ENSG00000170248

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307296 ENSG00000170248 HEK293_OSMI2_2hA HEK293_TMG_2hB PDCD6IP protein_coding protein_coding 84.14497 35.06054 124.7424 2.04001 2.025687 1.830736 14.056771 9.958039 21.446586 0.9356763 1.0140750 1.106039 0.19155833 0.2893667 0.17176667 -0.117600000 7.492107e-02 1.434309e-45 FALSE TRUE
ENST00000435909 ENSG00000170248 HEK293_OSMI2_2hA HEK293_TMG_2hB PDCD6IP protein_coding nonsense_mediated_decay 84.14497 35.06054 124.7424 2.04001 2.025687 1.830736 5.889809 0.000000 12.620044 0.0000000 0.5137871 10.302644 0.05040417 0.0000000 0.10126667 0.101266667 1.434309e-45 1.434309e-45 TRUE FALSE
ENST00000457054 ENSG00000170248 HEK293_OSMI2_2hA HEK293_TMG_2hB PDCD6IP protein_coding protein_coding 84.14497 35.06054 124.7424 2.04001 2.025687 1.830736 5.554718 2.877785 9.476179 0.4264916 0.5322578 1.715864 0.06332083 0.0814000 0.07613333 -0.005266667 9.026588e-01 1.434309e-45 FALSE TRUE
ENST00000465122 ENSG00000170248 HEK293_OSMI2_2hA HEK293_TMG_2hB PDCD6IP protein_coding retained_intron 84.14497 35.06054 124.7424 2.04001 2.025687 1.830736 15.873802 9.163129 22.212533 0.5403595 1.0991794 1.276537 0.21335833 0.2614333 0.17786667 -0.083566667 8.868117e-06 1.434309e-45 FALSE FALSE
MSTRG.22697.9 ENSG00000170248 HEK293_OSMI2_2hA HEK293_TMG_2hB PDCD6IP protein_coding   84.14497 35.06054 124.7424 2.04001 2.025687 1.830736 29.019208 10.752668 40.557233 1.6567221 0.5443318 1.914279 0.33572500 0.3032667 0.32523333 0.021966667 8.184147e-01 1.434309e-45 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170248 E001 0.0000000       3 33794271 33794432 162 +      
ENSG00000170248 E002 0.0000000       3 33794433 33795685 1253 +      
ENSG00000170248 E003 0.0000000       3 33795686 33797023 1338 +      
ENSG00000170248 E004 0.0000000       3 33797024 33798570 1547 +      
ENSG00000170248 E005 0.0000000       3 33798571 33798574 4 +      
ENSG00000170248 E006 14.7369570 0.0021993330 2.629724e-02 6.454453e-02 3 33798575 33798610 36 + 1.219 1.019 -0.722
ENSG00000170248 E007 21.3787019 0.0054803557 2.179869e-02 5.525492e-02 3 33798611 33798620 10 + 1.366 1.182 -0.647
ENSG00000170248 E008 22.7094666 0.0102050729 3.491953e-02 8.149954e-02 3 33798621 33798622 2 + 1.388 1.212 -0.615
ENSG00000170248 E009 28.8470649 0.0083782269 1.453354e-03 5.484722e-03 3 33798623 33798629 7 + 1.507 1.252 -0.884
ENSG00000170248 E010 385.5544597 0.0068079595 4.280227e-05 2.450665e-04 3 33798630 33798937 308 + 2.598 2.446 -0.508
ENSG00000170248 E011 0.9026481 0.7296885837 7.781322e-01 8.572422e-01 3 33798940 33799538 599 + 0.260 0.299 0.274
ENSG00000170248 E012 0.0000000       3 33811063 33811096 34 +      
ENSG00000170248 E013 0.8921407 0.0132198256 8.496607e-02 1.673518e-01 3 33811097 33811191 95 + 0.345 0.000 -10.656
ENSG00000170248 E014 177.8343158 0.0020175811 1.402870e-03 5.315922e-03 3 33812072 33812126 55 + 2.246 2.157 -0.300
ENSG00000170248 E015 0.8995276 0.2456444727 5.983104e-01 7.199361e-01 3 33813277 33813558 282 + 0.304 0.181 -0.974
ENSG00000170248 E016 221.1668002 0.0030839996 8.872417e-04 3.569447e-03 3 33813559 33813628 70 + 2.343 2.245 -0.327
ENSG00000170248 E017 156.2856917 0.0031286838 1.861004e-03 6.792309e-03 3 33821955 33821972 18 + 2.195 2.092 -0.344
ENSG00000170248 E018 217.7598705 0.0002224685 1.457028e-06 1.168725e-05 3 33821973 33822034 62 + 2.338 2.234 -0.348
ENSG00000170248 E019 218.9541694 0.0001982985 2.083265e-05 1.286906e-04 3 33822035 33822082 48 + 2.336 2.248 -0.292
