ENSG00000170144

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392524 ENSG00000170144 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPA3 protein_coding protein_coding 208.5182 171.8541 280.0469 10.83013 9.541955 0.704452 130.22985 124.38218 167.39175 7.577764 6.577913 0.4284188 0.6319458 0.7239667 0.5986 -0.12536667 0.001332291 4.096774e-28 FALSE TRUE
ENST00000676874 ENSG00000170144 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPA3 protein_coding protein_coding 208.5182 171.8541 280.0469 10.83013 9.541955 0.704452 52.23153 33.55635 76.35946 1.975344 2.323680 1.1859802 0.2452417 0.1965667 0.2728 0.07623333 0.013726229 4.096774e-28 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170144 E001 0.6632174 0.0271196013 1.996254e-01 3.257598e-01 2 177212563 177212572 10 + 0.109 0.325 1.971
ENSG00000170144 E002 1.5562885 0.0605959361 8.612058e-01 9.144570e-01 2 177212573 177212598 26 + 0.433 0.395 -0.207
ENSG00000170144 E003 2.6989148 0.0070490993 1.206871e-01 2.209469e-01 2 177212599 177212646 48 + 0.433 0.674 1.124
ENSG00000170144 E004 2.3991062 0.0089880145 1.129377e-01 2.098298e-01 2 177212647 177212662 16 + 0.384 0.639 1.236
ENSG00000170144 E005 2.9988252 0.0101031597 5.485529e-01 6.784065e-01 2 177212663 177212681 19 + 0.552 0.639 0.388
ENSG00000170144 E006 3.0730214 0.0263463074 3.013513e-01 4.431395e-01 2 177212682 177212693 12 + 0.516 0.675 0.714
ENSG00000170144 E007 4.6659302 0.0372543666 7.015676e-01 8.006859e-01 2 177212694 177212723 30 + 0.722 0.768 0.187
ENSG00000170144 E008 4.3693453 0.0041440152 5.491037e-01 6.788705e-01 2 177212724 177212725 2 + 0.766 0.674 -0.378
ENSG00000170144 E009 8.8195827 0.0018618086 2.845698e-01 4.248163e-01 2 177212726 177212740 15 + 1.051 0.926 -0.461
ENSG00000170144 E010 14.6455330 0.0012394221 4.783148e-01 6.167412e-01 2 177212741 177212748 8 + 1.229 1.158 -0.250
ENSG00000170144 E011 84.0073280 0.0021400651 5.377351e-03 1.695413e-02 2 177212749 177212758 10 + 1.990 1.853 -0.460
ENSG00000170144 E012 92.7306715 0.0043313449 4.617504e-02 1.023592e-01 2 177212759 177212759 1 + 2.022 1.909 -0.378
ENSG00000170144 E013 200.0614395 0.0097994474 1.700086e-01 2.882011e-01 2 177212760 177212767 8 + 2.345 2.252 -0.312
ENSG00000170144 E014 254.1083427 0.0116003858 2.267205e-01 3.584791e-01 2 177212768 177212771 4 + 2.446 2.359 -0.292
ENSG00000170144 E015 772.5160933 0.0048039831 3.332796e-02 7.844300e-02 2 177212772 177212805 34 + 2.931 2.838 -0.311
ENSG00000170144 E016 734.6988092 0.0058931199 5.222311e-01 6.560770e-01 2 177212806 177212871 66 + 2.887 2.844 -0.141
ENSG00000170144 E017 1.2125718 0.2074385421 5.225940e-01 6.563745e-01 2 177213242 177213265 24 + 0.268 0.401 0.827
ENSG00000170144 E018 1.6544326 0.0261463139 8.774045e-01 9.252487e-01 2 177213266 177213275 10 + 0.433 0.397 -0.193
ENSG00000170144 E019 3.7893330 0.0071403171 6.286705e-01 7.441733e-01 2 177213276 177213300 25 + 0.645 0.707 0.263
ENSG00000170144 E020 8.5416563 0.0021107471 6.478698e-01 7.594797e-01 2 177213301 177213418 118 + 1.005 0.945 -0.220
ENSG00000170144 E021 2297.4604718 0.0008856697 1.026263e-09 1.519163e-08 2 177215539 177215661 123 + 3.413 3.300 -0.374
ENSG00000170144 E022 3084.2984335 0.0008472651 7.739358e-08 8.031762e-07 2 177215750 177215896 147 + 3.533 3.437 -0.321
ENSG00000170144 E023 1619.7876340 0.0015245836 1.813037e-02 4.740913e-02 2 177215978 177215989 12 + 3.241 3.174 -0.220
