6.677521e-16 FALSE TRUE
ENST00000425103 ENSG00000170871 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA0232 protein_coding protein_coding 5.876812 2.322669 9.417595 0.2528091 0.3268011 2.014908 4.1006045 2.21679198 5.5587186 0.20536617 0.2553000 1.322379 0.76638333 0.957733333 0.5898667 -0.3678667 6.677521e-16 6.677521e-16 FALSE TRUE
ENST00000503069 ENSG00000170871 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA0232 protein_coding processed_transcript 5.876812 2.322669 9.417595 0.2528091 0.3268011 2.014908 0.5661341 0.01146951 1.1797741 0.01146951 0.3534410 5.792254 0.06004167 0.004133333 0.1268333 0.1227000 1.799910e-03 6.677521e-16 FALSE TRUE
ENST00000508423 ENSG00000170871 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA0232 protein_coding protein_coding 5.876812 2.322669 9.417595 0.2528091 0.3268011 2.014908 0.1140334 0.00000000 0.5665268 0.00000000 0.2965729 5.849316 0.01179167 0.000000000 0.0582000 0.0582000 4.106732e-01 6.677521e-16   FALSE
MSTRG.24536.6 ENSG00000170871 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA0232 protein_coding   5.876812 2.322669 9.417595 0.2528091 0.3268011 2.014908 0.7564277 0.08090323 1.4468765 0.04359475 0.4087959 4.002403 0.09881250 0.032233333 0.1518667 0.1196333 7.304596e-02 6.677521e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170871 E001 0.0000000       4 6781375 6781828 454 +      
ENSG00000170871 E002 1.0373134 0.0119414464 9.214379e-02 1.784649e-01 4 6782642 6782726 85 + 0.340 0.000 -11.196
ENSG00000170871 E003 1.3297351 0.0100686642 4.640453e-02 1.027646e-01 4 6782727 6782731 5 + 0.402 0.000 -13.358
ENSG00000170871 E004 1.6242331 0.0083241145 2.389125e-02 5.958171e-02 4 6782732 6782744 13 + 0.457 0.000 -13.648
ENSG00000170871 E005 8.6203064 0.0028647003 6.648840e-03 2.031323e-02 4 6782745 6782841 97 + 0.984 0.677 -1.204
ENSG00000170871 E006 2.1285707 0.0382321163 3.815754e-02 8.765088e-02 4 6785406 6785561 156 + 0.305 0.731 2.107
ENSG00000170871 E007 0.2966881 0.0271599278 7.376753e-01   4 6804523 6804556 34 + 0.127 0.000 -11.052
ENSG00000170871 E008 1.1823723 0.0108734998 6.502703e-02 1.350831e-01 4 6804557 6804606 50 + 0.372 0.000 -13.190
ENSG00000170871 E009 40.5872585 0.0005621462 5.917511e-08 6.279715e-07 4 6824185 6824459 275 + 1.611 1.309 -1.038
ENSG00000170871 E010 44.9547732 0.0007653968 9.205955e-10 1.373909e-08 4 6824460 6824684 225 + 1.662 1.322 -1.166
ENSG00000170871 E011 32.5220322 0.0006472951 2.088413e-04 1.001781e-03 4 6842067 6842204 138 + 1.503 1.309 -0.670
ENSG00000170871 E012 0.1817044 0.0391571811 1.525494e-01   4 6855799 6855898 100 + 0.000 0.211 11.561
ENSG00000170871 E013 18.2623192 0.0011649141 8.254636e-03 2.442852e-02 4 6857164 6857230 67 + 1.262 1.088 -0.619
ENSG00000170871 E014 24.0885683 0.0009007833 2.717344e-04 1.264723e-03 4 6858425 6858506 82 + 1.387 1.150 -0.833
ENSG00000170871 E015 400.8859515 0.0003264877 9.573800e-29 1.441755e-26 4 6860901 6863728 2828 + 2.568 2.446 -0.406
ENSG00000170871 E016 97.6928173 0.0003195429 8.913608e-01 9.345961e-01 4 6863729 6864183 455 + 1.908 1.991 0.277
ENSG00000170871 E017 4.3340889 0.0997121064 5.395396e-01 6.707978e-01 4 6866192 6866263 72 + 0.691 0.617 -0.315
ENSG00000170871 E018 40.2210470 0.0070417630 8.957594e-01 9.374078e-01 4 6871574 6871682 109 + 1.532 1.606 0.253
ENSG00000170871 E019 35.8557493 0.0006024263 5.591106e-01 6.872607e-01 4 6876660 6876757 98 + 1.469 1.593 0.422
ENSG00000170871 E020 40.7147877 0.0005766912 2.359093e-01 3.694434e-01 4 6880787 6880913 127 + 1.512 1.669 0.534
ENSG00000170871 E021 111.8102439 0.0002748297 5.327105e-05 2.980960e-04 4 6880914 6881563 650 + 1.922 2.149 0.763
ENSG00000170871 E022 293.5256528 0.0134743168 4.393764e-12 9.689040e-11 4 6881564 6884170 2607 + 2.268 2.669 1.339