ENSG00000170322

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000446488 ENSG00000170322 HEK293_OSMI2_2hA HEK293_TMG_2hB NFRKB protein_coding protein_coding 30.46924 33.2298 26.73792 1.876103 0.3751325 -0.3134848 2.806649 5.5669818 0.000000 2.9783927 0.0000000 -9.1233407 0.09000833 0.178533333 0.00000000 -0.17853333 0.1781216052 0.0004142677 FALSE  
ENST00000524794 ENSG00000170322 HEK293_OSMI2_2hA HEK293_TMG_2hB NFRKB protein_coding protein_coding 30.46924 33.2298 26.73792 1.876103 0.3751325 -0.3134848 1.688341 0.1517697 2.410926 0.1164686 0.6963694 3.9035457 0.05850417 0.004266667 0.08976667 0.08550000 0.0004142677 0.0004142677 FALSE  
ENST00000531318 ENSG00000170322 HEK293_OSMI2_2hA HEK293_TMG_2hB NFRKB protein_coding protein_coding 30.46924 33.2298 26.73792 1.876103 0.3751325 -0.3134848 1.782486 0.5900442 1.789278 0.0924454 0.4001574 1.5842774 0.06109167 0.017600000 0.06656667 0.04896667 0.0014153265 0.0004142677 FALSE  
ENST00000682444 ENSG00000170322 HEK293_OSMI2_2hA HEK293_TMG_2hB NFRKB protein_coding protein_coding 30.46924 33.2298 26.73792 1.876103 0.3751325 -0.3134848 13.100260 14.0747763 11.894826 4.5775328 1.0178935 -0.2425901 0.42601667 0.411566667 0.44520000 0.03363333 0.9095153518 0.0004142677 FALSE  
MSTRG.6571.1 ENSG00000170322 HEK293_OSMI2_2hA HEK293_TMG_2hB NFRKB protein_coding   30.46924 33.2298 26.73792 1.876103 0.3751325 -0.3134848 2.813361 2.9001362 1.876067 0.5282826 1.1527274 -0.6257057 0.08868750 0.086233333 0.07136667 -0.01486667 0.8004211577 0.0004142677 FALSE  
MSTRG.6571.2 ENSG00000170322 HEK293_OSMI2_2hA HEK293_TMG_2hB NFRKB protein_coding   30.46924 33.2298 26.73792 1.876103 0.3751325 -0.3134848 2.698014 4.8600487 1.845258 0.8591545 1.3056734 -1.3923160 0.08558333 0.149433333 0.06840000 -0.08103333 0.5702289126 0.0004142677 FALSE  
MSTRG.6571.5 ENSG00000170322 HEK293_OSMI2_2hA HEK293_TMG_2hB NFRKB protein_coding   30.46924 33.2298 26.73792 1.876103 0.3751325 -0.3134848 2.139099 3.4877115 1.548028 0.2450005 0.4560351 -1.1666902 0.07032500 0.104866667 0.05753333 -0.04733333 0.1436612611 0.0004142677 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170322 E001 13.604743 0.0028788236 1.018905e-01 1.933747e-01 11 129863606 129863635 30 - 1.016 1.195 0.644
ENSG00000170322 E002 58.168153 0.0092486473 4.874862e-06 3.480283e-05 11 129863636 129863828 193 - 1.514 1.853 1.151
ENSG00000170322 E003 624.604705 0.0087122149 1.746026e-10 2.955763e-09 11 129863829 129864273 445 - 2.549 2.872 1.074
ENSG00000170322 E004 269.884837 0.0028872571 1.338227e-21 1.021035e-19 11 129864274 129864375 102 - 2.150 2.515 1.219
ENSG00000170322 E005 159.107683 0.0053106270 3.239910e-10 5.243555e-09 11 129864376 129864386 11 - 1.957 2.278 1.077
ENSG00000170322 E006 225.785368 0.0038532756 2.582334e-10 4.240772e-09 11 129864387 129864441 55 - 2.147 2.420 0.911
ENSG00000170322 E007 198.127116 0.0055341848 3.045346e-06 2.275237e-05 11 129864442 129864469 28 - 2.122 2.354 0.775
ENSG00000170322 E008 423.296252 0.0013586657 1.820579e-11 3.630942e-10 11 129864470 129864703 234 - 2.481 2.670 0.632
