ENSG00000170571

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000303221 ENSG00000170571 HEK293_OSMI2_2hA HEK293_TMG_2hB EMB protein_coding protein_coding 10.29286 2.363833 18.49663 0.1081855 1.422011 2.962752 6.8738659 2.20126650 11.9202597 0.10680186 0.5633806 2.431681 0.76755000 0.9311667 0.6474667 -0.2837 1.795927e-09 1.795927e-09 FALSE TRUE
ENST00000505896 ENSG00000170571 HEK293_OSMI2_2hA HEK293_TMG_2hB EMB protein_coding retained_intron 10.29286 2.363833 18.49663 0.1081855 1.422011 2.962752 0.4043519 0.05139481 0.6070153 0.02911150 0.1176384 3.329118 0.05247083 0.0207000 0.0323000 0.0116 6.939535e-01 1.795927e-09 FALSE TRUE
ENST00000506190 ENSG00000170571 HEK293_OSMI2_2hA HEK293_TMG_2hB EMB protein_coding processed_transcript 10.29286 2.363833 18.49663 0.1081855 1.422011 2.962752 1.9250777 0.00000000 3.8120976 0.00000000 2.0853047 8.578221 0.10404167 0.0000000 0.1907000 0.1907 3.808815e-01 1.795927e-09 FALSE FALSE
MSTRG.26151.1 ENSG00000170571 HEK293_OSMI2_2hA HEK293_TMG_2hB EMB protein_coding   10.29286 2.363833 18.49663 0.1081855 1.422011 2.962752 0.9926008 0.11117181 2.0881735 0.03369441 1.3446834 4.114008 0.06980000 0.0481000 0.1258000 0.0777 9.628537e-01 1.795927e-09 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170571 E001 2.022935 0.0082500435 2.335592e-09 3.234436e-08 5 50383170 50383278 109 - 0.049 1.034 6.370
ENSG00000170571 E002 337.465189 0.0068583341 1.514783e-18 8.161862e-17 5 50396192 50398026 1835 - 2.292 2.673 1.267
ENSG00000170571 E003 137.905638 0.0002768254 2.793137e-01 4.190436e-01 5 50398027 50398676 650 - 1.974 2.020 0.155
ENSG00000170571 E004 58.814823 0.0009097677 3.899867e-01 5.340186e-01 5 50398677 50398938 262 - 1.596 1.737 0.480
ENSG00000170571 E005 43.545617 0.0004790315 8.954770e-01 9.372244e-01 5 50398939 50399106 168 - 1.478 1.575 0.334
ENSG00000170571 E006 60.769828 0.0031642950 5.056570e-03 1.608617e-02 5 50399107 50399290 184 - 1.646 1.532 -0.388
ENSG00000170571 E007 33.524615 0.0205434906 2.053460e-01 3.328586e-01 5 50399859 50399913 55 - 1.389 1.335 -0.185
ENSG00000170571 E008 36.653817 0.0096983672 1.788800e-01 2.997358e-01 5 50402286 50402319 34 - 1.425 1.385 -0.139
ENSG00000170571 E009 47.357446 0.0040345604 1.123633e-01 2.089901e-01 5 50403178 50403255 78 - 1.532 1.497 -0.123
ENSG00000170571 E010 91.379943 0.0004568700 7.276305e-04 2.998247e-03 5 50403256 50403454 199 - 1.818 1.723 -0.321
ENSG00000170571 E011 70.634206 0.0005032895 1.503969e-06 1.202458e-05 5 50405725 50405852 128 - 1.721 1.484 -0.807
ENSG00000170571 E012 68.930447 0.0026246368 2.760757e-06 2.083568e-05 5 50410877 50410965 89 - 1.713 1.458 -0.871
ENSG00000170571 E013 48.300986 0.0009640073 7.730552e-06 5.268661e-05 5 50411197 50411221 25 - 1.566 1.276 -1.004
ENSG00000170571 E014 78.572948 0.0003957802 4.167034e-06 3.017015e-05 5 50411222 50411383 162 - 1.764 1.565 -0.675
ENSG00000170571 E015 4.831370 0.0310047054 4.477514e-01 5.891249e-01 5 50411384 50411998 615 - 0.599 0.804 0.854
ENSG00000170571 E016 43.603943 0.0004937924 2.586220e-03 9.023716e-03 5 50428144 50428227 84 - 1.509 1.351 -0.546
ENSG00000170571 E017 0.000000       5 50428459 50428727 269 -      
ENSG00000170571 E018 37.552167 0.0005953008 6.526827e-03 1.999237e-02 5 50441040 50441417 378 - 1.446 1.296 -0.521
ENSG00000170571 E019 0.000000       5 50442952 50442984 33 -      
ENSG00000170571 E020 0.000000       5 50443190 50443248 59 -