ENSG00000170791

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000303759 ENSG00000170791 HEK293_OSMI2_2hA HEK293_TMG_2hB CHCHD7 protein_coding protein_coding 34.49502 38.51168 38.98753 6.296815 1.261706 0.01771236 3.883262 2.013260 8.331890 0.8484542 0.4023550 2.0436927 0.10725000 0.06030000 0.21353333 0.15323333 2.197852e-02 1.451342e-12 FALSE FALSE
ENST00000355315 ENSG00000170791 HEK293_OSMI2_2hA HEK293_TMG_2hB CHCHD7 protein_coding protein_coding 34.49502 38.51168 38.98753 6.296815 1.261706 0.01771236 14.304738 20.690352 10.240368 3.7265482 0.1880887 -1.0139796 0.41973750 0.53636667 0.26316667 -0.27320000 1.451342e-12 1.451342e-12 FALSE FALSE
ENST00000396723 ENSG00000170791 HEK293_OSMI2_2hA HEK293_TMG_2hB CHCHD7 protein_coding protein_coding 34.49502 38.51168 38.98753 6.296815 1.261706 0.01771236 2.103243 3.770318 0.000000 1.8866472 0.0000000 -8.5623638 0.06356667 0.08896667 0.00000000 -0.08896667 1.242638e-01 1.451342e-12 FALSE FALSE
ENST00000517933 ENSG00000170791 HEK293_OSMI2_2hA HEK293_TMG_2hB CHCHD7 protein_coding protein_coding 34.49502 38.51168 38.98753 6.296815 1.261706 0.01771236 1.377528 0.635317 2.812687 0.2065891 0.2646942 2.1289891 0.04026667 0.01640000 0.07260000 0.05620000 2.638619e-04 1.451342e-12   FALSE
ENST00000518801 ENSG00000170791 HEK293_OSMI2_2hA HEK293_TMG_2hB CHCHD7 protein_coding protein_coding 34.49502 38.51168 38.98753 6.296815 1.261706 0.01771236 1.985294 1.104704 2.525488 0.6683964 0.4600012 1.1856022 0.05647083 0.02693333 0.06430000 0.03736667 5.466834e-01 1.451342e-12   FALSE
ENST00000521831 ENSG00000170791 HEK293_OSMI2_2hA HEK293_TMG_2hB CHCHD7 protein_coding protein_coding 34.49502 38.51168 38.98753 6.296815 1.261706 0.01771236 3.177559 4.424184 2.108422 0.5652777 0.4502067 -1.0656789 0.09243333 0.11630000 0.05343333 -0.06286667 9.124505e-03 1.451342e-12   FALSE
ENST00000523975 ENSG00000170791 HEK293_OSMI2_2hA HEK293_TMG_2hB CHCHD7 protein_coding protein_coding 34.49502 38.51168 38.98753 6.296815 1.261706 0.01771236 4.161003 3.776320 7.868739 0.6205118 0.3737029 1.0571686 0.11745833 0.09886667 0.20180000 0.10293333 4.670706e-05 1.451342e-12   FALSE
MSTRG.31531.2 ENSG00000170791 HEK293_OSMI2_2hA HEK293_TMG_2hB CHCHD7 protein_coding   34.49502 38.51168 38.98753 6.296815 1.261706 0.01771236 1.703826 1.423325 2.424220 0.3794450 0.3666887 0.7640933 0.05017917 0.03756667 0.06260000 0.02503333 3.753582e-01 1.451342e-12   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170791 E001 2.102521 0.0070719507 3.398746e-01 4.838018e-01 8 56211686 56211709 24 + 0.586 0.408 -0.875
ENSG00000170791 E002 4.264288 0.0042181312 8.572450e-01 9.118408e-01 8 56211710 56211755 46 + 0.739 0.690 -0.205
