ENSG00000170638

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380909 ENSG00000170638 HEK293_OSMI2_2hA HEK293_TMG_2hB TRABD protein_coding protein_coding 69.62957 105.948 43.84437 8.686687 1.192439 -1.2727 34.194485 67.020462 15.790547 5.736695 0.1391243 -2.08484239 0.4423417 0.6326667 0.36063333 -0.27203333 7.654659e-21 7.654659e-21 FALSE TRUE
ENST00000463233 ENSG00000170638 HEK293_OSMI2_2hA HEK293_TMG_2hB TRABD protein_coding retained_intron 69.62957 105.948 43.84437 8.686687 1.192439 -1.2727 15.961142 17.037752 11.439439 2.730560 0.3795251 -0.57430460 0.2465458 0.1598667 0.26163333 0.10176667 1.225119e-02 7.654659e-21 TRUE TRUE
MSTRG.22363.2 ENSG00000170638 HEK293_OSMI2_2hA HEK293_TMG_2hB TRABD protein_coding   69.62957 105.948 43.84437 8.686687 1.192439 -1.2727 5.564934 6.166614 3.491263 0.426694 1.7655682 -0.81894069 0.0958250 0.0596000 0.07843333 0.01883333 9.575165e-01 7.654659e-21 FALSE TRUE
MSTRG.22363.3 ENSG00000170638 HEK293_OSMI2_2hA HEK293_TMG_2hB TRABD protein_coding   69.62957 105.948 43.84437 8.686687 1.192439 -1.2727 7.342004 7.925754 8.463849 1.303296 1.6442646 0.09465006 0.1142167 0.0741000 0.19316667 0.11906667 1.441756e-02 7.654659e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170638 E001 0.0000000       22 50185887 50185890 4 +      
ENSG00000170638 E002 0.0000000       22 50185891 50185898 8 +      
ENSG00000170638 E003 0.3634088 0.3879779089 7.473043e-01   22 50185899 50185902 4 + 0.001 0.147 8.446
ENSG00000170638 E004 0.7665583 0.1920411732 2.891165e-01 4.297987e-01 22 50185903 50185906 4 + 0.000 0.258 11.420
ENSG00000170638 E005 6.4035559 0.0994063385 3.700589e-02 8.548120e-02 22 50185907 50185912 6 + 1.045 0.689 -1.377
ENSG00000170638 E006 9.6238408 0.0416472527 2.758647e-03 9.548489e-03 22 50185913 50185916 4 + 1.229 0.823 -1.496
ENSG00000170638 E007 13.4174136 0.0580429189 2.101002e-03 7.537142e-03 22 50185917 50185917 1 + 1.368 0.944 -1.520
ENSG00000170638 E008 230.0317540 0.0064007140 1.748501e-01 2.944949e-01 22 50185918 50185976 59 + 2.331 2.278 -0.177
ENSG00000170638 E009 65.3578126 0.0015090651 2.526741e-06 1.922964e-05 22 50185977 50186001 25 + 1.906 1.680 -0.764
ENSG00000170638 E010 6.7306707 0.0337149294 4.569234e-02 1.014661e-01 22 50186002 50186005 4 + 1.024 0.734 -1.115
ENSG00000170638 E011 4.8457235 0.1698767022 9.767581e-04 3.880303e-03 22 50190598 50190648 51 + 1.085 0.432 -2.713
ENSG00000170638 E012 8.7104928 0.0047108637 8.622039e-02 1.693487e-01 22 50193014 50193026 13 + 1.065 0.869 -0.731
ENSG00000170638 E013 367.0738563 0.0025010827 6.438530e-02 1.340160e-01 22 50193027 50193093 67 + 2.529 2.481 -0.163
ENSG00000170638 E014 500.9705969 0.0012883597 1.180990e-03 4.576856e-03 22 50193576 50193654 79 + 2.678 2.609 -0.229
ENSG00000170638 E015 844.9653419 0.0001488865 4.787012e-05 2.709708e-04 22 50194340 50194506 167 + 2.890 2.838 -0.170
ENSG00000170638 E016 745.8387913 0.0001217674 2.360914e-01 3.696449e-01 22 50194900 50195040 141 + 2.806 2.794 -0.039
ENSG00000170638 E017 10.3843087 0.0028557315 7.372897e-04 3.033364e-03 22 50196893 50197240 348 + 1.228 0.880 -1.272
ENSG00000170638 E018 708.6125753 0.0001290424 1.765591e-01 2.967721e-01 22 50197241 50197351 111 + 2.754 2.781 0.090
ENSG00000170638 E019 7.6944678 0.0023389466 3.035130e-05 1.803910e-04 22 50197352 50197436 85 + 1.185 0.715 -1.772
ENSG00000170638 E020 17.1051348 0.0010275355 2.882205e-04 1.332028e-03 22 50197437 50197448 12 + 1.396 1.093 -1.068
ENSG00000170638 E021 737.5305220 0.0004612580 7.397787e-01 8.293982e-01 22 50197449 50197588 140 + 2.785 2.798 0.044
ENSG00000170638 E022 21.6499235 0.0008437819 6.063662e-12 1.307469e-10 22 50197589 50197822 234 + 1.605 1.100 -1.760
ENSG00000170638 E023 281.7884177 0.0060907490 7.276105e-01 8.202654e-01 22 50197823 50197826 4 + 2.386 2.379 -0.024
ENSG00000170638 E024 758.2626206 0.0009121530 4.800937e-02 1.056504e-01 22 50197827 50197995 169 + 2.829 2.800 -0.098
ENSG00000170638 E025 120.6778789 0.0042371144 6.725277e-12 1.440945e-10 22 50197996 50198074 79 + 2.219 1.917 -1.011
ENSG00000170638 E026 624.6284790 0.0001357144 1.866642e-02 4.859888e-02 22 50198075 50198186 112 + 2.744 2.712 -0.108
ENSG00000170638 E027 596.6027562 0.0013410998 2.614605e-01 3.990975e-01 22 50198345 50198515 171 + 2.675 2.711 0.118
ENSG00000170638 E028 1146.9353569 0.0003726760 1.085358e-20 7.565040e-19 22 50198516 50199115 600 + 2.870 3.016 0.485
ENSG00000170638 E029 1131.2689251 0.0018476611 3.166982e-09 4.278278e-08 22 50199116 50199598 483 + 2.868 3.013 0.481