ENSG00000170322 E009 357.498020 0.0017607536 3.763297e-06 2.755770e-05 11 129864704 129864850 147 - 2.435 2.585 0.499
ENSG00000170322 E010 332.449993 0.0017183495 4.010808e-08 4.410468e-07 11 129864966 129865101 136 - 2.384 2.561 0.591
ENSG00000170322 E011 279.030117 0.0016067197 4.536222e-06 3.261132e-05 11 129865877 129865983 107 - 2.322 2.478 0.517
ENSG00000170322 E012 543.274219 0.0002553184 2.297314e-05 1.404295e-04 11 129869494 129869912 419 - 2.658 2.749 0.303
ENSG00000170322 E013 210.098383 0.0002280502 2.833033e-01 4.233827e-01 11 129869913 129869975 63 - 2.277 2.323 0.153
ENSG00000170322 E014 285.399337 0.0002723138 8.423179e-02 1.661907e-01 11 129869976 129870092 117 - 2.451 2.431 -0.067
ENSG00000170322 E015 241.716708 0.0037497596 3.140374e-01 4.567039e-01 11 129870093 129870179 87 - 2.378 2.360 -0.061
ENSG00000170322 E016 231.213839 0.0002614999 1.597333e-01 2.747677e-01 11 129870180 129870261 82 - 2.357 2.341 -0.055
ENSG00000170322 E017 3.564529 0.0652767529 8.136808e-03 2.413147e-02 11 129872589 129872883 295 - 0.883 0.419 -2.030
ENSG00000170322 E018 318.175219 0.0023516827 8.779228e-01 9.255984e-01 11 129872884 129873092 209 - 2.470 2.494 0.081
ENSG00000170322 E019 102.846680 0.0065168581 6.548586e-01 7.649115e-01 11 129873093 129873096 4 - 1.999 1.995 -0.013
ENSG00000170322 E020 346.797374 0.0004731304 3.628630e-01 5.072708e-01 11 129873745 129874015 271 - 2.522 2.521 -0.003
ENSG00000170322 E021 278.364731 0.0009178103 1.450373e-02 3.937248e-02 11 129874113 129874333 221 - 2.453 2.409 -0.146
ENSG00000170322 E022 163.006558 0.0022394173 1.557921e-01 2.694857e-01 11 129874501 129874580 80 - 2.217 2.185 -0.108
ENSG00000170322 E023 194.639550 0.0012930693 7.257412e-07 6.212530e-06 11 129874793 129874916 124 - 2.354 2.222 -0.440
ENSG00000170322 E024 184.262273 0.0002259504 3.328428e-08 3.715737e-07 11 129875357 129875463 107 - 2.329 2.200 -0.431
ENSG00000170322 E025 223.620344 0.0001771091 1.151275e-03 4.475706e-03 11 129876721 129876895 175 - 2.371 2.310 -0.204
ENSG00000170322 E026 158.823525 0.0002261890 2.104893e-02 5.369641e-02 11 129877325 129877382 58 - 2.215 2.166 -0.163
ENSG00000170322 E027 104.034197 0.0002908412 1.298540e-02 3.587640e-02 11 129877383 129877385 3 - 2.048 1.978 -0.234
ENSG00000170322 E028 106.936427 0.0002669814 4.251865e-03 1.384716e-02 11 129878309 129878310 2 - 2.066 1.984 -0.274
ENSG00000170322 E029 147.264857 0.0002149661 6.060180e-04 2.555270e-03 11 129878311 129878351 41 - 2.204 2.120 -0.281
ENSG00000170322 E030 95.410816 0.0003504981 3.832778e-03 1.267271e-02 11 129878352 129878355 4 - 2.021 1.932 -0.298
ENSG00000170322 E031 167.419970 0.0002017808 1.277804e-04 6.490326e-04 11 129878464 129878543 80 - 2.261 2.172 -0.298
ENSG00000170322 E032 141.794594 0.0007233096 2.197944e-03 7.835643e-03 11 129881443 129881508 66 - 2.184 2.103 -0.271
ENSG00000170322 E033 158.477345 0.0082409645 2.014272e-01 3.279713e-01 11 129881727 129881853 127 - 2.211 2.167 -0.149
