ENSG00000170315

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302182 ENSG00000170315 HEK293_OSMI2_2hA HEK293_TMG_2hB UBB protein_coding protein_coding 2524.45 4094.437 1906.863 327.1713 18.00721 -1.10246 1758.9446 2671.196 1441.3590 226.89360 10.764757 -0.8900513 0.7102167 0.6518333 0.7559000 0.1040667 4.436871e-28 4.436871e-28 FALSE TRUE
ENST00000535788 ENSG00000170315 HEK293_OSMI2_2hA HEK293_TMG_2hB UBB protein_coding protein_coding 2524.45 4094.437 1906.863 327.1713 18.00721 -1.10246 618.0543 1108.920 397.3264 87.43684 5.277623 -1.4807359 0.2366083 0.2709333 0.2083333 -0.0626000 3.191447e-15 4.436871e-28 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170315 E001 4.353170 5.614891e-03 9.578211e-01 9.775583e-01 17 16380787 16380797 11 + 0.693 0.706 0.053
ENSG00000170315 E002 16.010648 1.889512e-03 4.758831e-04 2.067861e-03 17 16380798 16380820 23 + 1.382 1.086 -1.047
ENSG00000170315 E003 46.502347 1.408479e-03 6.348358e-05 3.484910e-04 17 16380821 16380930 110 + 1.778 1.562 -0.734
ENSG00000170315 E004 65.685491 4.837537e-03 8.737732e-05 4.627207e-04 17 16380931 16381029 99 + 1.925 1.710 -0.723
ENSG00000170315 E005 37.388071 7.794072e-03 1.011842e-02 2.905324e-02 17 16381030 16381036 7 + 1.665 1.488 -0.604
ENSG00000170315 E006 226.716560 2.174369e-04 6.400749e-01 7.533894e-01 17 16381037 16381090 54 + 2.314 2.305 -0.029
ENSG00000170315 E007 240.349667 1.183120e-03 3.258592e-01 4.692993e-01 17 16381091 16381094 4 + 2.309 2.339 0.100
ENSG00000170315 E008 10412.013897 3.904107e-04 4.716606e-01 6.107420e-01 17 16381095 16381184 90 + 3.962 3.966 0.012
ENSG00000170315 E009 4.049498 1.882898e-01 5.916250e-01 7.143641e-01 17 16381290 16381340 51 + 0.735 0.617 -0.500
ENSG00000170315 E010 130.153979 4.620426e-03 1.544025e-01 2.676195e-01 17 16381341 16381462 122 + 2.115 2.048 -0.224
ENSG00000170315 E011 33.885755 1.894515e-03 2.777973e-05 1.665070e-04 17 16381463 16381464 2 + 1.670 1.407 -0.899
ENSG00000170315 E012 54.625830 7.512861e-03 6.121411e-05 3.374507e-04 17 16381465 16381515 51 + 1.868 1.611 -0.871
ENSG00000170315 E013 35.454141 2.947988e-02 3.782795e-07 3.426928e-06 17 16381516 16381679 164 + 1.823 1.297 -1.800
ENSG00000170315 E014 11714.005524 1.657945e-04 9.375140e-04 3.745607e-03 17 16381902 16381955 54 + 4.001 4.022 0.071
ENSG00000170315 E015 12330.270312 1.894484e-05 4.697545e-03 1.508903e-02 17 16381956 16381988 33 + 4.032 4.046 0.046
ENSG00000170315 E016 23607.292286 3.767362e-04 7.339563e-02 1.489527e-01 17 16381989 16382130 142 + 4.334 4.314 -0.065
ENSG00000170315 E017 9131.205195 2.241927e-05 3.302597e-20 2.158217e-18 17 16382131 16382183 53 + 3.939 3.901 -0.127
ENSG00000170315 E018 4959.944956 2.209551e-04 7.131582e-20 4.455992e-18 17 16382184 16382216 33 + 3.703 3.621 -0.270
ENSG00000170315 E019 9187.517978 5.953371e-04 9.908836e-01 9.984411e-01 17 16382217 16382238 22 + 3.912 3.910 -0.010
ENSG00000170315 E020 11454.781146 4.196249e-04 3.737775e-03 1.240442e-02 17 16382239 16382358 120 + 4.028 3.998 -0.101
ENSG00000170315 E021 14864.231493 2.414544e-05 6.408546e-03 1.968352e-02 17 16382359 16382411 53 + 4.114 4.126 0.040
ENSG00000170315 E022 17099.099725 3.217245e-04 1.599024e-01 2.749811e-01 17 16382412 16382466 55 + 4.173 4.183 0.034
ENSG00000170315 E023 13894.075749 1.271456e-04 4.834855e-21 3.502672e-19 17 16382467 16382745 279 + 4.050 4.105 0.184