ENSG00000169967

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000344908 ENSG00000169967 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K2 protein_coding protein_coding 4.72265 0.8443108 8.472162 0.07519104 0.1645768 3.311599 0.9014794 0.0000000 2.694751 0.0000000 0.3472968 8.079352 0.10518333 0.0000000 0.3177667 0.31776667 6.322389e-07 6.322389e-07 FALSE TRUE
ENST00000409947 ENSG00000169967 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K2 protein_coding protein_coding 4.72265 0.8443108 8.472162 0.07519104 0.1645768 3.311599 0.9622411 0.2601301 0.000000 0.2601301 0.0000000 -4.755583 0.29540000 0.2692333 0.0000000 -0.26923333 4.913803e-01 6.322389e-07 FALSE TRUE
ENST00000682094 ENSG00000169967 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K2 protein_coding protein_coding 4.72265 0.8443108 8.472162 0.07519104 0.1645768 3.311599 2.3821292 0.5841807 5.777411 0.2039836 0.3279440 3.283944 0.54018333 0.7307667 0.6822333 -0.04853333 5.248517e-01 6.322389e-07 FALSE TRUE
MSTRG.19168.3 ENSG00000169967 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K2 protein_coding   4.72265 0.8443108 8.472162 0.07519104 0.1645768 3.311599 0.4768001 0.0000000 0.000000 0.0000000 0.0000000 0.000000 0.05922917 0.0000000 0.0000000 0.00000000   6.322389e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000169967 E001 2.872191 0.1566207663 5.833529e-02 1.237737e-01 2 127298668 127298729 62 - 0.356 0.890 2.413
ENSG00000169967 E002 715.836497 0.0049308743 3.841463e-15 1.345698e-13 2 127298730 127307403 8674 - 2.623 2.867 0.813
ENSG00000169967 E003 53.385686 0.0020669091 1.485707e-01 2.597267e-01 2 127307404 127307804 401 - 1.541 1.544 0.009
ENSG00000169967 E004 43.473576 0.0005243331 2.031414e-01 3.301580e-01 2 127308585 127308762 178 - 1.453 1.462 0.029
ENSG00000169967 E005 31.536456 0.0007402592 6.380370e-01 7.517753e-01 2 127314754 127314883 130 - 1.312 1.379 0.233
ENSG00000169967 E006 29.165857 0.0006475177 5.277463e-03 1.668725e-02 2 127317629 127317760 132 - 1.308 1.113 -0.690
ENSG00000169967 E007 41.455513 0.0052976997 6.598636e-03 2.018295e-02 2 127318169 127318317 149 - 1.453 1.300 -0.531
ENSG00000169967 E008 44.095568 0.0005138543 4.513476e-04 1.971921e-03 2 127322046 127322252 207 - 1.483 1.278 -0.711
ENSG00000169967 E009 25.760239 0.0009080444 1.794413e-03 6.581597e-03 2 127323902 127323994 93 - 1.265 0.999 -0.955
ENSG00000169967 E010 24.489697 0.0129836845 3.829958e-02 8.791108e-02 2 127324174 127324241 68 - 1.234 1.079 -0.554
ENSG00000169967 E011 25.042629 0.0007973919 7.368899e-03 2.217658e-02 2 127325728 127325807 80 - 1.247 1.041 -0.740
ENSG00000169967 E012 27.138232 0.0008526771 6.547566e-03 2.004848e-02 2 127326687 127326817 131 - 1.277 1.078 -0.708
ENSG00000169967 E013 28.554049 0.0006484046 3.229455e-05 1.905833e-04 2 127329921 127330008 88 - 1.312 0.902 -1.483
ENSG00000169967 E014 26.773015 0.0006951788 3.574920e-04 1.609082e-03 2 127330392 127330505 114 - 1.282 0.953 -1.185
ENSG00000169967 E015 22.297727 0.2006733828 1.067062e-01 2.006827e-01 2 127335870 127335969 100 - 1.204 0.954 -0.905
ENSG00000169967 E016 16.453251 0.0361941917 3.045754e-01 4.465945e-01 2 127337738 127337778 41 - 1.065 1.000 -0.237
ENSG00000169967 E017 23.286438 0.0017582732 1.419133e-01 2.506531e-01 2 127338932 127339050 119 - 1.203 1.145 -0.206
ENSG00000169967 E018 13.184227 0.0012840543 1.378339e-02 3.773279e-02 2 127343126 127343194 69 - 0.996 0.698 -1.159
ENSG00000169967 E019 0.147249 0.0444728610 7.629217e-01   2 127343195 127343229 35 - 0.044 0.000 -6.633
ENSG00000169967 E020 0.147249 0.0444728610 7.629217e-01   2 127385505 127385560 56 - 0.044 0.000 -6.633
ENSG00000169967 E021 23.667772 0.0029535480 2.850069e-03 9.824181e-03 2 127387452 127387975 524 - 1.228 0.953 -0.996
ENSG00000169967 E022 0.147249 0.0444728610 7.629217e-01   2 127388248 127388465 218 - 0.044 0.000 -6.633