ENSG00000170832

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000300896 ENSG00000170832 HEK293_OSMI2_2hA HEK293_TMG_2hB USP32 protein_coding protein_coding 7.475551 4.130132 9.686019 0.6289326 0.2280714 1.227716 2.7714144 1.5801934 3.8815993 0.03433812 0.2468148 1.2911610 0.36777917 0.3971667 0.4024000 0.005233333 9.819978e-01 4.558278e-19 FALSE TRUE
ENST00000591768 ENSG00000170832 HEK293_OSMI2_2hA HEK293_TMG_2hB USP32 protein_coding protein_coding 7.475551 4.130132 9.686019 0.6289326 0.2280714 1.227716 0.2232669 0.0440990 0.6112254 0.04409900 0.0446363 3.5214432 0.02917500 0.0082000 0.0633000 0.055100000 7.317627e-03 4.558278e-19 FALSE TRUE
ENST00000592339 ENSG00000170832 HEK293_OSMI2_2hA HEK293_TMG_2hB USP32 protein_coding protein_coding 7.475551 4.130132 9.686019 0.6289326 0.2280714 1.227716 2.5928056 1.8002177 2.5474902 0.13833637 0.1090658 0.4985655 0.37951250 0.4487000 0.2627667 -0.185933333 2.187751e-02 4.558278e-19 FALSE TRUE
ENST00000593071 ENSG00000170832 HEK293_OSMI2_2hA HEK293_TMG_2hB USP32 protein_coding protein_coding 7.475551 4.130132 9.686019 0.6289326 0.2280714 1.227716 0.2942334 0.6652756 0.0000000 0.46298791 0.0000000 -6.0774045 0.05377083 0.1384667 0.0000000 -0.138466667 7.348950e-02 4.558278e-19 FALSE FALSE
MSTRG.14818.4 ENSG00000170832 HEK293_OSMI2_2hA HEK293_TMG_2hB USP32 protein_coding   7.475551 4.130132 9.686019 0.6289326 0.2280714 1.227716 1.1106714 0.0000000 2.1070544 0.00000000 0.1472282 7.7259146 0.11548750 0.0000000 0.2170667 0.217066667 4.558278e-19 4.558278e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170832 E001 120.4497193 0.0081911044 2.557533e-02 6.306965e-02 17 60177327 60179104 1778 - 2.017 2.139 0.408
ENSG00000170832 E002 5.1152836 0.0087835657 4.345616e-01 5.769039e-01 17 60179105 60179110 6 - 0.804 0.694 -0.442
ENSG00000170832 E003 21.7299167 0.0100135257 5.808220e-02 1.233452e-01 17 60179111 60179168 58 - 1.269 1.441 0.598
ENSG00000170832 E004 83.8849160 0.0047703030 1.106451e-07 1.115027e-06 17 60179169 60179428 260 - 1.798 2.067 0.907
ENSG00000170832 E005 63.1232827 0.0005035793 6.133538e-13 1.558428e-11 17 60180545 60180637 93 - 1.647 1.972 1.099
ENSG00000170832 E006 115.4577756 0.0004147667 5.904388e-11 1.081579e-09 17 60181324 60181748 425 - 1.957 2.180 0.748
ENSG00000170832 E007 30.1749516 0.0007053093 6.624945e-03 2.025198e-02 17 60183165 60183185 21 - 1.406 1.586 0.618
ENSG00000170832 E008 70.8685268 0.0004258480 5.038499e-04 2.174572e-03 17 60183186 60183453 268 - 1.775 1.929 0.520
ENSG00000170832 E009 52.3889422 0.0005395111 1.495196e-02 4.037694e-02 17 60185460 60185651 192 - 1.663 1.790 0.431
ENSG00000170832 E010 0.4375944 0.0263311943 3.091196e-01 4.513816e-01 17 60185652 60185933 282 - 0.216 0.000 -11.061
ENSG00000170832 E011 40.7192701 0.0005183607 9.305920e-02 1.799086e-01 17 60190563 60190683 121 - 1.566 1.667 0.343
ENSG00000170832 E012 39.6681646 0.0005671749 3.456855e-02 8.084096e-02 17 60192844 60192930 87 - 1.545 1.671 0.429
ENSG00000170832 E013 66.8521151 0.0003660948 2.978590e-01 4.392348e-01 17 60198260 60198444 185 - 1.793 1.846 0.178
ENSG00000170832 E014 63.3222117 0.0003726496 9.477281e-01 9.711184e-01 17 60205447 60205658 212 - 1.787 1.791 0.011
ENSG00000170832 E015 36.4219723 0.0006225197 5.721013e-01 6.982668e-01 17 60207021 60207132 112 - 1.540 1.580 0.138
ENSG00000170832 E016 0.5911862 0.0184176859 1.858183e-01 3.085333e-01 17 60207729 60208058 330 - 0.269 0.000 -11.476
ENSG00000170832 E017 21.8935688 0.0008776851 3.252258e-01 4.686544e-01 17 60208059 60208210 152 - 1.312 1.393 0.280
ENSG00000170832 E018 26.9438929 0.0007027866 6.656600e-01 7.733085e-01 17 60208654 60208828 175 - 1.434 1.410 -0.083
ENSG00000170832 E019 25.2924576 0.0007519100 1.772082e-01 2.975964e-01 17 60209370 60209416 47 - 1.431 1.337 -0.323
