ENSG00000169855

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000464233 ENSG00000169855 HEK293_OSMI2_2hA HEK293_TMG_2hB ROBO1 protein_coding protein_coding 26.64196 13.38017 35.84502 0.4841515 1.528916 1.421001 5.316594 5.5155765 5.076253 0.5405465 0.8147920 -0.1195218 0.2482625 0.41090000 0.14130000 -0.26960000 2.802412e-06 3.762361e-17 FALSE TRUE
ENST00000466906 ENSG00000169855 HEK293_OSMI2_2hA HEK293_TMG_2hB ROBO1 protein_coding processed_transcript 26.64196 13.38017 35.84502 0.4841515 1.528916 1.421001 9.062237 4.0735729 11.948751 0.8703073 1.3619767 1.5501628 0.3392958 0.30093333 0.33143333 0.03050000 8.501823e-01 3.762361e-17 FALSE FALSE
ENST00000467549 ENSG00000169855 HEK293_OSMI2_2hA HEK293_TMG_2hB ROBO1 protein_coding protein_coding 26.64196 13.38017 35.84502 0.4841515 1.528916 1.421001 1.061733 0.0000000 2.999754 0.0000000 0.4445601 8.2335018 0.0280750 0.00000000 0.08303333 0.08303333 3.762361e-17 3.762361e-17 FALSE TRUE
ENST00000618846 ENSG00000169855 HEK293_OSMI2_2hA HEK293_TMG_2hB ROBO1 protein_coding protein_coding 26.64196 13.38017 35.84502 0.4841515 1.528916 1.421001 2.708731 3.3134036 2.931941 0.4300498 0.3557600 -0.1758934 0.1331833 0.25063333 0.08290000 -0.16773333 1.358459e-03 3.762361e-17 FALSE TRUE
MSTRG.23281.4 ENSG00000169855 HEK293_OSMI2_2hA HEK293_TMG_2hB ROBO1 protein_coding   26.64196 13.38017 35.84502 0.4841515 1.528916 1.421001 5.601838 0.2984459 10.371057 0.2984459 0.7798308 5.0727919 0.1692167 0.02396667 0.28926667 0.26530000 2.470859e-02 3.762361e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000169855 E001 1.2544010 0.0107552276 2.598710e-03 9.061287e-03 3 78597239 78597245 7 - 0.082 0.609 3.887
ENSG00000169855 E002 139.8561541 0.0123399237 3.947571e-20 2.549797e-18 3 78597246 78597457 212 - 1.821 2.428 2.033
ENSG00000169855 E003 504.6015153 0.0036396807 2.020191e-54 1.628592e-51 3 78597458 78598170 713 - 2.431 2.951 1.733
ENSG00000169855 E004 339.2852469 0.0001452374 2.238742e-68 3.165096e-65 3 78598171 78598687 517 - 2.341 2.714 1.242
ENSG00000169855 E005 134.3527374 0.0043399469 1.303236e-06 1.055960e-05 3 78598688 78598810 123 - 2.005 2.250 0.820
ENSG00000169855 E006 141.5828059 0.0057883701 1.216712e-03 4.696749e-03 3 78598811 78598927 117 - 2.056 2.240 0.615
ENSG00000169855 E007 213.1147195 0.0021651947 4.838591e-02 1.063024e-01 3 78600113 78600309 197 - 2.269 2.366 0.327
ENSG00000169855 E008 172.3025210 0.0024957730 3.230744e-01 4.664056e-01 3 78606733 78606807 75 - 2.189 2.259 0.232
ENSG00000169855 E009 269.2084842 0.0053827589 6.155458e-01 7.338047e-01 3 78606808 78607041 234 - 2.400 2.415 0.049
ENSG00000169855 E010 0.0000000       3 78607246 78607289 44 -      
ENSG00000169855 E011 170.8488994 0.0019166696 9.371738e-01 9.645116e-01 3 78614648 78614800 153 - 2.197 2.226 0.098
ENSG00000169855 E012 262.4080534 0.0023555731 9.277367e-01 9.585400e-01 3 78617635 78618041 407 - 2.382 2.412 0.098
ENSG00000169855 E013 117.5393725 0.0033109070 4.886658e-01 6.262050e-01 3 78627321 78627406 86 - 2.045 2.046 0.004
ENSG00000169855 E014 134.0373662 0.0067111365 6.308206e-01 7.459401e-01 3 78627407 78627569 163 - 2.099 2.109 0.033
ENSG00000169855 E015 135.1674490 0.0003479366 1.193465e-02 3.337541e-02 3 78631161 78631301 141 - 2.123 2.070 -0.178
ENSG00000169855 E016 73.3728983 0.0003635088 5.914123e-03 1.838460e-02 3 78631302 78631305 4 - 1.874 1.780 -0.316
ENSG00000169855 E017 0.3686942 0.0296796128 5.437011e-01 6.742637e-01 3 78633931 78633934 4 - 0.082 0.180 1.305
ENSG00000169855 E018 148.0877768 0.0002566736 1.205384e-04 6.164631e-04 3 78633935 78634042 108 - 2.173 2.079 -0.312
ENSG00000169855 E019 0.1451727 0.0431501831 1.000000e+00   3 78634428 78634580 153 - 0.082 0.000 -9.112
ENSG00000169855 E020 187.7503569 0.0030401349 1.090029e-04 5.634732e-04 3 78635773 78635943 171 - 2.281 2.163 -0.396
