ENSG00000170412

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392627 ENSG00000170412 HEK293_OSMI2_2hA HEK293_TMG_2hB GPRC5C protein_coding protein_coding 7.756918 14.59124 4.155054 0.1961114 0.03463251 -1.809684 4.0987972 7.0862849 2.4558917 0.2618488 0.24820224 -1.524954 0.55863333 0.48590000 0.5903667 0.10446667 0.397042565 0.005739709 FALSE TRUE
ENST00000582873 ENSG00000170412 HEK293_OSMI2_2hA HEK293_TMG_2hB GPRC5C protein_coding processed_transcript 7.756918 14.59124 4.155054 0.1961114 0.03463251 -1.809684 1.8315222 4.7568418 0.7181756 0.4561910 0.05280538 -2.710676 0.19243333 0.32530000 0.1727333 -0.15256667 0.005739709 0.005739709 FALSE FALSE
ENST00000652232 ENSG00000170412 HEK293_OSMI2_2hA HEK293_TMG_2hB GPRC5C protein_coding protein_coding 7.756918 14.59124 4.155054 0.1961114 0.03463251 -1.809684 0.5424297 0.9171931 0.1933225 0.1011238 0.11528084 -2.189100 0.07378333 0.06306667 0.0467000 -0.01636667 0.726971884 0.005739709 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170412 E001 0.0000000       17 74424851 74424932 82 +      
ENSG00000170412 E002 4.2394940 0.0045239523 0.40202788 0.54572860 17 74431384 74431527 144 + 0.724 0.595 -0.547
ENSG00000170412 E003 9.7110760 0.0196575319 0.98692531 0.99587901 17 74431528 74431835 308 + 0.922 0.928 0.022
ENSG00000170412 E004 10.8141146 0.0024185097 0.92258105 0.95516981 17 74431836 74432087 252 + 0.982 0.976 -0.022
ENSG00000170412 E005 13.1358794 0.0064727913 0.12171145 0.22237741 17 74432088 74432115 28 + 1.179 1.020 -0.574
ENSG00000170412 E006 20.8572569 0.0009054438 0.12137457 0.22188774 17 74432116 74432132 17 + 1.340 1.214 -0.441
ENSG00000170412 E007 23.4965700 0.0008780547 0.14445264 0.25408387 17 74432133 74432141 9 + 1.375 1.262 -0.394
ENSG00000170412 E008 3.9899361 0.0052712199 0.15779468 0.27218925 17 74432142 74432523 382 + 0.771 0.555 -0.921
ENSG00000170412 E009 0.1515154 0.0453286049 0.12399267   17 74433697 74433757 61 + 0.208 0.000 -10.981
ENSG00000170412 E010 48.7285218 0.0007120523 0.04016232 0.09133900 17 74439745 74439895 151 + 1.678 1.565 -0.382
ENSG00000170412 E011 62.9775177 0.0004405447 0.05555386 0.11892776 17 74439896 74440046 151 + 1.773 1.682 -0.306
ENSG00000170412 E012 126.9799891 0.0013839505 0.16744868 0.28488589 17 74440047 74440682 636 + 1.954 2.012 0.196
ENSG00000170412 E013 65.1651215 0.0004192482 0.75884042 0.84334051 17 74440683 74440827 145 + 1.700 1.721 0.073
ENSG00000170412 E014 6.2289204 0.0067587412 0.16621680 0.28327883 17 74443077 74443084 8 + 0.922 0.739 -0.717
ENSG00000170412 E015 8.2111317 0.0573966291 0.38015697 0.52443873 17 74443085 74443134 50 + 0.981 0.845 -0.516
ENSG00000170412 E016 6.2696934 0.0041162578 0.08075529 0.16072582 17 74443135 74443817 683 + 0.953 0.725 -0.887
ENSG00000170412 E017 66.0978019 0.0088273552 0.31012517 0.45249756 17 74443818 74443912 95 + 1.666 1.738 0.243
ENSG00000170412 E018 3.8225235 0.0045786508 0.13858116 0.24613078 17 74445204 74446848 1645 + 0.348 0.632 1.421
ENSG00000170412 E019 93.7415556 0.0003283074 0.16073264 0.27608065 17 74446849 74446998 150 + 1.820 1.886 0.224
ENSG00000170412 E020 110.5762045 0.0041155176 0.04378380 0.09799408 17 74446999 74447429 431 + 1.858 1.963 0.351
ENSG00000170412 E021 1.4726265 0.0093281871 0.13377894 0.23940846 17 74448823 74448915 93 + 0.538 0.270 -1.507
ENSG00000170412 E022 0.0000000       17 74448916 74449017 102 +      
ENSG00000170412 E023 13.9761146 0.0013079897 0.31848529 0.46145791 17 74449335 74450580 1246 + 0.982 1.099 0.430
ENSG00000170412 E024 5.3110446 0.0037844909 0.83770707 0.89855051 17 74450887 74451653 767 + 0.724 0.697 -0.111