ENSG00000170581

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314128 ENSG00000170581 HEK293_OSMI2_2hA HEK293_TMG_2hB STAT2 protein_coding protein_coding 13.28106 11.33604 11.80173 0.5567184 0.195527 0.0580309 0.8542421 1.0530376 0.000000 0.5899355 0.00000000 -6.7320488 0.06570833 0.08896667 0.0000000 -0.08896667 0.17475684 4.856213e-05 FALSE TRUE
ENST00000556539 ENSG00000170581 HEK293_OSMI2_2hA HEK293_TMG_2hB STAT2 protein_coding processed_transcript 13.28106 11.33604 11.80173 0.5567184 0.195527 0.0580309 4.1274756 5.1137257 3.003145 0.2331046 0.44883815 -0.7659234 0.31553333 0.45280000 0.2557000 -0.19710000 0.01495892 4.856213e-05 FALSE TRUE
ENST00000557199 ENSG00000170581 HEK293_OSMI2_2hA HEK293_TMG_2hB STAT2 protein_coding retained_intron 13.28106 11.33604 11.80173 0.5567184 0.195527 0.0580309 1.2569472 0.7366210 1.295496 0.1026541 0.08012077 0.8061506 0.08972083 0.06446667 0.1097333 0.04526667 0.04702829 4.856213e-05   FALSE
ENST00000557252 ENSG00000170581 HEK293_OSMI2_2hA HEK293_TMG_2hB STAT2 protein_coding processed_transcript 13.28106 11.33604 11.80173 0.5567184 0.195527 0.0580309 1.9973764 1.1098772 1.892002 0.2170210 0.19663273 0.7641784 0.14439167 0.09656667 0.1606333 0.06406667 0.18644283 4.856213e-05   FALSE
ENST00000651805 ENSG00000170581 HEK293_OSMI2_2hA HEK293_TMG_2hB STAT2 protein_coding retained_intron 13.28106 11.33604 11.80173 0.5567184 0.195527 0.0580309 1.2704378 0.4291616 1.423997 0.2651271 0.17407614 1.7072182 0.09289167 0.03613333 0.1203333 0.08420000 0.24323662 4.856213e-05 FALSE TRUE
ENST00000651915 ENSG00000170581 HEK293_OSMI2_2hA HEK293_TMG_2hB STAT2 protein_coding protein_coding 13.28106 11.33604 11.80173 0.5567184 0.195527 0.0580309 0.3015184 0.8548785 0.000000 0.5040582 0.00000000 -6.4344256 0.02485417 0.07953333 0.0000000 -0.07953333 0.16443036 4.856213e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170581 E001 4.8046558 0.0036917566 3.384599e-01 4.823245e-01 12 56341597 56341604 8 - 0.648 0.815 0.681
ENSG00000170581 E002 4.9508727 0.0036675732 2.683758e-01 4.068252e-01 12 56341605 56341607 3 - 0.648 0.835 0.759
ENSG00000170581 E003 8.0078977 0.0021946591 7.663492e-02 1.541085e-01 12 56341608 56341612 5 - 0.791 1.035 0.925
ENSG00000170581 E004 8.4861884 0.0020729115 3.529605e-02 8.221930e-02 12 56341613 56341617 5 - 0.791 1.070 1.054
ENSG00000170581 E005 76.5510182 0.0122675685 1.842557e-07 1.777870e-06 12 56341618 56341799 182 - 1.609 2.016 1.374
ENSG00000170581 E006 167.4185246 0.0112301527 7.428056e-11 1.338046e-09 12 56341800 56342297 498 - 1.935 2.353 1.399
ENSG00000170581 E007 93.8278587 0.0201130032 9.285320e-08 9.483401e-07 12 56342298 56342617 320 - 1.650 2.115 1.565
ENSG00000170581 E008 29.4707627 0.0501660770 6.365329e-02 1.327832e-01 12 56342618 56342622 5 - 1.306 1.577 0.934
ENSG00000170581 E009 32.2364857 0.0509498344 5.080566e-02 1.106119e-01 12 56342623 56342629 7 - 1.335 1.618 0.972
ENSG00000170581 E010 90.7100223 0.0038664623 1.407300e-05 9.031465e-05 12 56342630 56342869 240 - 1.797 2.049 0.844
ENSG00000170581 E011 51.8263210 0.0013604885 3.066071e-05 1.820130e-04 12 56342870 56342935 66 - 1.546 1.808 0.890
