ENSG00000169895

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380155 ENSG00000169895 HEK293_OSMI2_2hA HEK293_TMG_2hB SYAP1 protein_coding protein_coding 25.41842 18.88863 36.36459 0.9339774 0.8823125 0.9446496 4.611179 4.225953 5.245296 0.4404870 0.1365489 0.3110854 0.1908958 0.2234667 0.1444000 -0.079066667 0.0173147 0.003054638 FALSE  
MSTRG.33946.2 ENSG00000169895 HEK293_OSMI2_2hA HEK293_TMG_2hB SYAP1 protein_coding   25.41842 18.88863 36.36459 0.9339774 0.8823125 0.9446496 13.386648 9.818552 19.079255 0.7642804 0.2829900 0.9577100 0.5214917 0.5184667 0.5250000 0.006533333 0.9472091 0.003054638 TRUE  
MSTRG.33946.5 ENSG00000169895 HEK293_OSMI2_2hA HEK293_TMG_2hB SYAP1 protein_coding   25.41842 18.88863 36.36459 0.9339774 0.8823125 0.9446496 6.830704 4.683677 10.708268 0.2222503 0.3175248 1.1912813 0.2616042 0.2491333 0.2944333 0.045300000 0.2963989 0.003054638 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000169895 E001 26.1309267 0.0017572542 0.0320360144 0.0759248251 X 16719612 16719636 25 + 1.495 1.331 -0.566
ENSG00000169895 E002 224.2018666 0.0002631087 0.1603424362 0.2755978363 X 16719637 16719770 134 + 2.337 2.361 0.079
ENSG00000169895 E003 359.3615250 0.0026951723 0.6006831017 0.7218874236 X 16719771 16719899 129 + 2.565 2.538 -0.087
ENSG00000169895 E004 404.0096402 0.0013477945 0.0536797278 0.1156896056 X 16735227 16735345 119 + 2.629 2.571 -0.191
ENSG00000169895 E005 371.9061672 0.0021989269 0.2648343368 0.4028267411 X 16736166 16736232 67 + 2.587 2.544 -0.141
ENSG00000169895 E006 1.8383034 0.0189731359 0.0884756918 0.1727913734 X 16736233 16736521 289 + 0.568 0.252 -1.782
ENSG00000169895 E007 386.6206567 0.0003968482 0.0888541281 0.1733660296 X 16741716 16741789 74 + 2.575 2.598 0.077
ENSG00000169895 E008 552.1553730 0.0002010211 0.0099269901 0.0285811321 X 16743701 16743840 140 + 2.725 2.755 0.101
ENSG00000169895 E009 615.9899086 0.0001208333 0.0825750655 0.1635726595 X 16754945 16755093 149 + 2.781 2.796 0.048
ENSG00000169895 E010 271.9320905 0.0001697304 0.3081406247 0.4503963161 X 16756663 16756664 2 + 2.428 2.440 0.039
ENSG00000169895 E011 450.5785027 0.0005943010 0.1788779904 0.2997358207 X 16756665 16756721 57 + 2.645 2.662 0.054
ENSG00000169895 E012 711.5017101 0.0009357619 0.1763943180 0.2965556584 X 16757162 16757309 148 + 2.843 2.858 0.051
ENSG00000169895 E013 263.5035672 0.0013225492 0.1478950219 0.2588173130 X 16760232 16760233 2 + 2.407 2.438 0.103
ENSG00000169895 E014 1363.0211644 0.0012995503 0.0001803852 0.0008796706 X 16760234 16763221 2988 + 3.164 3.092 -0.238
ENSG00000169895 E015 16.2740514 0.0743861321 0.6210363338 0.7380625803 X 16763222 16763397 176 + 1.255 1.200 -0.194
ENSG00000169895 E016 99.0086556 0.0002732405 0.3269989958 0.4704473596 X 16763398 16764856 1459 + 1.985 2.010 0.083
ENSG00000169895 E017 75.6989971 0.0113169729 0.0009977131 0.0039502958 X 16764857 16765340 484 + 1.775 1.990 0.724
ENSG00000169895 E018 0.1451727 0.0429860602 0.7027111393   X 16778170 16778198 29 + 0.104 0.000 -8.285