ENSG00000170142

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306627 ENSG00000170142 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2E1 protein_coding protein_coding 70.36687 45.62026 121.445 10.39233 3.715671 1.412359 44.495402 26.1176557 78.648659 5.4537370 1.3187654 1.59002791 0.61802500 0.57836667 0.64820000 0.06983333 2.888355e-01 2.582857e-06 FALSE TRUE
ENST00000424381 ENSG00000170142 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2E1 protein_coding protein_coding 70.36687 45.62026 121.445 10.39233 3.715671 1.412359 9.575627 12.9657006 13.334226 3.1934408 0.8697419 0.04040318 0.16265417 0.28340000 0.10960000 -0.17380000 2.582857e-06 2.582857e-06 FALSE TRUE
ENST00000442670 ENSG00000170142 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2E1 protein_coding protein_coding 70.36687 45.62026 121.445 10.39233 3.715671 1.412359 5.884498 1.3735536 16.065058 0.5011103 1.1595329 3.53837353 0.06041667 0.03680000 0.13206667 0.09526667 8.400668e-02 2.582857e-06 FALSE FALSE
ENST00000467766 ENSG00000170142 HEK293_OSMI2_2hA HEK293_TMG_2hB UBE2E1 protein_coding protein_coding 70.36687 45.62026 121.445 10.39233 3.715671 1.412359 3.864543 0.5191663 3.574274 0.1881669 0.3942738 2.75988804 0.05541667 0.01163333 0.02926667 0.01763333 6.635435e-02 2.582857e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170142 E001 0.5985731 2.055095e-02 8.310397e-01 8.940716e-01 3 23805740 23805819 80 + 0.207 0.181 -0.240
ENSG00000170142 E002 56.9258248 1.196134e-03 3.181347e-02 7.549468e-02 3 23805955 23805964 10 + 1.755 1.697 -0.198
ENSG00000170142 E003 57.1075292 1.373677e-03 4.117496e-02 9.320785e-02 3 23805965 23805965 1 + 1.755 1.701 -0.183
ENSG00000170142 E004 80.3412565 3.711241e-04 1.782643e-02 4.676670e-02 3 23805966 23805983 18 + 1.899 1.855 -0.151
ENSG00000170142 E005 96.3530614 4.269040e-04 2.710957e-02 6.621662e-02 3 23805984 23806088 105 + 1.973 1.943 -0.103
ENSG00000170142 E006 8.1242004 2.516630e-03 8.241286e-01 8.892026e-01 3 23807089 23807139 51 + 0.921 0.944 0.085
ENSG00000170142 E007 8.4614711 6.038210e-03 6.320608e-01 7.469777e-01 3 23807140 23807199 60 + 0.911 1.015 0.389
ENSG00000170142 E008 4.9176450 5.097975e-03 3.153023e-01 4.580547e-01 3 23807200 23807236 37 + 0.771 0.666 -0.429
ENSG00000170142 E009 269.8974756 1.767681e-04 1.415709e-09 2.040955e-08 3 23807237 23807329 93 + 2.434 2.347 -0.291
ENSG00000170142 E010 457.3169779 1.603236e-04 5.522140e-16 2.159242e-14 3 23807330 23807421 92 + 2.664 2.571 -0.308
ENSG00000170142 E011 0.0000000       3 23807422 23807888 467 +      
ENSG00000170142 E012 2.6312794 9.956340e-02 6.315203e-01 7.465019e-01 3 23808694 23808835 142 + 0.563 0.488 -0.359
ENSG00000170142 E013 3.2483765 5.070223e-03 1.751429e-01 2.948678e-01 3 23810157 23810320 164 + 0.669 0.488 -0.824
ENSG00000170142 E014 3.2336107 2.100353e-02 3.956917e-01 5.394856e-01 3 23810416 23810442 27 + 0.537 0.713 0.765
ENSG00000170142 E015 36.3235577 1.077112e-03 2.418449e-01 3.763589e-01 3 23810443 23810528 86 + 1.502 1.628 0.430
ENSG00000170142 E016 8.0810061 1.738195e-02 1.330132e-01 2.383060e-01 3 23810795 23811019 225 + 0.840 1.076 0.883
ENSG00000170142 E017 3.1315319 1.402987e-01 2.201231e-01 3.505697e-01 3 23811458 23811459 2 + 0.669 0.404 -1.254
ENSG00000170142 E018 466.6049408 4.707094e-04 2.607470e-06 1.979155e-05 3 23811460 23811510 51 + 2.657 2.618 -0.131
ENSG00000170142 E019 0.1515154 4.402447e-02 1.000000e+00   3 23866271 23866482 212 + 0.081 0.000 -8.346
ENSG00000170142 E020 813.0912480 5.987956e-04 3.800614e-03 1.258299e-02 3 23887567 23887699 133 + 2.885 2.889 0.014
ENSG00000170142 E021 6.0988954 2.752020e-03 9.754204e-01 9.886548e-01 3 23887700 23887789 90 + 0.813 0.859 0.177
ENSG00000170142 E022 3.8649070 1.726715e-01 1.549392e-01 2.683323e-01 3 23888238 23888261 24 + 0.741 0.411 -1.513
ENSG00000170142 E023 1071.8363880 9.447165e-05 2.375564e-02 5.931275e-02 3 23889112 23889259 148 + 2.997 3.029 0.105
ENSG00000170142 E024 12.4807755 1.394541e-03 6.726193e-01 7.785265e-01 3 23889260 23889426 167 + 1.101 1.112 0.038
ENSG00000170142 E025 2031.0357960 3.091731e-03 2.928902e-08 3.302612e-07 3 23890509 23891640 1132 + 3.226 3.376 0.498
ENSG00000170142 E026 4.7771396 5.260533e-02 2.993966e-01 4.409020e-01 3 23898004 23898057 54 + 0.669 0.884 0.859
ENSG00000170142 E027 2.0229379 7.722121e-03 2.638913e-02 6.472646e-02 3 23898293 23898399 107 + 0.305 0.711 2.023
ENSG00000170142 E028 0.1451727 4.416993e-02 1.000000e+00   3 23898400 23898425 26 + 0.081 0.000 -8.343
ENSG00000170142 E029 3.3266487 5.212103e-03 3.432824e-01 4.873303e-01 3 23900847 23901046 200 + 0.563 0.753 0.814