ENSG00000169992

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000302926 ENSG00000169992 HEK293_OSMI2_2hA HEK293_TMG_2hB NLGN2 protein_coding protein_coding 14.10881 15.79297 11.46815 1.569571 0.9316473 -0.4613063 3.5951709 2.9864268 3.3060339 0.5788648 0.3024903 0.1462157 0.24839167 0.18580000 0.28806667 0.10226667 0.01805939 0.01805939 FALSE TRUE
ENST00000570940 ENSG00000169992 HEK293_OSMI2_2hA HEK293_TMG_2hB NLGN2 protein_coding protein_coding 14.10881 15.79297 11.46815 1.569571 0.9316473 -0.4613063 0.7294832 0.4557722 1.4286066 0.3636177 0.7146317 1.6269756 0.05259167 0.02826667 0.11556667 0.08730000 0.68434440 0.01805939 FALSE FALSE
ENST00000575301 ENSG00000169992 HEK293_OSMI2_2hA HEK293_TMG_2hB NLGN2 protein_coding protein_coding 14.10881 15.79297 11.46815 1.569571 0.9316473 -0.4613063 1.2372823 1.2294041 0.9968847 0.3277894 0.1239121 -0.2997482 0.08702917 0.07573333 0.08940000 0.01366667 0.84493772 0.01805939 FALSE TRUE
MSTRG.13564.3 ENSG00000169992 HEK293_OSMI2_2hA HEK293_TMG_2hB NLGN2 protein_coding   14.10881 15.79297 11.46815 1.569571 0.9316473 -0.4613063 2.7508016 3.9586361 0.8899095 1.1692897 0.4479369 -2.1407914 0.17428750 0.24783333 0.07186667 -0.17596667 0.38559568 0.01805939 FALSE TRUE
MSTRG.13564.4 ENSG00000169992 HEK293_OSMI2_2hA HEK293_TMG_2hB NLGN2 protein_coding   14.10881 15.79297 11.46815 1.569571 0.9316473 -0.4613063 2.3058817 4.0237209 1.9307915 0.3714281 0.9677903 -1.0554662 0.18601667 0.26076667 0.17983333 -0.08093333 0.79067437 0.01805939 FALSE TRUE
MSTRG.13564.5 ENSG00000169992 HEK293_OSMI2_2hA HEK293_TMG_2hB NLGN2 protein_coding   14.10881 15.79297 11.46815 1.569571 0.9316473 -0.4613063 1.3055721 0.0000000 0.9953426 0.0000000 0.5695753 6.6515435 0.09906250 0.00000000 0.08636667 0.08636667 0.15967387 0.01805939 FALSE TRUE
MSTRG.13564.6 ENSG00000169992 HEK293_OSMI2_2hA HEK293_TMG_2hB NLGN2 protein_coding   14.10881 15.79297 11.46815 1.569571 0.9316473 -0.4613063 1.9311974 3.0441870 1.8947914 0.0945822 0.4432707 -0.6811553 0.13225417 0.19560000 0.16616667 -0.02943333 0.78173964 0.01805939 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000169992 E001 0.0000000       17 7404646 7404647 2 +      
ENSG00000169992 E002 0.1451727 0.0428784931 3.289427e-01   17 7404648 7404648 1 + 0.131 0.000 -16.510
ENSG00000169992 E003 0.3268771 0.0287172518 7.631975e-01   17 7404649 7404657 9 + 0.131 0.114 -0.226
ENSG00000169992 E004 0.5085815 0.2351548166 8.677327e-01 9.189205e-01 17 7404658 7404659 2 + 0.131 0.205 0.783
ENSG00000169992 E005 6.4848849 0.0758460615 5.546155e-04 2.364317e-03 17 7404660 7404673 14 + 1.090 0.574 -2.041
ENSG00000169992 E006 9.8814594 0.0290804922 5.873769e-03 1.828076e-02 17 7404674 7404717 44 + 1.158 0.901 -0.946
ENSG00000169992 E007 12.7684202 0.0348450602 8.381757e-02 1.655268e-01 17 7404718 7404800 83 + 1.199 1.074 -0.448
ENSG00000169992 E008 13.9760316 0.0667892343 7.297161e-01 8.218512e-01 17 7404874 7405033 160 + 1.049 1.223 0.624
ENSG00000169992 E009 63.0256864 0.0043006223 1.944465e-01 3.193359e-01 17 7405034 7405355 322 + 1.764 1.808 0.150
ENSG00000169992 E010 47.3292795 0.0004669449 8.244397e-04 3.346639e-03 17 7405356 7405610 255 + 1.707 1.647 -0.206
ENSG00000169992 E011 13.5618675 0.0015256048 3.084487e-02 7.361570e-02 17 7407845 7408011 167 + 1.198 1.105 -0.332
ENSG00000169992 E012 26.3236159 0.0154520953 2.028213e-03 7.314518e-03 17 7408012 7408459 448 + 1.505 1.346 -0.551
ENSG00000169992 E013 20.6908315 0.0036052147 3.383381e-07 3.097378e-06 17 7408460 7408579 120 + 1.470 1.173 -1.039
ENSG00000169992 E014 32.0476533 0.0006306784 6.264344e-08 6.619227e-07 17 7408580 7408640 61 + 1.625 1.404 -0.757
ENSG00000169992 E015 48.6045762 0.0042982867 7.168218e-05 3.883321e-04 17 7408641 7408712 72 + 1.753 1.633 -0.407
ENSG00000169992 E016 49.5093570 0.0005249909 4.928254e-04 2.132822e-03 17 7412157 7412207 51 + 1.731 1.667 -0.216
ENSG00000169992 E017 111.2068919 0.0039751049 1.217406e-05 7.929103e-05 17 7414344 7414493 150 + 2.083 2.005 -0.260
ENSG00000169992 E018 126.9012937 0.0072250474 4.804585e-02 1.057135e-01 17 7414663 7414848 186 + 2.086 2.103 0.058
ENSG00000169992 E019 135.6371333 0.0038595755 2.991599e-03 1.023993e-02 17 7414956 7415148 193 + 2.131 2.122 -0.031
ENSG00000169992 E020 277.6433022 0.0021318519 1.461617e-03 5.512072e-03 17 7415511 7416107 597 + 2.417 2.444 0.089
ENSG00000169992 E021 1218.2723725 0.0072175353 3.238848e-10 5.242567e-09 17 7416926 7419860 2935 + 2.913 3.167 0.847