ENSG00000170581 E012 132.6441242 0.0057067119 2.314667e-01 3.642295e-01 12 56342936 56343303 368 - 2.061 2.158 0.324
ENSG00000170581 E013 108.0501437 0.0014805575 2.041501e-01 3.313595e-01 12 56343304 56343531 228 - 2.033 2.026 -0.023
ENSG00000170581 E014 105.0933296 0.0003786020 8.934983e-01 9.359090e-01 12 56343825 56344084 260 - 1.992 2.038 0.152
ENSG00000170581 E015 48.6448812 0.0006071058 3.489919e-01 4.932112e-01 12 56344085 56344135 51 - 1.638 1.726 0.299
ENSG00000170581 E016 47.4964656 0.0004990272 5.588953e-01 6.870752e-01 12 56346146 56346203 58 - 1.638 1.708 0.239
ENSG00000170581 E017 62.7610451 0.0003869735 6.286000e-01 7.441225e-01 12 56346442 56346624 183 - 1.760 1.822 0.210
ENSG00000170581 E018 3.7223743 0.0325125195 7.480820e-03 2.246345e-02 12 56346625 56346652 28 - 0.858 0.453 -1.753
ENSG00000170581 E019 2.7593734 0.0108619105 5.457749e-03 1.717560e-02 12 56346653 56346677 25 - 0.765 0.348 -1.975
ENSG00000170581 E020 5.0519139 0.0082344995 6.941015e-01 7.950046e-01 12 56346678 56346818 141 - 0.791 0.772 -0.075
ENSG00000170581 E021 49.7773764 0.0004942150 1.261678e-01 2.288204e-01 12 56346819 56346955 137 - 1.719 1.684 -0.120
ENSG00000170581 E022 50.1363775 0.0101253152 1.147896e-01 2.125223e-01 12 56348529 56348623 95 - 1.739 1.674 -0.221
ENSG00000170581 E023 9.6710612 0.0018514712 9.646681e-03 2.789576e-02 12 56348624 56348751 128 - 1.139 0.907 -0.853
ENSG00000170581 E024 36.8681860 0.0005733297 3.633130e-05 2.115133e-04 12 56348752 56348804 53 - 1.674 1.480 -0.664
ENSG00000170581 E025 10.6340672 0.0017191228 7.210593e-06 4.949726e-05 12 56348805 56348851 47 - 1.253 0.835 -1.535
ENSG00000170581 E026 6.2418886 0.0026720244 3.817445e-02 8.768548e-02 12 56348852 56348912 61 - 0.967 0.749 -0.846
ENSG00000170581 E027 28.2335822 0.0007085346 4.862862e-01 6.240717e-01 12 56348924 56349029 106 - 1.467 1.461 -0.018
ENSG00000170581 E028 15.1441741 0.0012560455 2.855984e-01 4.259525e-01 12 56349030 56349059 30 - 1.128 1.260 0.469
ENSG00000170581 E029 5.2463052 0.0148260569 4.549270e-01 5.955057e-01 12 56349060 56349083 24 - 0.837 0.770 -0.261
ENSG00000170581 E030 25.0399780 0.0007931971 2.004605e-01 3.267885e-01 12 56349163 56349261 99 - 1.435 1.386 -0.167
ENSG00000170581 E031 18.9564011 0.0010091821 1.724520e-06 1.360421e-05 12 56349345 56349425 81 - 1.451 1.113 -1.185
ENSG00000170581 E032 38.3035262 0.0009827525 6.830300e-02 1.405629e-01 12 56349426 56349500 75 - 1.624 1.560 -0.217
ENSG00000170581 E033 25.1778281 0.0097978508 3.155202e-01 4.582861e-01 12 56349501 56349509 9 - 1.435 1.393 -0.146
ENSG00000170581 E034 34.1019464 0.0143412651 1.906101e-01 3.145254e-01 12 56349589 56349636 48 - 1.575 1.511 -0.220
ENSG00000170581 E035 17.3593527 0.0013697603 6.994258e-06 4.818331e-05 12 56349637 56349809 173 - 1.412 1.081 -1.167
ENSG00000170581 E036 12.7153757 0.0013881902 4.200293e-02 9.473010e-02 12 56349860 56350096 237 - 1.209 1.059 -0.539
ENSG00000170581 E037 34.1633873 0.0042310089 3.781858e-01 5.224766e-01 12 56350097 56350190 94 - 1.546 1.527 -0.064
ENSG00000170581 E038 23.5985392 0.0008538356 5.291917e-07 4.657984e-06 12 56350191 56350411 221 - 1.537 1.222 -1.095
