ENSG00000170469

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302091 ENSG00000170469 HEK293_OSMI2_2hA HEK293_TMG_2hB SPATA24 protein_coding protein_coding 9.807181 18.07157 8.689634 0.4470621 0.7943507 -1.055493 0.8119578 1.433798 0.6007625 0.1844316 0.1904160 -1.2411852 0.09272083 0.07933333 0.06643333 -0.0129000000 8.088654e-01 2.137225e-05 FALSE TRUE
ENST00000450845 ENSG00000170469 HEK293_OSMI2_2hA HEK293_TMG_2hB SPATA24 protein_coding protein_coding 9.807181 18.07157 8.689634 0.4470621 0.7943507 -1.055493 1.6444080 2.037737 2.7604198 0.3425214 0.3367423 0.4360744 0.17945000 0.11210000 0.31813333 0.2060333333 2.137225e-05 2.137225e-05 FALSE TRUE
ENST00000451821 ENSG00000170469 HEK293_OSMI2_2hA HEK293_TMG_2hB SPATA24 protein_coding protein_coding 9.807181 18.07157 8.689634 0.4470621 0.7943507 -1.055493 6.2315652 12.012563 3.9707851 1.4653400 0.2991224 -1.5946196 0.61344583 0.66156667 0.46973333 -0.1918333333 2.502459e-01 2.137225e-05 FALSE TRUE
ENST00000509959 ENSG00000170469 HEK293_OSMI2_2hA HEK293_TMG_2hB SPATA24 protein_coding protein_coding 9.807181 18.07157 8.689634 0.4470621 0.7943507 -1.055493 0.5413083 1.059742 0.5214263 0.4278300 0.1394284 -1.0093219 0.05762917 0.05906667 0.05843333 -0.0006333333 9.415481e-01 2.137225e-05 FALSE TRUE
MSTRG.27015.5 ENSG00000170469 HEK293_OSMI2_2hA HEK293_TMG_2hB SPATA24 protein_coding   9.807181 18.07157 8.689634 0.4470621 0.7943507 -1.055493 0.5117593 1.381690 0.6294956 1.2490093 0.3339728 -1.1218312 0.05062917 0.08006667 0.06700000 -0.0130666667 8.788639e-01 2.137225e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170469 E001 5.588644 0.0031583971 0.8435338985 0.902572458 5 139396563 139396766 204 - 0.749 0.776 0.109
ENSG00000170469 E002 4.777133 0.0036421363 0.9733231524 0.987342650 5 139396767 139396777 11 - 0.707 0.711 0.016
ENSG00000170469 E003 12.010972 0.0063817471 0.4319704681 0.574453588 5 139396778 139396853 76 - 1.123 1.038 -0.308
ENSG00000170469 E004 16.939615 0.0317463679 0.0291834527 0.070356030 5 139396854 139396929 76 - 1.380 1.121 -0.911
ENSG00000170469 E005 7.716977 0.0162550190 0.1456393466 0.255719542 5 139396930 139396955 26 - 1.030 0.843 -0.704
ENSG00000170469 E006 24.059683 0.0008598713 0.0006202956 0.002607752 5 139397041 139397143 103 - 1.515 1.274 -0.835
ENSG00000170469 E007 5.763063 0.0117955990 0.4495621200 0.590764778 5 139397381 139397426 46 - 0.854 0.745 -0.429
ENSG00000170469 E008 4.554744 0.1117581921 0.6122647610 0.731232291 5 139401460 139401500 41 - 0.749 0.663 -0.353
ENSG00000170469 E009 5.402875 0.0740763566 0.5294068305 0.662185625 5 139401501 139401524 24 - 0.822 0.718 -0.416
ENSG00000170469 E010 63.911337 0.0067235591 0.0304297414 0.072803799 5 139401525 139401754 230 - 1.653 1.787 0.452
ENSG00000170469 E011 71.009588 0.0006981440 0.1795429958 0.300571577 5 139401755 139401816 62 - 1.758 1.819 0.205
ENSG00000170469 E012 46.296679 0.0007173057 0.0638395470 0.133086225 5 139401817 139401825 9 - 1.541 1.647 0.362
ENSG00000170469 E013 106.287751 0.0003004296 0.1871450547 0.310157546 5 139401915 139402045 131 - 1.939 1.985 0.153
ENSG00000170469 E014 73.717399 0.0005007688 0.7826811402 0.860487323 5 139402628 139402693 66 - 1.823 1.810 -0.044
ENSG00000170469 E015 72.441068 0.0011137383 0.1968846660 0.322339642 5 139403944 139404089 146 - 1.849 1.790 -0.198