ENSG00000170558

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269141 ENSG00000170558 HEK293_OSMI2_2hA HEK293_TMG_2hB CDH2 protein_coding protein_coding 25.67115 14.47387 33.01095 0.6617916 0.2482662 1.188935 13.1292939 11.834992 15.522598 0.7669853 0.1605461 0.391022 0.57446250 0.8165333 0.470300000 -0.3462333 8.024502e-14 3.308839e-102 FALSE TRUE
ENST00000399380 ENSG00000170558 HEK293_OSMI2_2hA HEK293_TMG_2hB CDH2 protein_coding protein_coding 25.67115 14.47387 33.01095 0.6617916 0.2482662 1.188935 0.6641543 2.578865 0.061693 0.2565289 0.0616930 -5.174344 0.04654167 0.1794000 0.001833333 -0.1775667 6.415475e-07 3.308839e-102 FALSE TRUE
ENST00000676445 ENSG00000170558 HEK293_OSMI2_2hA HEK293_TMG_2hB CDH2 protein_coding protein_coding 25.67115 14.47387 33.01095 0.6617916 0.2482662 1.188935 11.6774222 0.000000 17.188721 0.0000000 0.2263234 10.748086 0.37046667 0.0000000 0.520700000 0.5207000 3.308839e-102 3.308839e-102 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170558 E001 0.4720498 0.1542376170 1.000000e+00 1.000000e+00 18 27932879 27933124 246 - 0.172 0.158 -0.149
ENSG00000170558 E002 0.0000000       18 27933834 27933966 133 -      
ENSG00000170558 E003 0.0000000       18 27935230 27935327 98 -      
ENSG00000170558 E004 0.1817044 0.0395043978 2.791886e-01   18 27938043 27938244 202 - 0.000 0.157 12.325
ENSG00000170558 E005 47.4052890 0.0062681142 3.223301e-17 1.472594e-15 18 27950966 27951080 115 - 1.372 1.929 1.894
ENSG00000170558 E006 80.4778617 0.0074816668 4.473481e-24 4.469871e-22 18 27951081 27951211 131 - 1.561 2.169 2.048
ENSG00000170558 E007 49.7691443 0.0069076940 4.237250e-20 2.722056e-18 18 27951212 27951220 9 - 1.354 1.967 2.086
ENSG00000170558 E008 237.9765133 0.0016337669 2.095073e-35 5.236217e-33 18 27951221 27951654 434 - 2.183 2.557 1.245
ENSG00000170558 E009 145.3097996 0.0023237578 8.969735e-10 1.341403e-08 18 27951655 27951763 109 - 2.049 2.282 0.779
ENSG00000170558 E010 203.5103794 0.0002183190 3.381920e-10 5.450865e-09 18 27951764 27951920 157 - 2.230 2.396 0.557
ENSG00000170558 E011 481.0968708 0.0001679389 2.761787e-15 9.873792e-14 18 27951921 27952359 439 - 2.617 2.754 0.458
ENSG00000170558 E012 0.9631146 0.0144384394 8.830823e-01 9.291866e-01 18 27962655 27963356 702 - 0.295 0.272 -0.154
ENSG00000170558 E013 192.9134501 0.0002056399 4.391412e-04 1.925084e-03 18 27963357 27963521 165 - 2.237 2.337 0.334
ENSG00000170558 E014 1.2501240 0.0290879428 9.452568e-01 9.696455e-01 18 27963522 27964175 654 - 0.345 0.363 0.108
ENSG00000170558 E015 0.7384352 0.0171798612 6.950462e-02 1.425366e-01 18 27964176 27964263 88 - 0.345 0.000 -13.229
ENSG00000170558 E016 0.7427016 0.0156101199 6.913079e-02 1.419349e-01 18 27964264 27965298 1035 - 0.345 0.000 -13.230
ENSG00000170558 E017 0.5985731 0.0218661542 6.395296e-01 7.529019e-01 18 27965299 27965982 684 - 0.238 0.157 -0.741
ENSG00000170558 E018 81.7656846 0.0006573967 4.912451e-02 1.075932e-01 18 27982944 27982962 19 - 1.875 1.964 0.299
ENSG00000170558 E019 155.5015926 0.0020350141 9.451991e-01 9.696111e-01 18 27982963 27983083 121 - 2.186 2.193 0.025
ENSG00000170558 E020 237.4803561 0.0017953391 6.062304e-01 7.264251e-01 18 27985000 27985233 234 - 2.374 2.369 -0.017
ENSG00000170558 E021 219.6304633 0.0015156722 3.901403e-03 1.286705e-02 18 27985528 27985761 234 - 2.297 2.390 0.311
ENSG00000170558 E022 166.2124264 0.0018538829 8.702556e-01 9.205462e-01 18 27988524 27988666 143 - 2.210 2.223 0.042
ENSG00000170558 E023 243.7372381 0.0001731558 2.785916e-05 1.669309e-04 18 27990097 27990350 254 - 2.416 2.327 -0.298
ENSG00000170558 E024 222.8559909 0.0002225542 5.058423e-11 9.393269e-10 18 27992655 27992840 186 - 2.399 2.242 -0.523
ENSG00000170558 E025 218.3192141 0.0005910824 1.892026e-13 5.177506e-12 18 27993500 27993637 138 - 2.401 2.208 -0.644
ENSG00000170558 E026 222.7515762 0.0011052018 6.016120e-15 2.046572e-13 18 28002997 28003169 173 - 2.418 2.196 -0.742
ENSG00000170558 E027 160.8120152 0.0018467976 2.209686e-10 3.671125e-09 18 28005849 28005969 121 - 2.276 2.054 -0.743
ENSG00000170558 E028 86.9863888 0.0082471876 1.305049e-05 8.436417e-05 18 28005970 28005993 24 - 2.021 1.761 -0.874
ENSG00000170558 E029 179.2768613 0.0015143932 3.442401e-11 6.561550e-10 18 28009717 28009872 156 - 2.322 2.106 -0.721
ENSG00000170558 E030 195.3152158 0.0004363266 1.868099e-14 5.909264e-13 18 28011846 28011992 147 - 2.358 2.151 -0.692
ENSG00000170558 E031 217.8582182 0.0003895202 1.102422e-15 4.138114e-14 18 28013683 28013909 227 - 2.404 2.200 -0.682
ENSG00000170558 E032 0.1451727 0.0431188569 8.453778e-01   18 28036470 28036585 116 - 0.094 0.000 -10.907
ENSG00000170558 E033 0.0000000       18 28045411 28045596 186 -      
ENSG00000170558 E034 0.1472490 0.0427162305 8.451851e-01   18 28097063 28097254 192 - 0.094 0.000 -10.907
ENSG00000170558 E035 103.8565849 0.0003896100 6.818128e-09 8.671407e-08 18 28147673 28147784 112 - 2.085 1.876 -0.702
ENSG00000170558 E036 0.2924217 0.0290785164 4.085004e-01   18 28159149 28159295 147 - 0.172 0.000 -11.907
ENSG00000170558 E037 59.4485653 0.0026471338 5.340051e-08 5.720745e-07 18 28176963 28177193 231 - 1.868 1.571 -1.005
ENSG00000170558 E038 1.1919493 0.0170460859 1.358166e-01 2.422336e-01 18 28177863 28177946 84 - 0.431 0.157 -1.963