ENSG00000170502

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302174 ENSG00000170502 HEK293_OSMI2_2hA HEK293_TMG_2hB NUDT9 protein_coding protein_coding 22.86608 13.59622 26.84587 0.3384562 2.250856 0.9809715 7.6247564 5.0544919 8.9102280 0.3580259 0.4448114 0.816663041 0.34662083 0.37093333 0.33863333 -0.032300000 8.131884e-01 6.684003e-14 FALSE  
ENST00000512216 ENSG00000170502 HEK293_OSMI2_2hA HEK293_TMG_2hB NUDT9 protein_coding protein_coding 22.86608 13.59622 26.84587 0.3384562 2.250856 0.9809715 10.8567012 6.3634817 12.6453267 0.7078791 0.8915706 0.989591152 0.46019167 0.46603333 0.47210000 0.006066667 9.826096e-01 6.684003e-14 FALSE  
ENST00000515371 ENSG00000170502 HEK293_OSMI2_2hA HEK293_TMG_2hB NUDT9 protein_coding processed_transcript 22.86608 13.59622 26.84587 0.3384562 2.250856 0.9809715 0.9939365 0.0000000 1.6562908 0.0000000 0.1941123 7.380496409 0.04305417 0.00000000 0.06203333 0.062033333 6.684003e-14 6.684003e-14 FALSE  
MSTRG.25141.11 ENSG00000170502 HEK293_OSMI2_2hA HEK293_TMG_2hB NUDT9 protein_coding   22.86608 13.59622 26.84587 0.3384562 2.250856 0.9809715 1.1144933 0.8870232 0.8924925 0.6008121 0.7022358 0.008769608 0.05497500 0.06716667 0.02956667 -0.037600000 8.812287e-01 6.684003e-14 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170502 E001 0.4783925 0.0213825788 0.825156647 0.88986605 4 87422461 87422572 112 + 0.185 0.146 -0.404
ENSG00000170502 E002 1.7338271 0.0078062638 0.726391383 0.81943282 4 87422573 87422588 16 + 0.413 0.477 0.332
ENSG00000170502 E003 2.3594686 0.0063918026 0.990678010 0.99832962 4 87422589 87422593 5 + 0.529 0.531 0.010
ENSG00000170502 E004 2.1777642 0.0068604702 0.735530154 0.82627582 4 87422594 87422596 3 + 0.529 0.477 -0.253
ENSG00000170502 E005 15.6798582 0.0092163695 0.041853919 0.09445589 4 87422597 87422617 21 + 1.302 1.112 -0.674
ENSG00000170502 E006 29.5185091 0.0011198913 0.092906170 0.17968062 4 87422618 87422675 58 + 1.529 1.425 -0.359
ENSG00000170502 E007 26.1733128 0.0020672611 0.037335950 0.08610188 4 87422676 87422680 5 + 1.490 1.346 -0.496
ENSG00000170502 E008 48.3584302 0.0004678810 0.031279685 0.07444432 4 87422681 87422808 128 + 1.734 1.629 -0.355
ENSG00000170502 E009 54.3616421 0.0006176790 0.046535417 0.10300624 4 87422809 87422881 73 + 1.778 1.687 -0.310
ENSG00000170502 E010 70.8263066 0.0003501418 0.012130336 0.03384711 4 87422882 87423012 131 + 1.897 1.797 -0.337
ENSG00000170502 E011 0.1817044 0.0427697161 0.330047612   4 87424643 87424685 43 + 0.000 0.146 10.147
ENSG00000170502 E012 0.3268771 0.0316933542 0.767349929   4 87434226 87434408 183 + 0.102 0.146 0.597
ENSG00000170502 E013 104.6204344 0.0003433706 0.083217652 0.16460726 4 87434981 87435087 107 + 2.045 1.990 -0.182
ENSG00000170502 E014 147.3053840 0.0002431985 0.156704813 0.27070611 4 87435088 87435220 133 + 2.185 2.150 -0.117
ENSG00000170502 E015 0.1472490 0.0435218045 0.709945654   4 87435221 87435224 4 + 0.102 0.000 -9.229
ENSG00000170502 E016 128.6471285 0.0003263996 0.963238649 0.98077853 4 87438277 87438372 96 + 2.107 2.113 0.023
ENSG00000170502 E017 85.3999626 0.0055532213 0.485730185 0.62355666 4 87441829 87441870 42 + 1.914 1.953 0.133
ENSG00000170502 E018 64.7569194 0.0003873488 0.862976006 0.91564109 4 87441871 87441915 45 + 1.815 1.813 -0.007
ENSG00000170502 E019 4.9499249 0.0031808302 0.030427548 0.07280028 4 87445322 87445507 186 + 0.882 0.580 -1.241
ENSG00000170502 E020 115.6114086 0.0003265182 0.898378647 0.93919939 4 87449142 87449253 112 + 2.060 2.070 0.032
ENSG00000170502 E021 185.5907973 0.0002228592 0.019455485 0.05032198 4 87451589 87451735 147 + 2.242 2.306 0.214
ENSG00000170502 E022 159.0860575 0.0008033806 0.098810971 0.18866031 4 87454371 87454455 85 + 2.180 2.234 0.181
ENSG00000170502 E023 0.7479104 0.5087329667 0.637965638 0.75175202 4 87454456 87454456 1 + 0.185 0.329 1.087
ENSG00000170502 E024 299.5777009 0.0016535192 0.008645804 0.02539925 4 87457843 87459455 1613 + 2.444 2.514 0.234
ENSG00000170502 E025 1.0621892 0.0500340810 0.624268633 0.74064847 4 87525353 87525464 112 + 0.254 0.344 0.608