ENSG00000170802

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340553 ENSG00000170802 HEK293_OSMI2_2hA HEK293_TMG_2hB FOXN2 protein_coding protein_coding 2.878713 0.4691458 4.421238 0.0839936 0.2118839 3.209173 0.6369597 0.0000000 0.9544096 0.0000000 0.1484315 6.591574 0.1335583 0 0.21353333 0.21353333 0.001032838 0.001032838 FALSE TRUE
ENST00000413569 ENSG00000170802 HEK293_OSMI2_2hA HEK293_TMG_2hB FOXN2 protein_coding protein_coding 2.878713 0.4691458 4.421238 0.0839936 0.2118839 3.209173 0.6119900 0.0000000 0.3696281 0.0000000 0.3696281 5.246515 0.1035500 0 0.07813333 0.07813333 1.000000000 0.001032838 FALSE TRUE
MSTRG.18356.1 ENSG00000170802 HEK293_OSMI2_2hA HEK293_TMG_2hB FOXN2 protein_coding   2.878713 0.4691458 4.421238 0.0839936 0.2118839 3.209173 1.6297629 0.4691458 3.0971999 0.0839936 0.3251772 2.697078 0.7628917 1 0.70833333 -0.29166667 0.006984536 0.001032838 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170802 E001 0.0000000       2 48314621 48314636 16 +      
ENSG00000170802 E002 0.5911862 0.0193874923 1.000000e+00 1.000000e+00 2 48314637 48314681 45 + 0.156 0.000 -8.849
ENSG00000170802 E003 11.0167291 0.0020009468 1.043109e-03 4.107970e-03 2 48314682 48314814 133 + 0.950 0.296 -3.017
ENSG00000170802 E004 3.8523379 0.0043086228 2.877852e-02 6.955774e-02 2 48328561 48328702 142 + 0.582 0.000 -11.945
ENSG00000170802 E005 39.3057152 0.0006154382 1.203804e-05 7.849692e-05 2 48346201 48346751 551 + 1.454 1.032 -1.489
ENSG00000170802 E006 16.1920040 0.0075445865 2.124061e-02 5.409435e-02 2 48359047 48359147 101 + 1.089 0.770 -1.207
ENSG00000170802 E007 13.0567101 0.0014325778 3.071708e-02 7.336154e-02 2 48362643 48362707 65 + 1.005 0.691 -1.220
ENSG00000170802 E008 10.9791904 0.0015611866 3.119267e-02 7.427641e-02 2 48373292 48373360 69 + 0.939 0.594 -1.393
ENSG00000170802 E009 238.3905786 0.0037371613 2.228263e-12 5.167558e-11 2 48374920 48379295 4376 + 2.171 2.327 0.522