ENSG00000170791 E003 8.680192 0.0024302314 6.799684e-01 7.840075e-01 8 56211756 56211785 30 + 1.016 0.944 -0.269
ENSG00000170791 E004 11.699452 0.0015625959 7.872064e-01 8.637182e-01 8 56211786 56211788 3 + 1.094 1.094 -0.001
ENSG00000170791 E005 22.744768 0.0008221375 5.425554e-02 1.166956e-01 8 56211789 56211797 9 + 1.465 1.300 -0.572
ENSG00000170791 E006 38.053737 0.0005736801 8.476989e-06 5.725685e-05 8 56211798 56211798 1 + 1.739 1.463 -0.943
ENSG00000170791 E007 221.691902 0.0001927996 6.087362e-04 2.565102e-03 8 56211799 56211807 9 + 2.299 2.354 0.184
ENSG00000170791 E008 244.052988 0.0001933705 7.753184e-05 4.163787e-04 8 56211808 56211809 2 + 2.335 2.399 0.212
ENSG00000170791 E009 350.114670 0.0002240450 4.495058e-10 7.102379e-09 8 56211810 56211837 28 + 2.469 2.564 0.316
ENSG00000170791 E010 4.772603 0.0032765778 4.113428e-09 5.440356e-08 8 56211838 56212174 337 + 1.108 0.250 -3.925
ENSG00000170791 E011 10.374045 0.0036070825 6.089625e-19 3.443765e-17 8 56212175 56212761 587 + 1.433 0.361 -4.330
ENSG00000170791 E012 217.259268 0.0022249396 1.138827e-11 2.349166e-10 8 56212762 56212889 128 + 2.472 2.218 -0.847
ENSG00000170791 E013 86.083863 0.0016986460 1.695398e-04 8.330863e-04 8 56212890 56212909 20 + 2.041 1.851 -0.637
ENSG00000170791 E014 30.218340 0.0008119273 1.254497e-29 2.038256e-27 8 56212910 56214427 1518 + 1.819 1.036 -2.717
ENSG00000170791 E015 3.896820 0.0074526281 4.434478e-05 2.530265e-04 8 56214428 56214444 17 + 0.981 0.361 -2.723
ENSG00000170791 E016 4.599768 0.0123764006 2.456433e-06 1.874200e-05 8 56214445 56214517 73 + 1.064 0.361 -3.034
ENSG00000170791 E017 5.095916 0.0461988245 1.259465e-04 6.410068e-04 8 56214518 56214597 80 + 1.079 0.447 -2.615
ENSG00000170791 E018 578.050948 0.0001336282 3.147382e-14 9.624891e-13 8 56214598 56214667 70 + 2.695 2.779 0.282
ENSG00000170791 E019 10.962624 0.0017360077 2.624149e-14 8.115199e-13 8 56214668 56215578 911 + 1.413 0.586 -3.124
ENSG00000170791 E020 104.437359 0.0002736319 1.859731e-01 3.087118e-01 8 56216389 56216432 44 + 1.999 2.017 0.060
ENSG00000170791 E021 582.996690 0.0001221961 1.315071e-20 9.033225e-19 8 56216433 56216506 74 + 2.680 2.791 0.367
ENSG00000170791 E022 430.055226 0.0001362876 4.490771e-11 8.398451e-10 8 56216507 56216531 25 + 2.565 2.651 0.287
ENSG00000170791 E023 8.186877 0.0020754051 2.418865e-11 4.734933e-10 8 56216532 56216679 148 + 1.296 0.488 -3.175
ENSG00000170791 E024 11.622966 0.0015379650 5.731226e-08 6.097059e-07 8 56216680 56216754 75 + 1.362 0.810 -2.015
ENSG00000170791 E025 6.595187 0.0043042410 1.272461e-06 1.033456e-05 8 56216755 56216893 139 + 1.172 0.555 -2.420
ENSG00000170791 E026 1235.320117 0.0016199711 5.903539e-09 7.608734e-08 8 56217331 56218809 1479 + 3.157 3.022 -0.450