ENSG00000170522

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302274 ENSG00000170522 HEK293_OSMI2_2hA HEK293_TMG_2hB ELOVL6 protein_coding protein_coding 6.313488 5.471391 7.854395 0.1623307 0.4128049 0.5207939 1.8025332 0.49291745 2.7441782 0.18407536 0.3655737 2.4532284 0.23575417 0.08880000 0.34656667 0.2577667 4.924005e-04 1.940876e-13 FALSE TRUE
ENST00000394607 ENSG00000170522 HEK293_OSMI2_2hA HEK293_TMG_2hB ELOVL6 protein_coding protein_coding 6.313488 5.471391 7.854395 0.1623307 0.4128049 0.5207939 1.6628836 1.11727105 2.1580135 0.08019664 0.1655424 0.9435393 0.27971667 0.20540000 0.27830000 0.0729000 4.206546e-01 1.940876e-13 FALSE TRUE
ENST00000503885 ENSG00000170522 HEK293_OSMI2_2hA HEK293_TMG_2hB ELOVL6 protein_coding protein_coding 6.313488 5.471391 7.854395 0.1623307 0.4128049 0.5207939 0.7112491 0.33545324 0.6721056 0.33545324 0.3717007 0.9815047 0.09190417 0.05973333 0.08613333 0.0264000 6.740888e-01 1.940876e-13 FALSE FALSE
ENST00000506625 ENSG00000170522 HEK293_OSMI2_2hA HEK293_TMG_2hB ELOVL6 protein_coding protein_coding 6.313488 5.471391 7.854395 0.1623307 0.4128049 0.5207939 0.6116096 0.02534541 1.3825575 0.02534541 0.4228321 5.3000703 0.08277500 0.00450000 0.17666667 0.1721667 7.306249e-05 1.940876e-13 FALSE FALSE
ENST00000513003 ENSG00000170522 HEK293_OSMI2_2hA HEK293_TMG_2hB ELOVL6 protein_coding processed_transcript 6.313488 5.471391 7.854395 0.1623307 0.4128049 0.5207939 1.4446334 3.50040354 0.8975405 0.18664967 0.1997395 -1.9516029 0.29880000 0.64156667 0.11233333 -0.5292333 1.940876e-13 1.940876e-13   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170522 E001 462.741328 0.0008207508 2.275866e-08 2.625957e-07 4 110045846 110051669 5824 - 2.599 2.681 0.274
ENSG00000170522 E002 23.245882 0.0008172357 3.199150e-03 1.085407e-02 4 110051670 110051693 24 - 1.400 1.164 -0.830
ENSG00000170522 E003 23.972501 0.0009762063 1.677980e-02 4.445057e-02 4 110051694 110051725 32 - 1.407 1.226 -0.630
ENSG00000170522 E004 27.960851 0.0007567152 2.481039e-05 1.506250e-04 4 110051726 110051762 37 - 1.493 1.164 -1.149
ENSG00000170522 E005 28.820944 0.0007795301 1.270581e-08 1.536105e-07 4 110059603 110059644 42 - 1.526 1.049 -1.676
ENSG00000170522 E006 23.002247 0.0008486871 8.230896e-10 1.239423e-08 4 110059645 110059649 5 - 1.443 0.823 -2.241
ENSG00000170522 E007 38.120180 0.0007643797 1.481191e-05 9.465900e-05 4 110059650 110059754 105 - 1.615 1.330 -0.982
ENSG00000170522 E008 0.000000       4 110059755 110060039 285 -      
ENSG00000170522 E009 0.000000       4 110093106 110093134 29 -      
ENSG00000170522 E010 42.154779 0.0005619712 1.792269e-02 4.696916e-02 4 110105497 110105628 132 - 1.629 1.499 -0.443
ENSG00000170522 E011 10.323252 0.0018172350 2.160978e-16 8.919189e-15 4 110197891 110197974 84 - 0.559 1.432 3.313
ENSG00000170522 E012 45.173788 0.0005133000 4.419504e-03 1.431780e-02 4 110198247 110198367 121 - 1.565 1.734 0.574
ENSG00000170522 E013 11.768634 0.0014724461 6.580156e-01 7.672436e-01 4 110198368 110198521 154 - 1.081 1.049 -0.117
ENSG00000170522 E014 13.308699 0.0231615469 1.191415e-02 3.332793e-02 4 110198522 110198653 132 - 0.999 1.298 1.071
ENSG00000170522 E015 1.409128 0.0095286128 8.187516e-01 8.854829e-01 4 110198842 110199099 258 - 0.364 0.329 -0.210
ENSG00000170522 E016 1.477925 0.0235162334 2.301603e-01 3.626496e-01 4 110199100 110199199 100 - 0.287 0.514 1.276