ENSG00000170854

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394198 ENSG00000170854 HEK293_OSMI2_2hA HEK293_TMG_2hB RIOX2 protein_coding protein_coding 36.27594 20.11118 48.29604 1.432395 0.2535376 1.263489 4.554598 2.038549 6.984194 0.1072699 0.3061982 1.7715557 0.11790417 0.10316667 0.14466667 0.04150000 0.1639612676 0.0005910998 FALSE TRUE
ENST00000503097 ENSG00000170854 HEK293_OSMI2_2hA HEK293_TMG_2hB RIOX2 protein_coding protein_coding 36.27594 20.11118 48.29604 1.432395 0.2535376 1.263489 1.595127 1.714425 1.297514 0.3420050 0.2258281 -0.3992888 0.05335000 0.08366667 0.02683333 -0.05683333 0.0005910998 0.0005910998   FALSE
ENST00000506682 ENSG00000170854 HEK293_OSMI2_2hA HEK293_TMG_2hB RIOX2 protein_coding retained_intron 36.27594 20.11118 48.29604 1.432395 0.2535376 1.263489 8.699110 6.074378 8.803837 0.8826698 0.8077697 0.5346604 0.24952083 0.29926667 0.18213333 -0.11713333 0.0267597321 0.0005910998 FALSE TRUE
ENST00000514314 ENSG00000170854 HEK293_OSMI2_2hA HEK293_TMG_2hB RIOX2 protein_coding nonsense_mediated_decay 36.27594 20.11118 48.29604 1.432395 0.2535376 1.263489 2.763251 1.695378 2.931277 0.3587352 0.2279013 0.7863510 0.08275833 0.08336667 0.06076667 -0.02260000 0.5360108876 0.0005910998 TRUE TRUE
MSTRG.23331.6 ENSG00000170854 HEK293_OSMI2_2hA HEK293_TMG_2hB RIOX2 protein_coding   36.27594 20.11118 48.29604 1.432395 0.2535376 1.263489 13.836976 6.509457 21.593814 0.5799987 0.4537075 1.7284623 0.36020833 0.32623333 0.44706667 0.12083333 0.0597389286 0.0005910998 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170854 E001 297.3778651 0.0015582080 7.729920e-06 5.268420e-05 3 97941818 97944405 2588 - 2.494 2.367 -0.422
ENSG00000170854 E002 83.5861103 0.0003878683 4.754752e-10 7.471791e-09 3 97944406 97944559 154 - 1.809 2.054 0.821
ENSG00000170854 E003 290.3108279 0.0020916968 8.818224e-05 4.664618e-04 3 97944560 97945176 617 - 2.401 2.514 0.378
ENSG00000170854 E004 198.8993500 0.0001827520 3.017198e-02 7.230673e-02 3 97945177 97945337 161 - 2.260 2.316 0.188
ENSG00000170854 E005 93.4111428 0.0005533008 3.962666e-01 5.400595e-01 3 97945338 97945342 5 - 1.944 1.977 0.112
ENSG00000170854 E006 20.5235691 0.0036844738 2.326105e-11 4.564673e-10 3 97945343 97945797 455 - 1.054 1.589 1.872
ENSG00000170854 E007 195.8688083 0.0015741891 2.974639e-01 4.388067e-01 3 97945798 97945887 90 - 2.262 2.295 0.108
ENSG00000170854 E008 152.5161435 0.0008053487 3.397725e-01 4.836950e-01 3 97947361 97947415 55 - 2.155 2.186 0.102
ENSG00000170854 E009 146.7956622 0.0003002550 8.577725e-01 9.121611e-01 3 97947416 97947449 34 - 2.153 2.148 -0.017
ENSG00000170854 E010 215.9093032 0.0002670855 6.639866e-01 7.719041e-01 3 97949844 97950012 169 - 2.322 2.311 -0.036
ENSG00000170854 E011 62.3061129 0.0003725123 4.200014e-01 5.632456e-01 3 97950013 97950015 3 - 1.768 1.806 0.127
ENSG00000170854 E012 0.8534295 0.0160823166 6.505539e-01 7.615832e-01 3 97950016 97950024 9 - 0.216 0.298 0.610
ENSG00000170854 E013 175.7063970 0.0002271405 5.019915e-01 6.381226e-01 3 97950786 97950888 103 - 2.234 2.214 -0.064
ENSG00000170854 E014 9.5072562 0.0241988979 9.208743e-01 9.540952e-01 3 97950889 97951183 295 - 1.002 1.013 0.041
ENSG00000170854 E015 12.4389965 0.0193522015 9.634364e-02 1.848867e-01 3 97952152 97952252 101 - 1.163 0.951 -0.771
ENSG00000170854 E016 13.1189121 0.0013862914 5.748324e-01 7.005731e-01 3 97954007 97954391 385 - 1.116 1.169 0.193
ENSG00000170854 E017 184.5163256 0.0002368454 2.639723e-01 4.019060e-01 3 97954392 97954495 104 - 2.257 2.226 -0.104
ENSG00000170854 E018 193.9592678 0.0001995331 1.542700e-01 2.674726e-01 3 97959051 97959179 129 - 2.283 2.245 -0.128
ENSG00000170854 E019 182.9084358 0.0022838837 8.367481e-02 1.653086e-01 3 97961589 97961708 120 - 2.265 2.204 -0.206
ENSG00000170854 E020 174.9216623 0.0034560594 5.901706e-01 7.130897e-01 3 97967162 97967256 95 - 2.233 2.208 -0.083
ENSG00000170854 E021 287.6769646 0.0006609847 7.981660e-02 1.592793e-01 3 97967257 97967632 376 - 2.454 2.410 -0.146
ENSG00000170854 E022 3.4814881 0.0140530209 6.506262e-01 7.616459e-01 3 97971590 97971913 324 - 0.668 0.596 -0.313
ENSG00000170854 E023 25.0979099 0.0017650130 9.606102e-01 9.791969e-01 3 97971914 97972380 467 - 1.396 1.392 -0.015
ENSG00000170854 E024 54.8689446 0.0005130966 2.393445e-06 1.830611e-05 3 97972381 97972457 77 - 1.801 1.543 -0.873