ENSG00000170832 E020 28.5958128 0.0007157715 2.215481e-01 3.522587e-01 17 60209417 60209543 127 - 1.479 1.401 -0.270
ENSG00000170832 E021 21.5562571 0.0008933452 2.318514e-02 5.813453e-02 17 60211013 60211118 106 - 1.391 1.212 -0.624
ENSG00000170832 E022 27.0384047 0.0010187813 2.152836e-01 3.447489e-01 17 60211376 60211514 139 - 1.457 1.375 -0.285
ENSG00000170832 E023 20.4426515 0.0009146240 5.599374e-01 6.880037e-01 17 60212024 60212098 75 - 1.325 1.285 -0.142
ENSG00000170832 E024 12.7850980 0.0014980240 3.645134e-01 5.088607e-01 17 60213581 60213662 82 - 1.092 1.185 0.333
ENSG00000170832 E025 26.4884214 0.0007545869 1.185233e-01 2.178233e-01 17 60214620 60214774 155 - 1.454 1.347 -0.370
ENSG00000170832 E026 0.0000000       17 60219571 60219627 57 -      
ENSG00000170832 E027 1.0287926 0.2661711383 9.294717e-01 9.595995e-01 17 60219628 60219635 8 - 0.316 0.293 -0.152
ENSG00000170832 E028 2.0702586 0.0067524287 1.587596e-01 2.734801e-01 17 60219636 60219669 34 - 0.553 0.298 -1.383
ENSG00000170832 E029 21.2300589 0.0009365872 2.410862e-02 6.003608e-02 17 60219670 60219679 10 - 1.379 1.199 -0.631
ENSG00000170832 E030 38.0806548 0.0025596878 1.565799e-03 5.848847e-03 17 60219680 60219787 108 - 1.632 1.426 -0.705
ENSG00000170832 E031 46.8965410 0.0005127826 7.841653e-04 3.203057e-03 17 60222409 60222549 141 - 1.716 1.532 -0.626
ENSG00000170832 E032 44.7745234 0.0005375144 1.237191e-03 4.766646e-03 17 60223411 60223586 176 - 1.694 1.513 -0.617
ENSG00000170832 E033 35.9740756 0.0005772920 5.017535e-03 1.597897e-02 17 60226039 60226182 144 - 1.600 1.426 -0.596
ENSG00000170832 E034 21.0590322 0.0009192897 2.375480e-01 3.713068e-01 17 60226183 60226231 49 - 1.351 1.262 -0.311
ENSG00000170832 E035 31.4624219 0.0006550674 1.083283e-02 3.076508e-02 17 60236138 60236240 103 - 1.543 1.375 -0.577
ENSG00000170832 E036 0.1451727 0.0434939644 1.000000e+00   17 60249058 60249753 696 - 0.084 0.000 -9.476
ENSG00000170832 E037 27.6628286 0.0007297274 1.654996e-02 4.394896e-02 17 60252381 60252442 62 - 1.486 1.317 -0.583
ENSG00000170832 E038 27.4113453 0.0007557943 4.428857e-02 9.891233e-02 17 60255175 60255258 84 - 1.476 1.337 -0.481
ENSG00000170832 E039 0.0000000       17 60256631 60256700 70 -      
ENSG00000170832 E040 30.9975347 0.0006691958 8.676639e-03 2.547522e-02 17 60265412 60265474 63 - 1.540 1.366 -0.600
ENSG00000170832 E041 36.3703674 0.0006161193 7.509872e-04 3.082713e-03 17 60265976 60266091 116 - 1.614 1.401 -0.729
ENSG00000170832 E042 32.3996524 0.0324844369 3.398347e-02 7.972639e-02 17 60269450 60269557 108 - 1.566 1.334 -0.799
ENSG00000170832 E043 36.7799260 0.0076761651 1.019020e-02 2.923365e-02 17 60271350 60271481 132 - 1.612 1.419 -0.662
ENSG00000170832 E044 33.9032548 0.0006502832 1.348753e-03 5.138812e-03 17 60288523 60288682 160 - 1.583 1.375 -0.716
ENSG00000170832 E045 29.8675933 0.0028557154 7.716497e-05 4.146435e-04 17 60294683 60294801 119 - 1.550 1.250 -1.039
ENSG00000170832 E046 0.0000000       17 60301450 60301598 149 -      
ENSG00000170832 E047 27.3129016 0.0007447881 1.075792e-03 4.220625e-03 17 60301599 60301704 106 - 1.501 1.262 -0.827
ENSG00000170832 E048 0.0000000       17 60304907 60305043 137 -      
ENSG00000170832 E049 0.0000000       17 60305143 60305228 86 -      
ENSG00000170832 E050 33.9488745 0.0016657528 2.288701e-05 1.399572e-04 17 60345481 60345608 128 - 1.602 1.307 -1.018
ENSG00000170832 E051 21.7940638 0.0009708265 2.624519e-04 1.226552e-03 17 60391882 60392230 349 - 1.416 1.109 -1.081
ENSG00000170832 E052 0.1451727 0.0434939644 1.000000e+00   17 60392339 60392408 70 - 0.084 0.000 -9.476
ENSG00000170832 E053 0.0000000       17 60421208 60421551 344 -      
ENSG00000170832 E054 0.0000000       17 60422246 60422470 225 -