ENSG00000170390

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296550 ENSG00000170390 HEK293_OSMI2_2hA HEK293_TMG_2hB DCLK2 protein_coding protein_coding 2.054318 2.235533 1.619553 0.03963633 0.005101443 -0.4625816 0.6334465 0.5213420 0.8734159 0.1082763 0.18107296 0.733452012 0.32467083 0.23206667 0.5399 0.30783333 0.09775702 0.04310455 FALSE TRUE
ENST00000411937 ENSG00000170390 HEK293_OSMI2_2hA HEK293_TMG_2hB DCLK2 protein_coding nonsense_mediated_decay 2.054318 2.235533 1.619553 0.03963633 0.005101443 -0.4625816 0.3143008 0.4717467 0.4674520 0.2449134 0.06381484 -0.012919064 0.14450000 0.21220000 0.2886 0.07640000 0.77863086 0.04310455 TRUE TRUE
ENST00000506325 ENSG00000170390 HEK293_OSMI2_2hA HEK293_TMG_2hB DCLK2 protein_coding protein_coding 2.054318 2.235533 1.619553 0.03963633 0.005101443 -0.4625816 0.1585480 0.1755842 0.1745843 0.1755842 0.17458432 -0.007793863 0.08760833 0.07713333 0.1072 0.03006667 1.00000000 0.04310455 FALSE TRUE
ENST00000634233 ENSG00000170390 HEK293_OSMI2_2hA HEK293_TMG_2hB DCLK2 protein_coding nonsense_mediated_decay 2.054318 2.235533 1.619553 0.03963633 0.005101443 -0.4625816 0.2048234 0.0000000 0.0000000 0.0000000 0.00000000 0.000000000 0.07869583 0.00000000 0.0000 0.00000000   0.04310455   FALSE
MSTRG.25591.6 ENSG00000170390 HEK293_OSMI2_2hA HEK293_TMG_2hB DCLK2 protein_coding   2.054318 2.235533 1.619553 0.03963633 0.005101443 -0.4625816 0.7366162 1.0668599 0.1041008 0.1718479 0.10410078 -3.238450109 0.36185000 0.47860000 0.0643 -0.41430000 0.04310455 0.04310455 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170390 E001 10.587396 0.0019698915 1.760031e-02 4.627025e-02 4 150078445 150078988 544 + 1.188 0.948 -0.873
ENSG00000170390 E002 4.014831 0.0040728801 5.104326e-01 6.456433e-01 4 150078989 150079025 37 + 0.754 0.656 -0.406
ENSG00000170390 E003 3.026838 0.0112114498 9.434878e-01 9.685493e-01 4 150079026 150079027 2 + 0.615 0.600 -0.065
ENSG00000170390 E004 12.120992 0.0015418440 1.380509e-01 2.453662e-01 4 150079028 150079290 263 + 1.188 1.043 -0.521
ENSG00000170390 E005 10.145926 0.0018317359 1.344636e-01 2.403647e-01 4 150079291 150079448 158 + 1.130 0.974 -0.568
ENSG00000170390 E006 21.286803 0.0616453803 6.101115e-01 7.294699e-01 4 150102478 150102812 335 + 1.388 1.301 -0.305
ENSG00000170390 E007 0.000000       4 150175443 150175636 194 +      
ENSG00000170390 E008 12.171039 0.0016229628 6.476473e-01 7.592810e-01 4 150193138 150193240 103 + 1.142 1.093 -0.174
ENSG00000170390 E009 12.829034 0.0014732810 3.298959e-01 4.734574e-01 4 150198002 150198103 102 + 1.188 1.094 -0.339
ENSG00000170390 E010 0.000000       4 150199028 150199078 51 +      
ENSG00000170390 E011 12.621933 0.0016263363 1.047934e-01 1.977921e-01 4 150203795 150203889 95 + 1.210 1.054 -0.558
ENSG00000170390 E012 4.522343 0.0041557653 9.959199e-02 1.898569e-01 4 150220703 150220705 3 + 0.860 0.629 -0.936
ENSG00000170390 E013 11.783337 0.0282596866 6.206073e-01 7.377310e-01 4 150220706 150220778 73 + 1.129 1.058 -0.258
ENSG00000170390 E014 16.237499 0.0396638219 4.192044e-01 5.624482e-01 4 150221677 150221785 109 + 1.278 1.172 -0.373
ENSG00000170390 E015 16.198640 0.0012534421 6.204205e-01 7.375876e-01 4 150224501 150224558 58 + 1.250 1.202 -0.166
ENSG00000170390 E016 21.237512 0.0009959262 9.071886e-01 9.450563e-01 4 150232337 150232456 120 + 1.328 1.330 0.008
ENSG00000170390 E017 22.944880 0.0009434407 8.387225e-02 1.656123e-01 4 150232682 150232828 147 + 1.286 1.406 0.416
ENSG00000170390 E018 20.083851 0.0185780114 5.153125e-01 6.499974e-01 4 150239742 150239875 134 + 1.358 1.286 -0.250
ENSG00000170390 E019 14.175601 0.0167004418 6.043602e-01 7.249498e-01 4 150240399 150240471 73 + 1.209 1.146 -0.224
ENSG00000170390 E020 6.730306 0.0026197004 3.479403e-01 4.921552e-01 4 150240472 150240476 5 + 0.944 0.826 -0.450
ENSG00000170390 E021 15.232998 0.0014127812 6.027978e-01 7.237048e-01 4 150247603 150247699 97 + 1.230 1.180 -0.178
ENSG00000170390 E022 16.707107 0.0011374707 9.721632e-01 9.866150e-01 4 150248305 150248385 81 + 1.240 1.231 -0.031
ENSG00000170390 E023 16.365476 0.0012031437 1.327422e-01 2.379172e-01 4 150249568 150249684 117 + 1.142 1.264 0.435
ENSG00000170390 E024 7.348264 0.0026467154 1.277943e-02 3.539614e-02 4 150253474 150253556 83 + 0.690 0.998 1.201
ENSG00000170390 E025 1.223168 0.0130699621 9.411050e-01 9.669678e-01 4 150254426 150254438 13 + 0.336 0.320 -0.105
ENSG00000170390 E026 79.928041 0.0003664184 1.189316e-06 9.718861e-06 4 150256020 150257438 1419 + 1.774 1.951 0.594