ENSG00000170017

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306107 ENSG00000170017 HEK293_OSMI2_2hA HEK293_TMG_2hB ALCAM protein_coding protein_coding 11.44193 2.979349 17.55318 0.2792016 0.851397 2.554651 7.2144249 0.6661344 12.012869 0.22626954 0.5508343 4.152327 0.5112167 0.2396333 0.6882667 0.4486333 5.957906e-03 1.231042e-17 FALSE TRUE
ENST00000465413 ENSG00000170017 HEK293_OSMI2_2hA HEK293_TMG_2hB ALCAM protein_coding protein_coding 11.44193 2.979349 17.55318 0.2792016 0.851397 2.554651 0.4332233 1.6494447 0.000000 0.39530108 0.0000000 -7.374557 0.1371750 0.5399333 0.0000000 -0.5399333 1.231042e-17 1.231042e-17 FALSE TRUE
ENST00000472644 ENSG00000170017 HEK293_OSMI2_2hA HEK293_TMG_2hB ALCAM protein_coding protein_coding 11.44193 2.979349 17.55318 0.2792016 0.851397 2.554651 1.9020740 0.6115062 3.342608 0.09926995 0.2773824 2.431443 0.1569833 0.2040000 0.1902000 -0.0138000 9.233028e-01 1.231042e-17 FALSE TRUE
ENST00000486979 ENSG00000170017 HEK293_OSMI2_2hA HEK293_TMG_2hB ALCAM protein_coding protein_coding 11.44193 2.979349 17.55318 0.2792016 0.851397 2.554651 1.7003699 0.0000000 1.837262 0.00000000 1.0022961 7.529245 0.1781292 0.0000000 0.1017000 0.1017000 4.028114e-01 1.231042e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000170017 E001 6.2615607 0.0135603237 6.740212e-02 1.390367e-01 3 105366909 105366917 9 + 0.598 1.040 1.750
ENSG00000170017 E002 62.1055864 0.0008090907 2.544977e-03 8.897510e-03 3 105366918 105367342 425 + 1.576 1.534 -0.144
ENSG00000170017 E003 41.1248857 0.0008105134 9.479525e-04 3.781172e-03 3 105367343 105367481 139 + 1.408 1.272 -0.475
ENSG00000170017 E004 0.0000000       3 105439338 105439485 148 +      
ENSG00000170017 E005 0.0000000       3 105440812 105440865 54 +      
ENSG00000170017 E006 0.0000000       3 105513325 105513362 38 +      
ENSG00000170017 E007 48.9903838 0.0004702476 5.161356e-03 1.636779e-02 3 105520067 105520167 101 + 1.474 1.422 -0.179
ENSG00000170017 E008 98.0468992 0.0004156830 9.663398e-07 8.040679e-06 3 105524289 105524508 220 + 1.775 1.656 -0.405
ENSG00000170017 E009 0.3030308 0.3363038021 1.000000e+00   3 105524509 105525393 885 + 0.076 0.000 -8.503
ENSG00000170017 E010 0.1515154 0.0423650500 7.368051e-01   3 105531235 105531379 145 + 0.040 0.000 -7.497
ENSG00000170017 E011 62.4421784 0.0008392958 3.375196e-08 3.764842e-07 3 105532002 105532066 65 + 1.594 1.297 -1.025
ENSG00000170017 E012 0.1451727 0.0431618665 7.368150e-01   3 105533602 105533602 1 + 0.040 0.000 -7.496
ENSG00000170017 E013 66.4771369 0.0004108268 2.149071e-07 2.047551e-06 3 105533603 105533690 88 + 1.618 1.384 -0.802
ENSG00000170017 E014 95.9854778 0.0010677022 7.970618e-07 6.760733e-06 3 105534663 105534845 183 + 1.768 1.634 -0.456
ENSG00000170017 E015 68.0347692 0.0032301879 1.683482e-04 8.281333e-04 3 105539975 105540102 128 + 1.619 1.505 -0.389
ENSG00000170017 E016 70.9559395 0.0003546201 7.211997e-05 3.904916e-04 3 105541633 105541765 133 + 1.636 1.534 -0.347
ENSG00000170017 E017 0.4439371 0.0215745554 1.000000e+00 1.000000e+00 3 105544602 105545188 587 + 0.110 0.000 -9.081
ENSG00000170017 E018 0.4460135 0.0337329275 1.000000e+00 1.000000e+00 3 105545189 105545222 34 + 0.110 0.000 -9.081
ENSG00000170017 E019 72.4980026 0.0004834572 6.174281e-04 2.597369e-03 3 105545223 105545335 113 + 1.640 1.587 -0.182
ENSG00000170017 E020 80.9709477 0.0003217292 2.712021e-03 9.409277e-03 3 105547149 105547284 136 + 1.683 1.676 -0.022
ENSG00000170017 E021 72.0682960 0.0039585622 1.108152e-02 3.136230e-02 3 105547390 105547523 134 + 1.636 1.634 -0.009
ENSG00000170017 E022 65.5972780 0.0023540801 5.862796e-01 7.098675e-01 3 105550127 105550219 93 + 1.578 1.725 0.499
ENSG00000170017 E023 51.1235038 0.0030838932 5.744884e-01 7.002961e-01 3 105550220 105550259 40 + 1.473 1.612 0.475
ENSG00000170017 E024 46.9421765 0.0303203864 3.590995e-01 5.034363e-01 3 105552144 105552182 39 + 1.442 1.530 0.300
ENSG00000170017 E025 85.6264536 0.0003516554 2.686264e-01 4.071041e-01 3 105552468 105552585 118 + 1.693 1.814 0.409
ENSG00000170017 E026 1.7068604 0.0090177790 1.657788e-01 2.827155e-01 3 105552586 105553171 586 + 0.247 0.635 2.115
ENSG00000170017 E027 80.7907057 0.0003537666 8.040767e-02 1.601972e-01 3 105571852 105571964 113 + 1.673 1.751 0.265
ENSG00000170017 E028 584.7469674 0.0244298173 3.390228e-09 4.556066e-08 3 105574477 105576900 2424 + 2.462 2.934 1.574