ENSG00000170322 E034 142.271268 0.0112969988 3.186923e-02 7.559858e-02 11 129882086 129882194 109 - 2.205 2.095 -0.366
ENSG00000170322 E035 173.418305 0.0037628392 1.751519e-05 1.100491e-04 11 129882451 129882631 181 - 2.313 2.161 -0.508
ENSG00000170322 E036 140.326914 0.0002342514 7.850900e-12 1.662384e-10 11 129883122 129883206 85 - 2.241 2.052 -0.633
ENSG00000170322 E037 132.700465 0.0003337090 4.832571e-10 7.583170e-09 11 129884070 129884143 74 - 2.211 2.033 -0.596
ENSG00000170322 E038 0.000000       11 129884744 129884744 1 -      
ENSG00000170322 E039 144.827647 0.0008080093 6.172980e-07 5.362985e-06 11 129884745 129884846 102 - 2.229 2.087 -0.474
ENSG00000170322 E040 47.046837 0.0004787324 6.233071e-08 6.590226e-07 11 129884847 129884882 36 - 1.808 1.549 -0.879
ENSG00000170322 E041 151.111344 0.0028141088 2.727045e-04 1.268664e-03 11 129885435 129885510 76 - 2.236 2.116 -0.401
ENSG00000170322 E042 154.216409 0.0069336719 1.833399e-02 4.786363e-02 11 129885511 129885609 99 - 2.229 2.136 -0.310
ENSG00000170322 E043 190.673946 0.0077588252 1.136623e-03 4.426193e-03 11 129886317 129886444 128 - 2.347 2.210 -0.458
ENSG00000170322 E044 2.023050 0.0166915804 2.923225e-01 4.332829e-01 11 129888313 129888487 175 - 0.337 0.536 1.055
ENSG00000170322 E045 135.315632 0.0088916059 3.382886e-04 1.533713e-03 11 129888594 129888654 61 - 2.217 2.045 -0.575
ENSG00000170322 E046 185.961998 0.0069048070 8.014822e-05 4.285709e-04 11 129888655 129888795 141 - 2.352 2.187 -0.551
ENSG00000170322 E047 0.000000       11 129892710 129892714 5 -      
ENSG00000170322 E048 179.638729 0.0107502173 5.025191e-04 2.169323e-03 11 129892715 129892870 156 - 2.340 2.170 -0.570
ENSG00000170322 E049 6.939191 0.0329771384 1.058904e-05 6.997806e-05 11 129892871 129892888 18 - 1.167 0.538 -2.481
ENSG00000170322 E050 8.546282 0.0026570211 7.681025e-08 7.975964e-07 11 129892889 129893009 121 - 1.241 0.655 -2.221
ENSG00000170322 E051 7.536186 0.0330489849 1.419264e-02 3.866096e-02 11 129893062 129893101 40 - 1.092 0.770 -1.217
ENSG00000170322 E052 6.582509 0.0437155257 1.689894e-02 4.471180e-02 11 129893102 129893152 51 - 1.048 0.706 -1.321
ENSG00000170322 E053 4.289544 0.3300651851 3.119948e-01 4.545162e-01 11 129893291 129893292 2 - 0.834 0.597 -0.977
ENSG00000170322 E054 4.952850 0.3119509656 2.278019e-01 3.597924e-01 11 129893293 129893296 4 - 0.903 0.630 -1.097
ENSG00000170322 E055 30.681623 0.0478708752 2.861701e-01 4.265700e-01 11 129893297 129893385 89 - 1.557 1.430 -0.434
ENSG00000170322 E056 16.164192 0.0012195087 9.376979e-14 2.677782e-12 11 129893964 129894358 395 - 1.504 0.875 -2.247
ENSG00000170322 E057 92.831677 0.0113920618 1.171833e-03 4.545460e-03 11 129894359 129894438 80 - 2.058 1.879 -0.603
ENSG00000170322 E058 1.748589 0.0721572770 3.866503e-01 5.308299e-01 11 129894439 129894441 3 - 0.525 0.370 -0.803
ENSG00000170322 E059 7.299836 0.0022720966 3.783970e-02 8.704426e-02 11 129894887 129895067 181 - 1.032 0.807 -0.850
ENSG00000170322 E060 63.646009 0.0063731223 3.843929e-05 2.225138e-04 11 129895496 129895604 109 - 1.917 1.698 -0.741