ENSG00000169914

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375120 ENSG00000169914 HEK293_OSMI2_2hA HEK293_TMG_2hB OTUD3 protein_coding protein_coding 7.836199 4.930812 9.009255 0.5445998 0.1941151 0.8682602 3.4595241 1.36261842 5.9993539 0.30180083 0.2841175 2.130279 0.41319583 0.28100000 0.66546667 0.38446667 0.0001961463 0.0001961463 FALSE TRUE
ENST00000481686 ENSG00000169914 HEK293_OSMI2_2hA HEK293_TMG_2hB OTUD3 protein_coding processed_transcript 7.836199 4.930812 9.009255 0.5445998 0.1941151 0.8682602 0.5674368 0.37637380 0.0000000 0.21448244 0.0000000 -5.271925 0.06420833 0.07306667 0.00000000 -0.07306667 0.0777071167 0.0001961463   FALSE
MSTRG.446.2 ENSG00000169914 HEK293_OSMI2_2hA HEK293_TMG_2hB OTUD3 protein_coding   7.836199 4.930812 9.009255 0.5445998 0.1941151 0.8682602 0.1327457 0.00000000 0.4582127 0.00000000 0.4582127 5.549092 0.01820417 0.00000000 0.05250000 0.05250000 0.9258195833 0.0001961463 FALSE TRUE
MSTRG.446.3 ENSG00000169914 HEK293_OSMI2_2hA HEK293_TMG_2hB OTUD3 protein_coding   7.836199 4.930812 9.009255 0.5445998 0.1941151 0.8682602 0.9035266 0.06827673 1.4350239 0.06827673 0.3891578 4.206366 0.10970833 0.01436667 0.15793333 0.14356667 0.0303549358 0.0001961463 FALSE TRUE
MSTRG.446.4 ENSG00000169914 HEK293_OSMI2_2hA HEK293_TMG_2hB OTUD3 protein_coding   7.836199 4.930812 9.009255 0.5445998 0.1941151 0.8682602 1.1148365 2.64096775 0.1291384 0.76283035 0.1291384 -4.251926 0.18130833 0.51473333 0.01480000 -0.49993333 0.0016629502 0.0001961463 FALSE TRUE
MSTRG.446.9 ENSG00000169914 HEK293_OSMI2_2hA HEK293_TMG_2hB OTUD3 protein_coding   7.836199 4.930812 9.009255 0.5445998 0.1941151 0.8682602 1.1468989 0.36361446 0.6080075 0.36361446 0.1163427 0.726074 0.14854583 0.08886667 0.06713333 -0.02173333 0.4815574224 0.0001961463 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000169914 E001 1.2523021 0.0241709269 1.934872e-01 3.181576e-01 1 19882395 19882405 11 + 0.341 0.210 -0.942
ENSG00000169914 E002 1.5510666 0.0209920676 9.648707e-02 1.850926e-01 1 19882406 19882409 4 + 0.404 0.210 -1.305
ENSG00000169914 E003 9.8056724 0.0030911158 3.858506e-05 2.232480e-04 1 19882410 19882498 89 + 1.037 0.728 -1.188
ENSG00000169914 E004 7.7009705 0.0058116547 6.361234e-04 2.666515e-03 1 19882499 19882500 2 + 0.938 0.674 -1.044
ENSG00000169914 E005 10.4335040 0.0017818385 4.142263e-05 2.378959e-04 1 19882501 19882530 30 + 1.057 0.776 -1.068
ENSG00000169914 E006 13.0737305 0.0135214537 3.518764e-05 2.056198e-04 1 19882531 19882596 66 + 1.150 0.857 -1.083
ENSG00000169914 E007 7.2893132 0.0131484897 1.609439e-03 5.991304e-03 1 19882597 19882598 2 + 0.921 0.673 -0.982
ENSG00000169914 E008 22.1166066 0.0008733238 8.837402e-09 1.100230e-07 1 19882599 19882720 122 + 1.359 1.085 -0.967
ENSG00000169914 E009 11.5004783 0.0023530291 3.620250e-04 1.626807e-03 1 19882721 19882734 14 + 1.076 0.894 -0.678
ENSG00000169914 E010 24.4370133 0.0008990333 3.324674e-07 3.047167e-06 1 19890385 19890457 73 + 1.381 1.201 -0.629
ENSG00000169914 E011 29.3145533 0.0007104126 6.650255e-08 6.991902e-07 1 19890458 19890533 76 + 1.454 1.293 -0.561
ENSG00000169914 E012 32.5552438 0.0048865088 4.277391e-07 3.834834e-06 1 19894368 19894480 113 + 1.499 1.344 -0.534
ENSG00000169914 E013 47.3241679 0.0201178516 1.423616e-05 9.125664e-05 1 19897540 19897662 123 + 1.657 1.492 -0.564
ENSG00000169914 E014 0.2214452 0.0616327335 2.391402e-01   1 19897663 19897815 153 + 0.000 0.210 18.651
ENSG00000169914 E015 35.5291316 0.0470806585 3.269655e-02 7.719574e-02 1 19904267 19904374 108 + 1.504 1.488 -0.055
ENSG00000169914 E016 20.6228484 0.0240913591 1.826138e-01 3.044876e-01 1 19904375 19904398 24 + 1.249 1.335 0.301
ENSG00000169914 E017 35.8422472 0.0006270300 2.513639e-02 6.216078e-02 1 19904891 19904987 97 + 1.475 1.583 0.369
ENSG00000169914 E018 19.2618717 0.0014247469 2.030618e-02 5.212380e-02 1 19906432 19906437 6 + 1.236 1.279 0.151
ENSG00000169914 E019 45.8618526 0.0005816915 3.465467e-03 1.162665e-02 1 19906438 19906564 127 + 1.590 1.677 0.297
ENSG00000169914 E020 31.7921413 0.0009404399 2.417722e-03 8.514997e-03 1 19906565 19906616 52 + 1.447 1.488 0.144
ENSG00000169914 E021 2.5484330 0.0067967131 1.719702e-01 2.907640e-01 1 19906728 19906944 217 + 0.374 0.775 1.861
ENSG00000169914 E022 945.7318381 0.0170740678 1.323696e-09 1.917937e-08 1 19907570 19912945 5376 + 2.792 3.153 1.202