ENSG00000170606

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000304858 ENSG00000170606 HEK293_OSMI2_2hA HEK293_TMG_2hB HSPA4 protein_coding protein_coding 74.81473 35.05089 115.0467 1.173381 2.664579 1.714411 61.162460 31.316507 93.385094 1.4495210 1.7809887 1.575963 0.84024167 0.8927 0.81186667 -0.08083333 2.609234e-03 4.792275e-40 FALSE TRUE
ENST00000504328 ENSG00000170606 HEK293_OSMI2_2hA HEK293_TMG_2hB HSPA4 protein_coding processed_transcript 74.81473 35.05089 115.0467 1.173381 2.664579 1.714411 6.625443 0.000000 12.069437 0.0000000 1.1003991 10.238337 0.06055000 0.0000 0.10463333 0.10463333 4.792275e-40 4.792275e-40 FALSE FALSE
MSTRG.26924.4 ENSG00000170606 HEK293_OSMI2_2hA HEK293_TMG_2hB HSPA4 protein_coding   74.81473 35.05089 115.0467 1.173381 2.664579 1.714411 6.281254 3.095969 8.489927 0.3488456 0.3779862 1.452407 0.08824167 0.0892 0.07393333 -0.01526667 6.782469e-01 4.792275e-40 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170606 E001 5.5369532 0.0037633033 2.031955e-01 3.302233e-01 5 133051157 133051959 803 + 0.717 0.895 0.702
ENSG00000170606 E002 6.9127599 0.0226141504 7.706162e-01 8.518949e-01 5 133051960 133051965 6 + 0.871 0.835 -0.137
ENSG00000170606 E003 34.9887042 0.0321386775 7.435812e-01 8.321916e-01 5 133051966 133051987 22 + 1.504 1.552 0.164
ENSG00000170606 E004 43.0474683 0.0423228729 8.593398e-01 9.132589e-01 5 133051988 133052002 15 + 1.595 1.635 0.135
ENSG00000170606 E005 46.8753882 0.0310776236 8.882073e-01 9.325413e-01 5 133052003 133052010 8 + 1.635 1.663 0.096
ENSG00000170606 E006 51.0965315 0.0345289001 9.173434e-01 9.517934e-01 5 133052011 133052012 2 + 1.679 1.685 0.019
ENSG00000170606 E007 53.5068923 0.0342544597 8.088353e-01 8.786055e-01 5 133052013 133052014 2 + 1.704 1.695 -0.032
ENSG00000170606 E008 567.0608839 0.0078965975 4.828762e-04 2.094645e-03 5 133052015 133052357 343 + 2.765 2.610 -0.516
ENSG00000170606 E009 282.3664800 0.0015876325 1.227036e-08 1.488686e-07 5 133064980 133065037 58 + 2.468 2.297 -0.568
ENSG00000170606 E010 554.5774445 0.0021736047 1.356159e-08 1.631032e-07 5 133067417 133067557 141 + 2.756 2.602 -0.514
ENSG00000170606 E011 613.9474998 0.0015273681 2.679558e-06 2.028022e-05 5 133070374 133070496 123 + 2.789 2.680 -0.363
ENSG00000170606 E012 532.5957570 0.0005559990 2.725973e-09 3.732490e-08 5 133073230 133073329 100 + 2.728 2.613 -0.383
ENSG00000170606 E013 669.1597854 0.0003683185 1.766186e-16 7.366769e-15 5 133073993 133074126 134 + 2.834 2.694 -0.466
ENSG00000170606 E014 0.1451727 0.0427996266 1.000000e+00   5 133076043 133076180 138 + 0.079 0.001 -6.723
ENSG00000170606 E015 1059.8718254 0.0010945718 1.972966e-13 5.377249e-12 5 133076654 133076898 245 + 3.033 2.893 -0.464
ENSG00000170606 E016 381.6908267 0.0008641909 1.635587e-15 6.014293e-14 5 133086782 133086783 2 + 2.603 2.407 -0.655
ENSG00000170606 E017 588.3504727 0.0011676645 7.562702e-13 1.893144e-11 5 133086784 133086858 75 + 2.783 2.620 -0.541
ENSG00000170606 E018 751.1813901 0.0006890853 1.102584e-07 1.111484e-06 5 133088404 133088555 152 + 2.871 2.777 -0.313
ENSG00000170606 E019 549.3751588 0.0016288877 4.930131e-01 6.300882e-01 5 133089055 133089161 107 + 2.712 2.701 -0.036
ENSG00000170606 E020 726.8560023 0.0005784939 1.393416e-02 3.807291e-02 5 133089562 133089695 134 + 2.842 2.805 -0.123
ENSG00000170606 E021 1193.3234573 0.0002660202 1.544412e-02 4.150013e-02 5 133091193 133091374 182 + 3.053 3.030 -0.078
ENSG00000170606 E022 494.4490387 0.0001207746 1.962516e-02 5.068474e-02 5 133092700 133092702 3 + 2.675 2.642 -0.110
ENSG00000170606 E023 857.4850764 0.0019560255 3.537169e-01 4.979758e-01 5 133092703 133092789 87 + 2.907 2.895 -0.042
ENSG00000170606 E024 1115.3511135 0.0007367620 9.021767e-01 9.416683e-01 5 133096098 133096250 153 + 3.014 3.025 0.039
ENSG00000170606 E025 1064.5022604 0.0001394814 1.510919e-05 9.638004e-05 5 133097161 133097286 126 + 2.976 3.039 0.209
ENSG00000170606 E026 838.5556542 0.0001468662 1.485314e-20 1.014377e-18 5 133099545 133099652 108 + 2.846 2.982 0.453
ENSG00000170606 E027 4.4955160 0.0097462271 3.871845e-01 5.313283e-01 5 133101596 133101737 142 + 0.664 0.798 0.547
ENSG00000170606 E028 3.5699641 0.0044195076 8.555597e-02 1.683037e-01 5 133101738 133101758 21 + 0.533 0.798 1.130
ENSG00000170606 E029 906.2590363 0.0003633672 7.826558e-22 6.106746e-20 5 133101759 133101878 120 + 2.873 3.025 0.506
ENSG00000170606 E030 443.3785662 0.0003712189 1.009089e-15 3.807387e-14 5 133103865 133103867 3 + 2.557 2.723 0.552
ENSG00000170606 E031 1014.9260952 0.0005765920 1.181235e-24 1.248780e-22 5 133103868 133104026 159 + 2.915 3.086 0.569
ENSG00000170606 E032 2031.0720840 0.0030266546 4.521911e-11 8.452516e-10 5 133104233 133106449 2217 + 3.213 3.389 0.586