ENSG00000170248 E020 0.8126314 0.0140314105 6.497448e-01 7.608946e-01 3 33824409 33824493 85 + 0.257 0.183 -0.624
ENSG00000170248 E021 223.6867077 0.0027604241 3.237880e-02 7.658679e-02 3 33825187 33825240 54 + 2.335 2.285 -0.168
ENSG00000170248 E022 295.6553550 0.0021687643 1.187237e-02 3.322577e-02 3 33825241 33825340 100 + 2.456 2.404 -0.173
ENSG00000170248 E023 253.9382368 0.0124574050 4.129499e-01 5.565112e-01 3 33826480 33826580 101 + 2.380 2.365 -0.049
ENSG00000170248 E024 19.4508809 0.0013621192 3.685271e-05 2.142329e-04 3 33826581 33826877 297 + 1.366 0.996 -1.319
ENSG00000170248 E025 9.1482698 0.0029322476 4.073496e-04 1.802938e-03 3 33827580 33827596 17 + 1.076 0.618 -1.795
ENSG00000170248 E026 9.2966767 0.0020323679 1.075511e-03 4.219786e-03 3 33827597 33827621 25 + 1.076 0.669 -1.573
ENSG00000170248 E027 17.1514624 0.0010587728 7.695021e-04 3.148188e-03 3 33827622 33827739 118 + 1.301 0.996 -1.092
ENSG00000170248 E028 23.6352158 0.0050400891 4.031604e-06 2.929767e-05 3 33827740 33827959 220 + 1.454 1.040 -1.462
ENSG00000170248 E029 37.6831111 0.0006259877 7.092766e-08 7.411082e-07 3 33828481 33828837 357 + 1.638 1.287 -1.210
ENSG00000170248 E030 17.6315111 0.0010324617 1.324213e-01 2.374421e-01 3 33828838 33828852 15 + 1.274 1.165 -0.385
ENSG00000170248 E031 314.2225023 0.0001640508 5.302683e-02 1.145301e-01 3 33828853 33828969 117 + 2.472 2.457 -0.050
ENSG00000170248 E032 1.0759214 0.0118967130 3.609975e-01 5.053714e-01 3 33835254 33835318 65 + 0.345 0.183 -1.211
ENSG00000170248 E033 525.9236070 0.0003638272 1.785864e-04 8.718856e-04 3 33836044 33836266 223 + 2.703 2.661 -0.142
ENSG00000170248 E034 395.8828305 0.0011500380 7.375428e-02 1.495348e-01 3 33838204 33838327 124 + 2.571 2.554 -0.056
ENSG00000170248 E035 498.9069667 0.0005812207 3.836203e-03 1.268162e-02 3 33841897 33842074 178 + 2.676 2.645 -0.104
ENSG00000170248 E036 0.7416694 0.0192360363 6.495368e-01 7.607921e-01 3 33844091 33844111 21 + 0.257 0.183 -0.627
ENSG00000170248 E037 423.6985347 0.0008465294 1.740225e-01 2.934117e-01 3 33844112 33844223 112 + 2.597 2.594 -0.012
ENSG00000170248 E038 228.4490194 0.0001897706 2.640331e-02 6.475284e-02 3 33845419 33845420 2 + 2.338 2.308 -0.100
ENSG00000170248 E039 401.7093938 0.0002053489 4.806329e-01 6.188757e-01 3 33845421 33845588 168 + 2.568 2.582 0.046
ENSG00000170248 E040 204.1108944 0.0045285356 2.104469e-01 3.390642e-01 3 33852488 33852607 120 + 2.253 2.332 0.263
ENSG00000170248 E041 265.6387635 0.0006749866 8.466433e-04 3.425759e-03 3 33852608 33852736 129 + 2.354 2.467 0.378
ENSG00000170248 E042 448.2316560 0.0001711033 1.257821e-03 4.835734e-03 3 33853879 33854013 135 + 2.592 2.679 0.289
ENSG00000170248 E043 3.3902212 0.0047465114 2.854571e-02 6.910662e-02 3 33854618 33855165 548 + 0.480 0.830 1.511
ENSG00000170248 E044 446.6826410 0.0001524748 1.056178e-03 4.153910e-03 3 33855166 33855260 95 + 2.590 2.678 0.291
ENSG00000170248 E045 2.2366350 0.1003180256 6.103324e-01 7.296558e-01 3 33855261 33855329 69 + 0.509 0.412 -0.493
ENSG00000170248 E046 2.0252177 0.0073472370 8.993175e-01 9.397609e-01 3 33863896 33864005 110 + 0.450 0.491 0.204
ENSG00000170248 E047 501.3515367 0.0009741569 8.188127e-08 8.457642e-07 3 33864006 33864129 124 + 2.619 2.765 0.483
ENSG00000170248 E048 529.0585354 0.0062724909 5.625649e-05 3.129392e-04 3 33865243 33865430 188 + 2.622 2.817 0.647
ENSG00000170248 E049 1745.7078591 0.0094497221 2.465261e-02 6.116642e-02 3 33866351 33869707 3357 + 3.169 3.291 0.407