ENSG00000170348

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000303575 ENSG00000170348 HEK293_OSMI2_2hA HEK293_TMG_2hB TMED10 protein_coding protein_coding 257.7718 156.7616 376.3644 13.85866 6.037352 1.263504 72.93881 41.79666 114.0293 8.062517 4.438616 1.4477268 0.2721125 0.2640333 0.3035000 0.03946667 6.845959e-01 1.306796e-30 FALSE TRUE
ENST00000555085 ENSG00000170348 HEK293_OSMI2_2hA HEK293_TMG_2hB TMED10 protein_coding retained_intron 257.7718 156.7616 376.3644 13.85866 6.037352 1.263504 92.72916 46.89991 144.7495 3.649190 9.895292 1.6256939 0.3477083 0.3023333 0.3839333 0.08160000 2.201426e-01 1.306796e-30 FALSE FALSE
ENST00000557670 ENSG00000170348 HEK293_OSMI2_2hA HEK293_TMG_2hB TMED10 protein_coding processed_transcript 257.7718 156.7616 376.3644 13.85866 6.037352 1.263504 88.83638 65.46913 112.3661 5.808675 2.228805 0.7792278 0.3664417 0.4176333 0.2985333 -0.11910000 1.306796e-30 1.306796e-30   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170348 E001 4310.5326978 8.429649e-03 1.098535e-01 2.053462e-01 14 75131469 75133937 2469 - 3.658 3.569 -0.297
ENSG00000170348 E002 956.6408972 1.272970e-03 1.644133e-06 1.302538e-05 14 75133938 75134355 418 - 3.024 2.884 -0.463
ENSG00000170348 E003 954.2419072 1.119332e-04 5.860489e-27 7.527132e-25 14 75134356 75134439 84 - 2.935 3.034 0.329
ENSG00000170348 E004 969.4563810 9.041818e-05 3.235482e-37 9.372361e-35 14 75134440 75134499 60 - 2.932 3.052 0.398
ENSG00000170348 E005 3132.7397298 7.513415e-04 1.806441e-09 2.551061e-08 14 75134500 75135006 507 - 3.475 3.507 0.105
ENSG00000170348 E006 3.9889977 4.042559e-03 8.899341e-01 9.336583e-01 14 75135663 75135759 97 - 0.704 0.658 -0.195
ENSG00000170348 E007 1450.3337904 1.024561e-03 8.311111e-01 8.941231e-01 14 75135760 75135886 127 - 3.169 3.131 -0.125
ENSG00000170348 E008 2.5873478 5.785489e-03 4.173859e-02 9.425849e-02 14 75139074 75139171 98 - 0.661 0.276 -2.014
ENSG00000170348 E009 1.5562634 2.599429e-01 5.861587e-01 7.097723e-01 14 75147555 75147663 109 - 0.464 0.276 -1.105
ENSG00000170348 E010 1166.6237668 9.805603e-04 2.000880e-01 3.263630e-01 14 75147664 75147737 74 - 3.084 3.020 -0.213
ENSG00000170348 E011 6.1126647 7.537895e-02 9.543446e-01 9.753974e-01 14 75147738 75147781 44 - 0.859 0.848 -0.042
ENSG00000170348 E012 0.2214452 5.869589e-02 2.403135e-01   14 75147833 75147897 65 - 0.000 0.160 9.202
ENSG00000170348 E013 1378.9815493 5.754155e-04 3.146476e-04 1.439450e-03 14 75152032 75152143 112 - 3.166 3.074 -0.305
ENSG00000170348 E014 1.9112651 7.681123e-03 2.429467e-01 3.776484e-01 14 75175921 75176354 434 - 0.386 0.563 0.892
ENSG00000170348 E015 1539.3902897 3.947241e-03 4.780232e-03 1.531827e-02 14 75176355 75176612 258 - 3.226 3.093 -0.443