ENSG00000170291

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000396628 ENSG00000170291 HEK293_OSMI2_2hA HEK293_TMG_2hB ELP5 protein_coding protein_coding 227.4667 444.0214 119.1389 10.07176 0.3497834 -1.897897 48.93536 82.09295 32.824776 2.713224 0.8804125 -1.322209 0.23092917 0.1848333 0.2754667 0.09063333 3.893884e-10 3.893884e-10 FALSE  
ENST00000573657 ENSG00000170291 HEK293_OSMI2_2hA HEK293_TMG_2hB ELP5 protein_coding protein_coding 227.4667 444.0214 119.1389 10.07176 0.3497834 -1.897897 18.97158 53.53197 2.293421 8.023332 2.2934212 -4.538820 0.07367917 0.1199000 0.0193000 -0.10060000 6.676138e-02 3.893884e-10 FALSE  
ENST00000574255 ENSG00000170291 HEK293_OSMI2_2hA HEK293_TMG_2hB ELP5 protein_coding protein_coding 227.4667 444.0214 119.1389 10.07176 0.3497834 -1.897897 135.99840 270.60158 64.517833 1.013792 3.2046740 -2.068230 0.57523333 0.6100000 0.5415000 -0.06850000 2.592057e-01 3.893884e-10 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170291 E001 4.47732 3.210200e-02 2.407133e-02 5.995979e-02 17 7251416 7251573 158 + 0.211 0.694 2.658
ENSG00000170291 E002 22.76619 4.553448e-03 8.898144e-01 9.335741e-01 17 7251739 7251800 62 + 1.267 1.264 -0.011
ENSG00000170291 E003 125.97765 3.927876e-03 2.785395e-01 4.182156e-01 17 7251801 7252033 233 + 1.934 2.001 0.223
ENSG00000170291 E004 83.51960 1.681009e-03 9.191350e-01 9.529320e-01 17 7252034 7252055 22 + 1.798 1.814 0.054
ENSG00000170291 E005 78.72298 3.425465e-03 8.382038e-01 8.988394e-01 17 7252056 7252057 2 + 1.767 1.790 0.078
ENSG00000170291 E006 104.39670 3.453245e-03 2.891826e-01 4.298463e-01 17 7252058 7252082 25 + 1.851 1.919 0.228
ENSG00000170291 E007 32.86058 6.424060e-04 3.666472e-01 5.109924e-01 17 7252215 7252231 17 + 1.464 1.408 -0.192
ENSG00000170291 E008 44.35155 5.797266e-04 2.720496e-01 4.108852e-01 17 7252232 7252236 5 + 1.592 1.533 -0.203
ENSG00000170291 E009 223.29118 2.093613e-04 9.720315e-01 9.865184e-01 17 7252237 7252285 49 + 2.229 2.241 0.040
ENSG00000170291 E010 464.90164 3.627797e-04 1.710699e-01 2.895777e-01 17 7252286 7252337 52 + 2.520 2.562 0.140
ENSG00000170291 E011 432.89522 2.282040e-04 7.496955e-02 1.514848e-01 17 7252338 7252345 8 + 2.482 2.533 0.172
ENSG00000170291 E012 510.89067 3.730710e-04 9.698441e-03 2.801849e-02 17 7252346 7252375 30 + 2.539 2.608 0.227
ENSG00000170291 E013 533.12431 3.798744e-04 8.116532e-04 3.300675e-03 17 7252376 7252425 50 + 2.544 2.628 0.281
ENSG00000170291 E014 995.37549 5.086315e-04 7.056530e-08 7.377695e-07 17 7252426 7252524 99 + 2.794 2.903 0.362
ENSG00000170291 E015 958.34564 5.396875e-04 1.611650e-05 1.021350e-04 17 7252525 7252554 30 + 2.793 2.884 0.303
ENSG00000170291 E016 1271.06031 5.196519e-04 6.028829e-03 1.868696e-02 17 7252555 7252596 42 + 2.944 3.001 0.189
ENSG00000170291 E017 25.85780 1.444753e-02 4.867013e-01 6.244225e-01 17 7252623 7252769 147 + 1.371 1.318 -0.184
ENSG00000170291 E018 1891.97137 2.400065e-04 8.867649e-03 2.595078e-02 17 7252770 7252830 61 + 3.128 3.172 0.144
ENSG00000170291 E019 2412.31498 1.653562e-04 2.000939e-04 9.641424e-04 17 7252918 7252998 81 + 3.228 3.278 0.167
ENSG00000170291 E020 2970.83993 1.358366e-04 1.881401e-07 1.811936e-06 17 7254583 7254766 184 + 3.312 3.371 0.198
ENSG00000170291 E021 1297.00748 1.730954e-03 5.133548e-03 1.629174e-02 17 7254767 7254803 37 + 2.938 3.016 0.258
ENSG00000170291 E022 820.72880 4.905927e-03 2.934225e-09 3.989380e-08 17 7254804 7254913 110 + 2.598 2.839 0.805
ENSG00000170291 E023 704.97629 9.332308e-05 2.349285e-58 2.270740e-55 17 7256857 7257038 182 + 2.919 2.683 -0.785
ENSG00000170291 E024 596.75521 1.200082e-04 7.015691e-54 5.469554e-51 17 7258588 7258683 96 + 2.855 2.608 -0.822
ENSG00000170291 E025 74.07234 3.990148e-04 9.022351e-12 1.893704e-10 17 7258684 7258720 37 + 1.990 1.690 -1.011
ENSG00000170291 E026 98.95470 3.439633e-03 3.046699e-07 2.815139e-06 17 7258721 7258825 105 + 2.073 1.836 -0.798
ENSG00000170291 E027 566.17277 1.206834e-04 8.307568e-36 2.132580e-33 17 7258826 7258926 101 + 2.802 2.596 -0.687
ENSG00000170291 E028 348.05777 2.063545e-03 1.785471e-04 8.717390e-04 17 7258927 7259570 644 + 2.517 2.412 -0.349
ENSG00000170291 E029 292.79165 1.510659e-04 9.984366e-15 3.284438e-13 17 7259571 7259574 4 + 2.495 2.318 -0.589
ENSG00000170291 E030 740.57372 2.152956e-03 2.504876e-11 4.891170e-10 17 7259575 7259940 366 + 2.889 2.725 -0.545