ENSG00000169946

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000407775 ENSG00000169946 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFPM2 protein_coding protein_coding 1.268474 1.036294 2.323964 0.1053183 0.1633509 1.157493 0.7189952 0.5015896 1.6347476 0.1782926 0.1660447 1.684807 0.49772500 0.5273 0.71273333 0.1854333 8.270052e-01 1.846394e-05 FALSE TRUE
ENST00000517361 ENSG00000169946 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFPM2 protein_coding protein_coding 1.268474 1.036294 2.323964 0.1053183 0.1633509 1.157493 0.1766252 0.4894932 0.1656177 0.2461886 0.1656177 -1.508027 0.18358750 0.4357 0.06363333 -0.3720667 3.503555e-01 1.846394e-05 FALSE TRUE
ENST00000520492 ENSG00000169946 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFPM2 protein_coding protein_coding 1.268474 1.036294 2.323964 0.1053183 0.1633509 1.157493 0.1590865 0.0000000 0.0000000 0.0000000 0.0000000 0.000000 0.17264167 0.0000 0.00000000 0.0000000   1.846394e-05 FALSE TRUE
ENST00000522160 ENSG00000169946 HEK293_OSMI2_2hA HEK293_TMG_2hB ZFPM2 protein_coding processed_transcript 1.268474 1.036294 2.323964 0.1053183 0.1633509 1.157493 0.1802019 0.0000000 0.5095944 0.0000000 0.1048469 5.699314 0.09857917 0.0000 0.21676667 0.2167667 1.846394e-05 1.846394e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000169946 E001 0.5546650 0.0216077834 2.806015e-01 4.204561e-01 8 104590733 104590768 36 + 0.095 0.271 1.823
ENSG00000169946 E002 0.0000000       8 104703719 104703784 66 +      
ENSG00000169946 E003 0.0000000       8 104714846 104714975 130 +      
ENSG00000169946 E004 0.0000000       8 104827357 104827478 122 +      
ENSG00000169946 E005 0.0000000       8 104833325 104833445 121 +      
ENSG00000169946 E006 0.0000000       8 104895407 104895717 311 +      
ENSG00000169946 E007 0.0000000       8 104991624 104991669 46 +      
ENSG00000169946 E008 0.0000000       8 105246293 105246529 237 +      
ENSG00000169946 E009 10.9442428 0.0646960404 1.876216e-01 3.107567e-01 8 105318438 105318981 544 + 1.137 0.929 -0.762
ENSG00000169946 E010 0.0000000       8 105319543 105319754 212 +      
ENSG00000169946 E011 0.0000000       8 105358478 105358516 39 +      
ENSG00000169946 E012 0.0000000       8 105358517 105358637 121 +      
ENSG00000169946 E013 0.1482932 0.0412139762 2.754453e-01   8 105387146 105387925 780 + 0.000 0.156 10.854
ENSG00000169946 E014 0.1482932 0.0412139762 2.754453e-01   8 105414875 105415006 132 + 0.000 0.156 10.854
ENSG00000169946 E015 9.3745279 0.0026347171 4.691199e-02 1.036678e-01 8 105419144 105419302 159 + 1.080 0.849 -0.863
ENSG00000169946 E016 11.3623101 0.0227830016 5.373223e-02 1.157856e-01 8 105444280 105444381 102 + 1.168 0.922 -0.897
ENSG00000169946 E017 0.8909948 0.0135255453 3.050431e-01 4.470864e-01 8 105451558 105451764 207 + 0.347 0.156 -1.503
ENSG00000169946 E018 0.1482932 0.0412139762 2.754453e-01   8 105528884 105528969 86 + 0.000 0.156 10.854
ENSG00000169946 E019 10.7857985 0.0226451285 1.213533e-01 2.218579e-01 8 105561363 105561481 119 + 1.138 0.942 -0.717
ENSG00000169946 E020 9.3171077 0.0018228969 1.290922e-01 2.329177e-01 8 105634246 105634357 112 + 1.071 0.899 -0.640
ENSG00000169946 E021 0.0000000       8 105690890 105690935 46 +      
ENSG00000169946 E022 10.1347361 0.0423059484 1.761595e-01 2.962318e-01 8 105788718 105788924 207 + 1.115 0.918 -0.724
ENSG00000169946 E023 0.0000000       8 105788925 105789027 103 +      
ENSG00000169946 E024 0.0000000       8 105795756 105795897 142 +      
ENSG00000169946 E025 0.0000000       8 105796769 105796906 138 +      
ENSG00000169946 E026 10.7302111 0.0209880281 5.516420e-01 6.810531e-01 8 105798724 105798948 225 + 1.098 1.019 -0.285
ENSG00000169946 E027 136.8456478 0.0004791936 2.053318e-07 1.963828e-06 8 105801047 105804539 3493 + 2.096 2.183 0.290