ENSG00000170471

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262879 ENSG00000170471 HEK293_OSMI2_2hA HEK293_TMG_2hB RALGAPB protein_coding protein_coding 12.83024 8.410695 15.35674 0.3337532 0.3360484 0.8677996 2.8564225 0.7045841 5.6502389 0.3527565 0.9087339 2.9856872 0.20476250 0.08533333 0.3667667 0.281433333 2.510046e-01 2.890716e-17 FALSE TRUE
ENST00000397040 ENSG00000170471 HEK293_OSMI2_2hA HEK293_TMG_2hB RALGAPB protein_coding protein_coding 12.83024 8.410695 15.35674 0.3337532 0.3360484 0.8677996 1.6018070 1.9858421 0.0000000 0.6558888 0.0000000 -7.6408538 0.13720417 0.23053333 0.0000000 -0.230533333 4.028478e-10 2.890716e-17 FALSE TRUE
ENST00000397042 ENSG00000170471 HEK293_OSMI2_2hA HEK293_TMG_2hB RALGAPB protein_coding protein_coding 12.83024 8.410695 15.35674 0.3337532 0.3360484 0.8677996 0.7165967 0.2816830 0.5290758 0.2816830 0.5290758 0.8860869 0.05000833 0.03246667 0.0353000 0.002833333 9.390546e-01 2.890716e-17 FALSE TRUE
ENST00000438490 ENSG00000170471 HEK293_OSMI2_2hA HEK293_TMG_2hB RALGAPB protein_coding protein_coding 12.83024 8.410695 15.35674 0.3337532 0.3360484 0.8677996 3.9323021 1.6616350 5.2197661 0.1765728 0.1121448 1.6454865 0.28682500 0.19836667 0.3402667 0.141900000 3.327913e-03 2.890716e-17 FALSE TRUE
ENST00000632792 ENSG00000170471 HEK293_OSMI2_2hA HEK293_TMG_2hB RALGAPB protein_coding protein_coding 12.83024 8.410695 15.35674 0.3337532 0.3360484 0.8677996 1.1034503 2.5928162 0.0000000 0.5116243 0.0000000 -8.0239296 0.11966250 0.31023333 0.0000000 -0.310233333 2.890716e-17 2.890716e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170471 E001 0.4783925 0.0210144606 9.037246e-01 9.427489e-01 20 38472748 38472808 61 + 0.173 0.156 -0.178
ENSG00000170471 E002 0.6299079 0.0225332073 6.075883e-01 7.275138e-01 20 38472809 38472815 7 + 0.239 0.156 -0.763
ENSG00000170471 E003 0.6299079 0.0225332073 6.075883e-01 7.275138e-01 20 38472816 38472817 2 + 0.239 0.156 -0.763
ENSG00000170471 E004 0.6299079 0.0225332073 6.075883e-01 7.275138e-01 20 38472818 38472829 12 + 0.239 0.156 -0.763
ENSG00000170471 E005 2.1745551 0.0066181187 6.863282e-01 7.888729e-01 20 38472830 38472842 13 + 0.471 0.555 0.405
ENSG00000170471 E006 3.0581630 0.0048180212 4.878349e-01 6.254730e-01 20 38472843 38472845 3 + 0.646 0.556 -0.402
ENSG00000170471 E007 13.7877994 0.0012741977 2.096237e-04 1.004975e-03 20 38472846 38472899 54 + 1.270 0.922 -1.261
ENSG00000170471 E008 16.4084315 0.0011048397 1.523248e-05 9.706847e-05 20 38472900 38472927 28 + 1.348 0.965 -1.373
ENSG00000170471 E009 18.4266412 0.0024410621 1.452641e-05 9.294422e-05 20 38472928 38472951 24 + 1.394 1.022 -1.319
ENSG00000170471 E010 29.3350985 0.0038177457 1.811175e-07 1.750175e-06 20 38472952 38473069 118 + 1.591 1.208 -1.324
ENSG00000170471 E011 58.0944076 0.0284169072 2.329505e-04 1.103846e-03 20 38488403 38488618 216 + 1.869 1.540 -1.114
ENSG00000170471 E012 75.9259694 0.0160699409 3.738259e-03 1.240523e-02 20 38492930 38493132 203 + 1.945 1.757 -0.636
ENSG00000170471 E013 59.3008047 0.0007888651 3.296120e-05 1.941184e-04 20 38497353 38497437 85 + 1.836 1.655 -0.614
ENSG00000170471 E014 45.6011285 0.0004754194 6.385205e-05 3.503007e-04 20 38497438 38497479 42 + 1.731 1.535 -0.667
ENSG00000170471 E015 49.2652103 0.0004405865 1.061895e-04 5.504918e-04 20 38497480 38497516 37 + 1.758 1.577 -0.615
ENSG00000170471 E016 85.0376023 0.0089635932 1.494325e-05 9.541789e-05 20 38499447 38499633 187 + 2.010 1.770 -0.809
ENSG00000170471 E017 0.2966881 0.0270712592 3.833153e-01   20 38499634 38500003 370 + 0.173 0.000 -9.854
ENSG00000170471 E018 32.3543724 0.0009293220 8.416813e-05 4.477787e-04 20 38509077 38509084 8 + 1.599 1.363 -0.810
ENSG00000170471 E019 60.4132038 0.0008243814 1.007165e-06 8.348840e-06 20 38509085 38509208 124 + 1.859 1.642 -0.735
ENSG00000170471 E020 34.7785839 0.0007990815 3.859578e-04 1.720517e-03 20 38516192 38516246 55 + 1.617 1.416 -0.687
ENSG00000170471 E021 56.6249090 0.0004301396 3.847142e-03 1.271332e-02 20 38516247 38516370 124 + 1.799 1.683 -0.394
