ENSG00000170264

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307507 ENSG00000170264 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM161A protein_coding nonsense_mediated_decay 3.203364 0.9727552 4.77607 0.08114472 0.1256481 2.283937 0.2339794 0.02275418 0.5941626 0.01225383 0.11058923 4.2051858 0.05274583 0.02446667 0.12430000 0.09983333 0.04776603 0.04776603 FALSE  
ENST00000404929 ENSG00000170264 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM161A protein_coding protein_coding 3.203364 0.9727552 4.77607 0.08114472 0.1256481 2.283937 0.8904180 0.45624674 1.6711025 0.19030472 0.14888254 1.8502421 0.27615417 0.47183333 0.35190000 -0.11993333 0.81704539 0.04776603 FALSE  
ENST00000405894 ENSG00000170264 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM161A protein_coding protein_coding 3.203364 0.9727552 4.77607 0.08114472 0.1256481 2.283937 0.9038634 0.24614235 1.1095794 0.12352119 0.18309976 2.1279391 0.30470833 0.26270000 0.23063333 -0.03206667 1.00000000 0.04776603 FALSE  
ENST00000418113 ENSG00000170264 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM161A protein_coding nonsense_mediated_decay 3.203364 0.9727552 4.77607 0.08114472 0.1256481 2.283937 0.1684988 0.03990273 0.2866978 0.02026782 0.03531048 2.5718039 0.05100833 0.04350000 0.05973333 0.01623333 0.91787064 0.04776603 TRUE  
ENST00000456262 ENSG00000170264 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM161A protein_coding nonsense_mediated_decay 3.203364 0.9727552 4.77607 0.08114472 0.1256481 2.283937 0.1801758 0.08629049 0.1469911 0.08629049 0.08559174 0.7052177 0.05487917 0.07960000 0.03176667 -0.04783333 1.00000000 0.04776603 FALSE  
ENST00000478494 ENSG00000170264 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM161A protein_coding retained_intron 3.203364 0.9727552 4.77607 0.08114472 0.1256481 2.283937 0.4315717 0.06194210 0.4136571 0.06194210 0.22033837 2.5579888 0.14357500 0.05713333 0.08480000 0.02766667 0.85463004 0.04776603    
ENST00000496369 ENSG00000170264 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM161A protein_coding retained_intron 3.203364 0.9727552 4.77607 0.08114472 0.1256481 2.283937 0.3948567 0.05947665 0.5538792 0.04591855 0.11137652 3.0207861 0.11692500 0.06070000 0.11693333 0.05623333 0.50994864 0.04776603 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170264 E001 0.000000       2 61824848 61824853 6 -      
ENSG00000170264 E002 0.000000       2 61824854 61824855 2 -      
ENSG00000170264 E003 79.080592 0.0003910869 8.540049e-14 2.451344e-12 2 61824856 61826599 1744 - 1.748 2.017 0.905
ENSG00000170264 E004 21.511665 0.0009368110 2.611963e-02 6.418544e-02 2 61827104 61827258 155 - 1.315 1.095 -0.780
ENSG00000170264 E005 3.199257 0.0136757040 4.909856e-01 6.282980e-01 2 61835515 61836009 495 - 0.526 0.641 0.517
ENSG00000170264 E006 11.738811 0.0182096406 3.352369e-01 4.790106e-01 2 61836010 61836056 47 - 1.061 0.924 -0.510
ENSG00000170264 E007 14.396390 0.0013379046 9.542074e-01 9.752994e-01 2 61836057 61836109 53 - 1.118 1.118 0.001
ENSG00000170264 E008 2.596710 0.1210445412 9.575846e-01 9.774065e-01 2 61836110 61836484 375 - 0.506 0.479 -0.133
ENSG00000170264 E009 2.374322 0.0064989557 1.510098e-01 2.630340e-01 2 61836583 61836872 290 - 0.526 0.224 -1.809
ENSG00000170264 E010 12.261475 0.0014836760 3.493294e-01 4.935374e-01 2 61838538 61838705 168 - 1.074 0.958 -0.425
ENSG00000170264 E011 86.933215 0.0030848017 2.872140e-04 1.327993e-03 2 61839421 61840525 1105 - 1.896 1.718 -0.601
ENSG00000170264 E012 11.257576 0.0016694545 1.129821e-01 2.098917e-01 2 61840526 61840581 56 - 1.056 0.849 -0.776
ENSG00000170264 E013 25.466267 0.0015876177 1.506352e-01 2.625408e-01 2 61842122 61842360 239 - 1.365 1.235 -0.455
ENSG00000170264 E014 1.850989 0.0075454205 8.545683e-01 9.100368e-01 2 61846759 61846996 238 - 0.410 0.371 -0.223
ENSG00000170264 E015 17.590674 0.0019739262 8.337917e-01 8.959030e-01 2 61853859 61854143 285 - 1.185 1.199 0.051