ENSG00000170581 E039 24.0107928 0.0087928444 5.191053e-03 1.644888e-02 12 56350412 56350432 21 - 1.487 1.297 -0.656
ENSG00000170581 E040 30.8980725 0.0134125940 8.577009e-02 1.686234e-01 12 56350829 56350888 60 - 1.551 1.446 -0.357
ENSG00000170581 E041 33.2485126 0.0204413706 2.694934e-01 4.080036e-01 12 56351098 56351190 93 - 1.559 1.495 -0.219
ENSG00000170581 E042 2.6152580 0.0075122561 3.467433e-02 8.102411e-02 12 56351203 56351291 89 - 0.711 0.404 -1.432
ENSG00000170581 E043 32.9786673 0.0032991504 9.701881e-02 1.859206e-01 12 56351292 56351450 159 - 1.559 1.489 -0.237
ENSG00000170581 E044 0.2934659 0.0292655120 8.758914e-01   12 56353233 56353285 53 - 0.129 0.116 -0.170
ENSG00000170581 E045 3.3966762 0.0047928045 6.716640e-01 7.778508e-01 12 56354419 56354458 40 - 0.575 0.671 0.418
ENSG00000170581 E046 2.4023299 0.0060934468 5.096686e-01 6.449697e-01 12 56354459 56354465 7 - 0.575 0.498 -0.361
ENSG00000170581 E047 29.2043836 0.0012747099 4.317600e-01 5.742785e-01 12 56354466 56354554 89 - 1.482 1.471 -0.038
ENSG00000170581 E048 26.0694943 0.0131166693 4.024729e-02 9.148612e-02 12 56354555 56354614 60 - 1.501 1.368 -0.461
ENSG00000170581 E049 30.3774232 0.0006844344 1.814281e-02 4.743773e-02 12 56354778 56354863 86 - 1.550 1.443 -0.369
ENSG00000170581 E050 11.3807670 0.0150996608 5.608444e-05 3.121336e-04 12 56354864 56354897 34 - 1.277 0.855 -1.543
ENSG00000170581 E051 12.8496327 0.0501952389 5.878293e-03 1.829273e-02 12 56354898 56354989 92 - 1.309 0.940 -1.330
ENSG00000170581 E052 10.8972238 0.0077944350 1.311821e-02 3.618159e-02 12 56354990 56355071 82 - 1.180 0.954 -0.822
ENSG00000170581 E053 5.2661001 0.0108552121 2.203580e-01 3.508410e-01 12 56355072 56355088 17 - 0.858 0.725 -0.527
ENSG00000170581 E054 14.1289771 0.0274928204 2.754531e-04 1.279798e-03 12 56355089 56355272 184 - 1.357 0.955 -1.439
ENSG00000170581 E055 5.3751228 0.0240147531 1.062832e-02 3.028052e-02 12 56355273 56355275 3 - 0.968 0.639 -1.304
ENSG00000170581 E056 25.2866792 0.0008578929 3.772267e-01 5.215661e-01 12 56355276 56355351 76 - 1.424 1.402 -0.073
ENSG00000170581 E057 31.7463113 0.0006860167 1.300356e-01 2.342162e-01 12 56355443 56355532 90 - 1.537 1.484 -0.182
ENSG00000170581 E058 27.0283377 0.0007694353 4.201563e-02 9.475086e-02 12 56355708 56355791 84 - 1.496 1.402 -0.324
ENSG00000170581 E059 12.7193551 0.0019201586 2.498446e-02 6.184238e-02 12 56355792 56355803 12 - 1.227 1.058 -0.605
ENSG00000170581 E060 26.9555422 0.0008051260 8.264184e-03 2.445257e-02 12 56356132 56356218 87 - 1.515 1.381 -0.463
ENSG00000170581 E061 22.7519074 0.0010776945 5.126426e-03 1.627295e-02 12 56356219 56356281 63 - 1.451 1.289 -0.564
ENSG00000170581 E062 14.5404260 0.0024718256 1.657472e-02 4.400514e-02 12 56356282 56356285 4 - 1.269 1.093 -0.629
ENSG00000170581 E063 25.8250095 0.0007980482 5.080252e-05 2.858106e-04 12 56356441 56356520 80 - 1.537 1.302 -0.813
ENSG00000170581 E064 18.4207842 0.0009831544 1.185271e-03 4.591003e-03 12 56356521 56356578 58 - 1.388 1.171 -0.763
ENSG00000170581 E065 14.3737029 0.0016178941 6.168453e-05 3.396881e-04 12 56360058 56360213 156 - 1.329 1.009 -1.143