ENSG00000170037

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380262 ENSG00000170037 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTROB protein_coding protein_coding 30.29188 34.95728 23.05596 1.729263 0.5817382 -0.6002404 1.576950 1.534901 1.0770358 0.2366118 0.5544651 -0.5071148 0.05301667 0.04356667 0.04780000 0.004233333 9.049981e-01 7.25959e-30 FALSE TRUE
ENST00000563694 ENSG00000170037 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTROB protein_coding protein_coding 30.29188 34.95728 23.05596 1.729263 0.5817382 -0.6002404 11.821146 15.250100 8.1446138 1.3546392 0.5597732 -0.9040759 0.38487500 0.43786667 0.35286667 -0.085000000 4.029212e-01 7.25959e-30 FALSE TRUE
ENST00000565740 ENSG00000170037 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTROB protein_coding protein_coding 30.29188 34.95728 23.05596 1.729263 0.5817382 -0.6002404 2.592722 5.491901 1.9488372 1.1099044 0.9744520 -1.4899328 0.07964583 0.15600000 0.08410000 -0.071900000 7.027710e-01 7.25959e-30 FALSE TRUE
ENST00000570782 ENSG00000170037 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTROB protein_coding protein_coding 30.29188 34.95728 23.05596 1.729263 0.5817382 -0.6002404 2.315603 0.000000 3.4874743 0.0000000 0.4572529 8.4501696 0.08510417 0.00000000 0.15143333 0.151433333 7.259590e-30 7.25959e-30   FALSE
ENST00000571632 ENSG00000170037 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTROB protein_coding nonsense_mediated_decay 30.29188 34.95728 23.05596 1.729263 0.5817382 -0.6002404 2.043911 1.704786 1.5510907 0.2340449 0.1367051 -0.1354744 0.06913333 0.04833333 0.06763333 0.019300000 3.066559e-01 7.25959e-30 TRUE TRUE
ENST00000576922 ENSG00000170037 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTROB protein_coding retained_intron 30.29188 34.95728 23.05596 1.729263 0.5817382 -0.6002404 4.285860 4.076377 2.6189764 0.5631294 0.1442314 -0.6363211 0.14051667 0.11570000 0.11343333 -0.002266667 1.000000e+00 7.25959e-30 TRUE FALSE
MSTRG.13604.2 ENSG00000170037 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTROB protein_coding   30.29188 34.95728 23.05596 1.729263 0.5817382 -0.6002404 1.684061 1.578307 0.7729188 0.2354911 0.7729188 -1.0205553 0.05575000 0.04600000 0.03400000 -0.012000000 2.797119e-01 7.25959e-30 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170037 E001 0.6298062 0.0184075082 7.667568e-01 8.491595e-01 17 7932050 7932100 51 + 0.168 0.223 0.514
ENSG00000170037 E002 3.1344344 0.0299588422 5.143012e-02 1.116990e-01 17 7932101 7932138 38 + 0.791 0.479 -1.365
ENSG00000170037 E003 1.7370348 0.0086245561 2.492982e-01 3.850886e-01 17 7932155 7932205 51 + 0.526 0.327 -1.066
ENSG00000170037 E004 10.8645866 0.0018763180 5.094949e-03 1.619039e-02 17 7932206 7932241 36 + 1.206 0.925 -1.023
ENSG00000170037 E005 137.8584040 0.0006763876 5.603367e-10 8.704724e-09 17 7932242 7932460 219 + 2.231 2.031 -0.668
ENSG00000170037 E006 114.3652664 0.0002769297 3.027556e-06 2.263106e-05 17 7932461 7932546 86 + 2.124 1.966 -0.529
ENSG00000170037 E007 83.3339402 0.0004555136 1.908519e-04 9.248322e-04 17 7932547 7932578 32 + 1.981 1.832 -0.500
ENSG00000170037 E008 82.1138705 0.0023892917 6.620833e-03 2.024137e-02 17 7932579 7932610 32 + 1.955 1.831 -0.415
ENSG00000170037 E009 116.5198244 0.0020794543 1.411579e-02 3.848925e-02 17 7932611 7932692 82 + 2.087 1.991 -0.322
ENSG00000170037 E010 89.7875666 0.0008660913 2.374144e-01 3.711776e-01 17 7932693 7932762 70 + 1.941 1.894 -0.155
ENSG00000170037 E011 72.2827633 0.0004455953 5.180111e-01 6.523025e-01 17 7932763 7932800 38 + 1.791 1.824 0.111
ENSG00000170037 E012 116.5875122 0.0039436661 7.688725e-02 1.545159e-01 17 7932801 7932927 127 + 2.075 1.998 -0.258
ENSG00000170037 E013 87.9806140 0.0017136402 1.158183e-04 5.947156e-04 17 7932928 7932955 28 + 2.012 1.849 -0.549
ENSG00000170037 E014 152.0003088 0.0018255091 8.773172e-04 3.534625e-03 17 7932956 7933079 124 + 2.218 2.101 -0.389
ENSG00000170037 E015 71.5710842 0.0005475473 1.027003e-02 2.943147e-02 17 7933080 7933092 13 + 1.891 1.781 -0.373