ENSG00000170471 E022 66.5149276 0.0004028723 7.671530e-04 3.140338e-03 20 38517506 38517654 149 + 1.872 1.744 -0.431
ENSG00000170471 E023 86.8358357 0.0070479295 1.081716e-04 5.596709e-04 20 38517784 38518000 217 + 2.008 1.811 -0.660
ENSG00000170471 E024 83.2118427 0.0003124324 4.210729e-07 3.780974e-06 20 38521497 38521698 202 + 1.982 1.798 -0.619
ENSG00000170471 E025 74.2502965 0.0003796636 1.084471e-03 4.250977e-03 20 38524778 38524945 168 + 1.911 1.795 -0.391
ENSG00000170471 E026 68.9711363 0.0008322680 3.533233e-04 1.593184e-03 20 38525404 38525514 111 + 1.890 1.751 -0.469
ENSG00000170471 E027 34.5549846 0.0005844964 4.918307e-03 1.570256e-02 20 38525515 38525518 4 + 1.601 1.451 -0.515
ENSG00000170471 E028 85.2956870 0.0003497600 4.362718e-03 1.415586e-02 20 38525895 38526042 148 + 1.962 1.872 -0.301
ENSG00000170471 E029 54.1677406 0.0004219060 1.181831e-01 2.173247e-01 20 38531167 38531231 65 + 1.754 1.702 -0.179
ENSG00000170471 E030 77.9416415 0.0003626419 9.913228e-02 1.891556e-01 20 38532730 38532859 130 + 1.906 1.862 -0.148
ENSG00000170471 E031 0.1472490 0.0434097675 7.922310e-01   20 38534385 38534393 9 + 0.095 0.000 -8.854
ENSG00000170471 E032 26.3981235 0.0008137517 4.540963e-02 1.009426e-01 20 38535074 38535085 12 + 1.472 1.355 -0.405
ENSG00000170471 E033 76.0307094 0.0012489649 1.907283e-01 3.146643e-01 20 38535086 38535207 122 + 1.891 1.857 -0.115
ENSG00000170471 E034 100.1049897 0.0004799125 4.656268e-01 6.052876e-01 20 38539776 38539958 183 + 1.997 1.995 -0.009
ENSG00000170471 E035 84.2119656 0.0003513810 7.462016e-01 8.340304e-01 20 38541041 38541192 152 + 1.907 1.944 0.124
ENSG00000170471 E036 93.7790997 0.0003171170 1.828388e-01 3.047474e-01 20 38546243 38546430 188 + 1.938 2.011 0.247
ENSG00000170471 E037 0.9672673 0.0152762176 8.368614e-01 8.979863e-01 20 38546431 38548106 1676 + 0.297 0.271 -0.179
ENSG00000170471 E038 74.4861061 0.0035145122 8.695190e-01 9.201281e-01 20 38548689 38548795 107 + 1.862 1.876 0.048
ENSG00000170471 E039 103.1649927 0.0028094195 3.589514e-01 5.032897e-01 20 38551071 38551223 153 + 1.982 2.044 0.206
ENSG00000170471 E040 121.1268288 0.0004823103 3.150198e-02 7.488479e-02 20 38553867 38554076 210 + 2.040 2.136 0.321
ENSG00000170471 E041 107.8207536 0.0029142166 5.467996e-02 1.174338e-01 20 38558295 38558453 159 + 1.985 2.090 0.352
ENSG00000170471 E042 115.3438086 0.0006182183 8.259802e-02 1.636113e-01 20 38562532 38562697 166 + 2.022 2.106 0.281
ENSG00000170471 E043 23.0375475 0.0008402413 1.709463e-01 2.894099e-01 20 38565356 38565358 3 + 1.406 1.329 -0.268
ENSG00000170471 E044 109.2590588 0.0066830130 1.935433e-01 3.182360e-01 20 38565359 38565478 120 + 1.996 2.087 0.303
ENSG00000170471 E045 132.6759935 0.0006572472 8.072344e-06 5.476192e-05 20 38567096 38567232 137 + 2.041 2.209 0.563
ENSG00000170471 E046 24.7946448 0.0018482212 3.969523e-08 4.368366e-07 20 38568467 38569887 1421 + 1.526 1.103 -1.478
ENSG00000170471 E047 104.9723561 0.0012466209 3.908549e-08 4.306770e-07 20 38569888 38569996 109 + 1.911 2.142 0.775
ENSG00000170471 E048 84.4809663 0.0003188017 2.495852e-05 1.513691e-04 20 38570769 38570847 79 + 1.839 2.026 0.627
ENSG00000170471 E049 6.8091544 0.0027174781 6.440391e-01 7.564479e-01 20 38573659 38574149 491 + 0.908 0.874 -0.131
ENSG00000170471 E050 110.8933588 0.0054415313 2.160020e-03 7.720346e-03 20 38574150 38574298 149 + 1.964 2.138 0.582
ENSG00000170471 E051 120.3162689 0.0025408789 2.659908e-06 2.014508e-05 20 38574774 38574940 167 + 1.980 2.190 0.705
ENSG00000170471 E052 69.7839230 0.0003552418 1.740116e-03 6.408625e-03 20 38574941 38575034 94 + 1.775 1.931 0.527
ENSG00000170471 E053 213.9971315 0.0026401329 3.151805e-03 1.071269e-02 20 38575035 38575770 736 + 2.272 2.394 0.407
ENSG00000170471 E054 28.0735627 0.0006661536 7.501775e-01 8.369337e-01 20 38575771 38575872 102 + 1.438 1.483 0.154
ENSG00000170471 E055 633.2096685 0.0064446602 6.240711e-05 3.432780e-04 20 38575873 38578859 2987 + 2.720 2.887 0.556