ENSG00000170144 E024 3847.0383569 0.0017462486 2.696114e-01 4.081203e-01 2 177215990 177216188 199 + 3.604 3.564 -0.135
ENSG00000170144 E025 36.4753819 0.0095492571 1.121844e-02 3.169015e-02 2 177216189 177216502 314 + 1.660 1.459 -0.685
ENSG00000170144 E026 2085.2859807 0.0030161600 7.859986e-01 8.629508e-01 2 177216503 177216525 23 + 3.332 3.305 -0.088
ENSG00000170144 E027 2770.9955017 0.0025460903 8.183276e-01 8.851860e-01 2 177216526 177216592 67 + 3.449 3.436 -0.044
ENSG00000170144 E028 22.3591581 0.0182910329 1.341315e-02 3.687644e-02 2 177216593 177216675 83 + 1.478 1.218 -0.904
ENSG00000170144 E029 2374.1873844 0.0019797444 1.612285e-01 2.766965e-01 2 177216676 177216726 51 + 3.369 3.384 0.050
ENSG00000170144 E030 1335.4203281 0.0011566892 1.385147e-02 3.789013e-02 2 177216727 177216747 21 + 3.111 3.145 0.113
ENSG00000170144 E031 979.3264927 0.0002966217 2.296920e-04 1.090615e-03 2 177216748 177216750 3 + 2.974 3.016 0.140
ENSG00000170144 E032 1185.9051834 0.0004188286 2.925509e-02 7.049912e-02 2 177216751 177216762 12 + 3.067 3.088 0.071
ENSG00000170144 E033 1049.9578486 0.0011543300 2.655597e-01 4.036286e-01 2 177216763 177216771 9 + 3.018 3.028 0.035
ENSG00000170144 E034 27.0218896 0.0109862549 5.574387e-03 1.748689e-02 2 177216772 177216859 88 + 1.546 1.294 -0.870
ENSG00000170144 E035 903.8270266 0.0009862942 6.233669e-01 7.399620e-01 2 177216860 177216862 3 + 2.959 2.957 -0.006
ENSG00000170144 E036 987.8504049 0.0013893607 7.217557e-01 8.160133e-01 2 177216863 177216877 15 + 2.998 2.994 -0.011
ENSG00000170144 E037 1109.0267433 0.0010745517 1.266120e-01 2.294281e-01 2 177216878 177216904 27 + 3.037 3.056 0.064
ENSG00000170144 E038 974.4474237 0.0020752436 5.363138e-01 6.680718e-01 2 177216905 177216907 3 + 2.987 2.994 0.022
ENSG00000170144 E039 1053.1013917 0.0017196812 6.162499e-01 7.343483e-01 2 177216908 177216913 6 + 3.023 3.026 0.011
ENSG00000170144 E040 1146.5120045 0.0008418664 1.173502e-01 2.161637e-01 2 177216914 177216934 21 + 3.053 3.070 0.057
ENSG00000170144 E041 973.1533357 0.0011794164 2.096757e-01 3.381719e-01 2 177216935 177216940 6 + 2.982 2.998 0.053
ENSG00000170144 E042 1252.5819661 0.0012813302 6.357482e-01 7.499507e-01 2 177217705 177217755 51 + 3.099 3.099 0.000
ENSG00000170144 E043 987.1993431 0.0004061661 3.321695e-01 4.757881e-01 2 177217756 177217800 45 + 3.008 2.984 -0.082
ENSG00000170144 E044 747.1136746 0.0014971441 8.637161e-01 9.161265e-01 2 177217801 177217806 6 + 2.882 2.869 -0.041
ENSG00000170144 E045 1354.9208790 0.0002954984 1.055216e-04 5.474220e-04 2 177217807 177217845 39 + 3.115 3.154 0.130
ENSG00000170144 E046 3079.0890577 0.0006017428 5.116049e-10 7.991590e-09 2 177219037 177219156 120 + 3.454 3.525 0.236
ENSG00000170144 E047 1890.5796298 0.0003953996 3.143148e-07 2.895669e-06 2 177219157 177219159 3 + 3.252 3.307 0.180
ENSG00000170144 E048 3570.4189246 0.0004955034 1.337679e-22 1.139475e-20 2 177219247 177219314 68 + 3.501 3.606 0.349
ENSG00000170144 E049 43.6646840 0.0006659467 1.788565e-06 1.406260e-05 2 177219315 177219407 93 + 1.758 1.483 -0.938
ENSG00000170144 E050 7445.1470557 0.0004061721 2.935957e-01 4.346729e-01 2 177219408 177221976 2569 + 3.874 3.872 -0.008
ENSG00000170144 E051 169.0466722 0.0066420027 6.058125e-22 4.794042e-20 2 177221977 177222059 83 + 2.405 1.891 -1.722
ENSG00000170144 E052 1844.3196152 0.0050880040 1.458454e-11 2.955709e-10 2 177222060 177223958 1899 + 3.370 3.114 -0.851