ENSG00000169855 E021 116.5983054 0.0002705594 1.869322e-03 6.820042e-03 3 78635944 78636108 165 - 2.066 1.985 -0.273
ENSG00000169855 E022 111.1239220 0.0017258382 1.902011e-01 3.140277e-01 3 78639744 78639898 155 - 2.026 2.004 -0.075
ENSG00000169855 E023 72.4900716 0.0004441125 4.128693e-02 9.340553e-02 3 78646148 78646190 43 - 1.857 1.795 -0.209
ENSG00000169855 E024 43.8049317 0.0010818130 8.122507e-03 2.409396e-02 3 78647629 78647655 27 - 1.663 1.534 -0.437
ENSG00000169855 E025 158.2586566 0.0002341969 8.899282e-10 1.331708e-08 3 78651732 78651929 198 - 2.223 2.059 -0.550
ENSG00000169855 E026 127.3762438 0.0036923004 4.436693e-06 3.195522e-05 3 78657098 78657269 172 - 2.134 1.954 -0.603
ENSG00000169855 E027 89.3336433 0.0003594263 1.345025e-04 6.790252e-04 3 78659686 78659800 115 - 1.965 1.835 -0.435
ENSG00000169855 E028 46.9469881 0.0010625809 1.441346e-01 2.536330e-01 3 78659801 78659807 7 - 1.665 1.612 -0.180
ENSG00000169855 E029 1.6432613 0.0768230832 1.584406e-02 4.238844e-02 3 78659939 78661025 1087 - 0.517 0.000 -12.575
ENSG00000169855 E030 0.6256415 0.0175438260 8.235517e-01 8.888272e-01 3 78661026 78661029 4 - 0.210 0.179 -0.283
ENSG00000169855 E031 121.1277345 0.0015632530 8.128756e-05 4.340751e-04 3 78661030 78661261 232 - 2.095 1.967 -0.428
ENSG00000169855 E032 95.4328840 0.0002934631 1.621265e-07 1.581864e-06 3 78661993 78662114 122 - 2.007 1.822 -0.623
ENSG00000169855 E033 115.7623591 0.0029551249 2.756007e-06 2.080231e-05 3 78667883 78668049 167 - 2.091 1.908 -0.612
ENSG00000169855 E034 109.9044721 0.0010526548 1.771268e-08 2.085657e-07 3 78668134 78668302 169 - 2.074 1.873 -0.675
ENSG00000169855 E035 1.0436561 0.0174627003 4.956008e-02 1.083818e-01 3 78668472 78668483 12 - 0.389 0.000 -11.920
ENSG00000169855 E036 80.8003537 0.0029363334 6.346639e-04 2.661052e-03 3 78668484 78668565 82 - 1.927 1.784 -0.481
ENSG00000169855 E037 129.1834068 0.0019421869 1.035862e-08 1.272887e-07 3 78670096 78670301 206 - 2.143 1.937 -0.690
ENSG00000169855 E038 0.0000000       3 78670302 78670540 239 -      
ENSG00000169855 E039 116.7252885 0.0077493701 5.235712e-04 2.247877e-03 3 78685746 78685917 172 - 2.090 1.928 -0.545
ENSG00000169855 E040 103.2682508 0.0022188322 1.020055e-07 1.034012e-06 3 78688648 78688772 125 - 2.049 1.836 -0.715
ENSG00000169855 E041 0.1515154 0.0429589044 1.000000e+00   3 78692888 78693347 460 - 0.082 0.000 -9.113
ENSG00000169855 E042 45.4613264 0.0211102121 1.298989e-02 3.588673e-02 3 78693348 78693356 9 - 1.695 1.502 -0.658
ENSG00000169855 E043 95.1621914 0.0129485199 3.699087e-06 2.714311e-05 3 78714397 78714524 128 - 2.032 1.740 -0.986
ENSG00000169855 E044 2.6323090 0.0499191429 5.696087e-01 6.961484e-01 3 78714525 78715257 733 - 0.488 0.611 0.570
ENSG00000169855 E045 114.7128266 0.0011097444 7.568470e-10 1.147997e-08 3 78717275 78717413 139 - 2.097 1.876 -0.741
ENSG00000169855 E046 106.8869923 0.0061631652 2.368792e-07 2.237984e-06 3 78717763 78717883 121 - 2.075 1.816 -0.870
ENSG00000169855 E047 105.9692849 0.0004266874 4.301913e-11 8.071552e-10 3 78746743 78746900 158 - 2.065 1.829 -0.792
ENSG00000169855 E048 150.2192077 0.0108395510 1.319891e-07 1.310325e-06 3 78938601 78938927 327 - 2.228 1.934 -0.986
ENSG00000169855 E049 203.5971763 0.0134426796 3.805669e-05 2.205281e-04 3 79018407 79019459 1053 - 2.345 2.122 -0.745
ENSG00000169855 E050 0.8042123 0.1146819506 6.491767e-01 7.605074e-01 3 79125456 79125539 84 - 0.262 0.180 -0.684
ENSG00000169855 E051 0.0000000       3 79512805 79512881 77 -      
ENSG00000169855 E052 0.0000000       3 79526492 79526576 85 -      
ENSG00000169855 E053 0.0000000       3 79527821 79527887 67 -      
ENSG00000169855 E054 0.0000000       3 79533014 79533109 96 -      
ENSG00000169855 E055 0.8157519 0.0162673303 6.521114e-01 7.628455e-01 3 79589824 79589961 138 - 0.210 0.306 0.717
ENSG00000169855 E056 0.9190056 0.0262100367 7.567433e-02 1.525850e-01 3 79767752 79767998 247 - 0.151 0.482 2.296