ENSG00000170456

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000389082 ENSG00000170456 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND5B protein_coding protein_coding 3.540407 1.872848 5.281773 0.05014034 0.308411 1.490835 1.5933249 0.7611795 3.1745884 0.02241954 0.1713633 2.0459683 0.4217958 0.4064333 0.60166667 0.19523333 4.770968e-03 1.046112e-05 FALSE TRUE
ENST00000546299 ENSG00000170456 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND5B protein_coding protein_coding 3.540407 1.872848 5.281773 0.05014034 0.308411 1.490835 1.1671832 0.9413106 0.6973312 0.03117643 0.2725647 -0.4275305 0.4017042 0.5039667 0.12950000 -0.37446667 9.258602e-03 1.046112e-05 FALSE TRUE
MSTRG.7072.4 ENSG00000170456 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND5B protein_coding   3.540407 1.872848 5.281773 0.05014034 0.308411 1.490835 0.2467157 0.0000000 0.3185558 0.00000000 0.1566881 5.0380665 0.0504000 0.0000000 0.05743333 0.05743333 2.930163e-02 1.046112e-05 FALSE TRUE
MSTRG.7072.6 ENSG00000170456 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND5B protein_coding   3.540407 1.872848 5.281773 0.05014034 0.308411 1.490835 0.2653772 0.0000000 0.7634379 0.00000000 0.1079275 6.2732135 0.0555250 0.0000000 0.14733333 0.14733333 1.046112e-05 1.046112e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170456 E001 88.5750219 0.0043181325 4.365152e-12 9.631551e-11 12 31382226 31383465 1240 - 1.776 2.120 1.154
ENSG00000170456 E002 200.5153429 0.0002095780 3.914090e-03 1.290238e-02 12 31383466 31387392 3927 - 2.248 2.190 -0.194
ENSG00000170456 E003 2.5079522 0.0242412727 8.165678e-01 8.839537e-01 12 31387393 31387406 14 - 0.498 0.466 -0.158
ENSG00000170456 E004 10.3293292 0.0053890570 2.001820e-01 3.264769e-01 12 31387407 31387532 126 - 1.018 0.870 -0.555
ENSG00000170456 E005 7.1602611 0.0022968883 1.323152e-01 2.373270e-01 12 31387533 31387564 32 - 0.891 0.685 -0.818
ENSG00000170456 E006 22.5466029 0.0009055369 8.224123e-01 8.880375e-01 12 31387565 31387786 222 - 1.305 1.306 0.003
ENSG00000170456 E007 19.2976934 0.0009228139 1.130703e-01 2.100122e-01 12 31389324 31389498 175 - 1.272 1.140 -0.466
ENSG00000170456 E008 14.5690244 0.0016309855 2.558603e-01 3.927973e-01 12 31392267 31392393 127 - 1.153 1.051 -0.369
ENSG00000170456 E009 13.5239618 0.0013765915 5.853696e-02 1.241263e-01 12 31392614 31392696 83 - 1.138 0.939 -0.728
ENSG00000170456 E010 24.0963515 0.0050442846 8.739921e-04 3.523326e-03 12 31398175 31398362 188 - 1.389 1.075 -1.110
ENSG00000170456 E011 22.7032988 0.0008592831 2.693806e-02 6.586394e-02 12 31399654 31399772 119 - 1.342 1.160 -0.642
ENSG00000170456 E012 26.1222515 0.0013714285 2.998151e-02 7.192396e-02 12 31402498 31402643 146 - 1.397 1.231 -0.581
ENSG00000170456 E013 20.4132595 0.0010891519 1.070835e-05 7.068751e-05 12 31409263 31409384 122 - 1.336 0.870 -1.689
ENSG00000170456 E014 17.7404490 0.0011930893 1.859932e-03 6.789182e-03 12 31413436 31413564 129 - 1.260 0.939 -1.161
ENSG00000170456 E015 14.1640775 0.0011881204 8.385412e-04 3.396675e-03 12 31415367 31415448 82 - 1.182 0.787 -1.472
ENSG00000170456 E016 15.3245888 0.0012266767 1.375548e-02 3.766727e-02 12 31423597 31423675 79 - 1.196 0.939 -0.937
ENSG00000170456 E017 11.1909674 0.0016322154 1.788457e-02 4.689000e-02 12 31424535 31424568 34 - 1.076 0.787 -1.090
ENSG00000170456 E018 15.5798871 0.0020284367 1.631485e-03 6.061819e-03 12 31424569 31424687 119 - 1.219 0.869 -1.279
ENSG00000170456 E019 15.4841365 0.0011331648 9.855958e-06 6.561645e-05 12 31426293 31426424 132 - 1.236 0.685 -2.076
ENSG00000170456 E020 0.0000000       12 31426425 31426751 327 -      
ENSG00000170456 E021 1.7296730 0.0111137789 8.921237e-03 2.608343e-02 12 31432375 31433154 780 - 0.220 0.686 2.541
ENSG00000170456 E022 14.8231172 0.0011493539 1.341514e-03 5.114833e-03 12 31433155 31433248 94 - 1.196 0.830 -1.352
ENSG00000170456 E023 16.8740114 0.0011178663 4.118767e-05 2.367123e-04 12 31442775 31442925 151 - 1.260 0.787 -1.746
ENSG00000170456 E024 25.2597182 0.0013728839 8.004786e-03 2.379058e-02 12 31447538 31447769 232 - 1.395 1.179 -0.757
ENSG00000170456 E025 6.4681487 0.0542970964 3.101107e-06 2.312428e-05 12 31451702 31451939 238 - 0.498 1.254 2.977
ENSG00000170456 E026 72.5857625 0.0003770616 7.430044e-06 5.083605e-05 12 31451940 31452476 537 - 1.738 1.954 0.728
ENSG00000170456 E027 21.7266796 0.0010688377 2.768568e-02 6.738920e-02 12 31460194 31460238 45 - 1.240 1.435 0.681
ENSG00000170456 E028 35.2924621 0.0006512192 1.402573e-02 3.828293e-02 12 31460239 31460381 143 - 1.446 1.623 0.605
ENSG00000170456 E029 55.7780239 0.0131842809 3.872824e-02 8.868118e-02 12 31479589 31480119 531 - 1.635 1.805 0.575
ENSG00000170456 E030 9.0915945 0.0019564051 1.339204e-01 2.395938e-01 12 31480120 31480128 9 - 0.882 1.075 0.720
ENSG00000170456 E031 19.1421102 0.0111933937 2.624824e-02 6.445168e-02 12 31480129 31480255 127 - 1.163 1.395 0.814
ENSG00000170456 E032 15.9069988 0.0332535667 2.226577e-02 5.622446e-02 12 31495810 31495919 110 - 1.070 1.361 1.032
ENSG00000170456 E033 5.1234377 0.0811776707 6.593234e-01 7.681625e-01 12 31499606 31499671 66 - 0.710 0.787 0.312
ENSG00000170456 E034 0.1472490 0.0439820186 1.000000e+00   12 31500393 31500652 260 - 0.066 0.000 -7.173
ENSG00000170456 E035 0.0000000       12 31516351 31516413 63 -      
ENSG00000170456 E036 0.2934659 0.0292025384 3.412827e-01   12 31540920 31541031 112 - 0.066 0.215 1.952
ENSG00000170456 E037 0.3289534 0.0297176207 3.404193e-01   12 31590386 31590705 320 - 0.066 0.215 1.955
ENSG00000170456 E038 10.8827938 0.0099022616 8.168290e-02 1.621903e-01 12 31590706 31591136 431 - 0.943 1.161 0.796