ENSG00000170037 E016 89.1906507 0.0003357313 6.470689e-04 2.705658e-03 17 7933093 7933116 24 + 1.998 1.867 -0.440
ENSG00000170037 E017 203.8411866 0.0043526840 5.498943e-04 2.346408e-03 17 7933117 7933349 233 + 2.359 2.222 -0.457
ENSG00000170037 E018 132.2962911 0.0017355655 5.225792e-03 1.654540e-02 17 7934138 7934222 85 + 2.146 2.044 -0.342
ENSG00000170037 E019 136.4900341 0.0011215409 4.259619e-02 9.581259e-02 17 7934465 7934528 64 + 2.137 2.068 -0.231
ENSG00000170037 E020 97.8609352 0.0003476154 2.033098e-02 5.217898e-02 17 7934529 7934546 18 + 2.008 1.923 -0.286
ENSG00000170037 E021 5.9365895 0.0029978447 1.290570e-01 2.328653e-01 17 7934919 7934988 70 + 0.931 0.740 -0.747
ENSG00000170037 E022 193.7117188 0.0033331834 8.062997e-02 1.605422e-01 17 7934989 7935145 157 + 2.287 2.223 -0.214
ENSG00000170037 E023 4.3037585 0.0445193353 7.122981e-06 4.895615e-05 17 7935676 7936237 562 + 1.056 0.329 -3.194
ENSG00000170037 E024 18.0719710 0.0690911495 1.085157e-01 2.033630e-01 17 7936238 7936365 128 + 1.374 1.156 -0.767
ENSG00000170037 E025 176.2381967 0.0027361098 4.001808e-01 5.438815e-01 17 7936366 7936482 117 + 2.221 2.192 -0.096
ENSG00000170037 E026 197.4822405 0.0003672569 2.203656e-01 3.508438e-01 17 7936701 7936817 117 + 2.271 2.240 -0.104
ENSG00000170037 E027 142.8398314 0.0002671808 5.440358e-01 6.745419e-01 17 7937164 7937202 39 + 2.121 2.104 -0.055
ENSG00000170037 E028 108.9686220 0.0003704889 3.124275e-01 4.549598e-01 17 7937203 7937203 1 + 2.016 1.982 -0.114
ENSG00000170037 E029 164.0073677 0.0006034283 6.582196e-01 7.674132e-01 17 7937204 7937262 59 + 2.155 2.172 0.058
ENSG00000170037 E030 242.8710801 0.0001756496 1.366966e-01 2.434775e-01 17 7939513 7939689 177 + 2.310 2.351 0.136
ENSG00000170037 E031 157.2979802 0.0002766751 1.710365e-02 4.517320e-02 17 7939690 7939749 60 + 2.095 2.174 0.265
ENSG00000170037 E032 206.0948912 0.0002075707 3.915008e-04 1.742030e-03 17 7940096 7940242 147 + 2.192 2.295 0.343
ENSG00000170037 E033 202.3057699 0.0014562811 1.097335e-03 4.294826e-03 17 7943391 7943524 134 + 2.176 2.288 0.374
ENSG00000170037 E034 3.9597748 0.0289636516 2.072589e-01 3.352284e-01 17 7943525 7943599 75 + 0.792 0.593 -0.829
ENSG00000170037 E035 203.8331511 0.0001875896 3.023437e-03 1.033517e-02 17 7944123 7944248 126 + 2.201 2.287 0.287
ENSG00000170037 E036 42.0962614 0.0089484206 8.343637e-03 2.465070e-02 17 7944249 7944475 227 + 1.707 1.524 -0.623
ENSG00000170037 E037 231.3565001 0.0001702190 6.947034e-03 2.108585e-02 17 7944476 7944638 163 + 2.266 2.339 0.246
ENSG00000170037 E038 2.8605574 0.0105398443 2.366773e-01 3.703370e-01 17 7945331 7945727 397 + 0.383 0.594 1.050
ENSG00000170037 E039 345.7220644 0.0001757491 1.372727e-05 8.831723e-05 17 7945728 7945986 259 + 2.422 2.520 0.325
ENSG00000170037 E040 171.2684180 0.0035093310 5.420008e-02 1.166002e-01 17 7947571 7947623 53 + 2.130 2.215 0.286
ENSG00000170037 E041 237.4498132 0.0030687668 1.728974e-02 4.558470e-02 17 7947624 7947722 99 + 2.264 2.358 0.313
ENSG00000170037 E042 215.2583045 0.0050308232 1.595529e-02 4.263004e-02 17 7947916 7947979 64 + 2.207 2.320 0.376
ENSG00000170037 E043 368.8765766 0.0021372516 1.320746e-03 5.046111e-03 17 7948157 7948327 171 + 2.449 2.550 0.338
ENSG00000170037 E044 307.4070992 0.0007939760 7.373654e-06 5.048853e-05 17 7948487 7948619 133 + 2.354 2.475 0.404
ENSG00000170037 E045 27.5887057 0.0046147295 2.924065e-02 7.047120e-02 17 7948620 7948685 66 + 1.519 1.362 -0.543
ENSG00000170037 E046 30.4560408 0.0017936838 9.945608e-06 6.613709e-05 17 7948686 7949081 396 + 1.633 1.345 -0.988
ENSG00000170037 E047 51.7026878 0.0004745075 7.498921e-01 8.367090e-01 17 7949082 7949084 3 + 1.661 1.681 0.069
ENSG00000170037 E048 171.2536115 0.0032064528 1.771395e-02 4.651799e-02 17 7949085 7949137 53 + 2.116 2.218 0.342
ENSG00000170037 E049 128.1841383 0.0052070365 2.451952e-02 6.088885e-02 17 7949138 7949157 20 + 1.977 2.095 0.397
ENSG00000170037 E050 29.7119884 0.0060802479 6.097978e-03 1.886759e-02 17 7949158 7949384 227 + 1.572 1.372 -0.687
ENSG00000170037 E051 184.1925122 0.0052476990 1.247944e-02 3.468711e-02 17 7949385 7949920 536 + 2.131 2.254 0.410