ENSG00000170759

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302418 ENSG00000170759 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF5B protein_coding protein_coding 26.71806 5.00329 50.96463 0.3276481 1.556606 3.34595 18.73729 5.00329 35.21115 0.3276481 1.111623 2.812613 0.8291750 1 0.6914667 -0.3085333 2.851506e-25 2.851506e-25 FALSE TRUE
MSTRG.3757.3 ENSG00000170759 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF5B protein_coding   26.71806 5.00329 50.96463 0.3276481 1.556606 3.34595 7.70111 0.00000 15.31896 0.0000000 1.327247 10.582044 0.1633125 0 0.3000667 0.3000667 3.821069e-25 2.851506e-25 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170759 E001 1036.59329 0.0413643666 9.251181e-07 7.732323e-06 10 32009015 32011145 2131 - 2.694 3.210 1.718
ENSG00000170759 E002 55.78868 0.0018693100 5.678364e-06 3.991043e-05 10 32011146 32011202 57 - 1.463 1.867 1.374
ENSG00000170759 E003 205.60864 0.0002000483 7.736870e-03 2.311799e-02 10 32011203 32011516 314 - 2.051 2.258 0.693
ENSG00000170759 E004 197.83023 0.0022785000 1.635716e-01 2.797800e-01 10 32015509 32015659 151 - 2.054 2.096 0.142
ENSG00000170759 E005 168.40624 0.0019026592 8.115228e-01 8.803788e-01 10 32017143 32017206 64 - 1.979 2.076 0.325
ENSG00000170759 E006 260.12754 0.0007135857 2.824355e-01 4.224524e-01 10 32017207 32017359 153 - 2.161 2.308 0.491
ENSG00000170759 E007 242.77655 0.0008429157 9.948032e-01 1.000000e+00 10 32018052 32018156 105 - 2.135 2.242 0.359
ENSG00000170759 E008 234.60407 0.0010044528 8.844747e-01 9.301662e-01 10 32018316 32018387 72 - 2.121 2.222 0.341
ENSG00000170759 E009 238.63217 0.0030916925 5.197895e-01 6.538683e-01 10 32018502 32018562 61 - 2.130 2.210 0.267
ENSG00000170759 E010 302.55896 0.0007833532 1.821067e-01 3.038539e-01 10 32019858 32019959 102 - 2.235 2.295 0.201
ENSG00000170759 E011 286.24162 0.0001987005 5.447908e-02 1.170890e-01 10 32021022 32021131 110 - 2.213 2.253 0.134
ENSG00000170759 E012 213.32965 0.0011178927 6.946223e-02 1.424672e-01 10 32021226 32021287 62 - 2.087 2.116 0.097
ENSG00000170759 E013 249.89398 0.0001672112 1.870215e-06 1.464621e-05 10 32022140 32022257 118 - 2.165 2.080 -0.287
ENSG00000170759 E014 279.26178 0.0002625391 7.563149e-05 4.072582e-04 10 32022848 32023033 186 - 2.210 2.168 -0.138
ENSG00000170759 E015 94.86028 0.0003391518 8.614381e-01 9.146166e-01 10 32023034 32023036 3 - 1.730 1.846 0.394
ENSG00000170759 E016 247.07171 0.0001686274 3.530335e-02 8.223326e-02 10 32028428 32028571 144 - 2.151 2.178 0.092
ENSG00000170759 E017 287.30859 0.0001514202 1.422175e-04 7.130522e-04 10 32031073 32031279 207 - 2.222 2.191 -0.104
ENSG00000170759 E018 166.74066 0.0003031791 2.592778e-04 1.213814e-03 10 32032706 32032774 69 - 1.991 1.917 -0.247
ENSG00000170759 E019 262.75660 0.0011115442 4.021211e-06 2.923166e-05 10 32033845 32034038 194 - 2.189 2.100 -0.299
ENSG00000170759 E020 203.16908 0.0003021239 7.360460e-07 6.293064e-06 10 32034690 32034838 149 - 2.079 1.957 -0.410
ENSG00000170759 E021 205.49802 0.0196878315 1.174859e-03 4.556078e-03 10 32035522 32035667 146 - 2.086 1.932 -0.516
ENSG00000170759 E022 165.88611 0.0273209951 5.689419e-03 1.778937e-02 10 32035890 32035994 105 - 1.995 1.844 -0.505
ENSG00000170759 E023 194.82899 0.0002140283 1.150136e-09 1.685671e-08 10 32037254 32037378 125 - 2.065 1.873 -0.645
ENSG00000170759 E024 146.58587 0.0010120853 4.498394e-08 4.896054e-07 10 32037520 32037607 88 - 1.945 1.726 -0.737
ENSG00000170759 E025 108.95975 0.0255645862 1.789914e-02 4.691978e-02 10 32038163 32038218 56 - 1.812 1.685 -0.430
ENSG00000170759 E026 71.64883 0.0030556758 6.343672e-03 1.951786e-02 10 32038778 32038826 49 - 1.632 1.516 -0.396
ENSG00000170759 E027 111.06126 0.0035277024 2.320865e-03 8.216184e-03 10 32039327 32039431 105 - 1.818 1.717 -0.340
ENSG00000170759 E028 110.95514 0.0031015946 3.530095e-06 2.602101e-05 10 32040384 32040457 74 - 1.826 1.598 -0.772
ENSG00000170759 E029 139.18249 0.0012552301 1.228788e-14 3.990917e-13 10 32048464 32048551 88 - 1.932 1.500 -1.464
ENSG00000170759 E030 245.09937 0.0022971451 1.118859e-13 3.156583e-12 10 32055848 32056425 578 - 2.169 1.888 -0.944