ENSG00000169813

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337970 ENSG00000169813 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPF protein_coding protein_coding 142.4498 108.3422 190.5314 17.11296 5.407174 0.8143761 90.555427 70.998681 113.92727 13.4034706 2.8100943 0.6821725 0.63974167 0.649533333 0.59850000 -5.103333e-02 0.41047691 0.03426296 FALSE  
ENST00000357065 ENSG00000169813 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPF protein_coding protein_coding 142.4498 108.3422 190.5314 17.11296 5.407174 0.8143761 7.684508 5.873516 10.34421 0.9227673 0.7348839 0.8154667 0.05256667 0.054233333 0.05420000 -3.333333e-05 1.00000000 0.03426296 FALSE  
ENST00000498176 ENSG00000169813 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPF protein_coding processed_transcript 142.4498 108.3422 190.5314 17.11296 5.407174 0.8143761 7.986065 3.635604 12.92671 1.8540291 2.1277580 1.8272407 0.05618333 0.039966667 0.06760000 2.763333e-02 0.76192722 0.03426296 FALSE  
ENST00000682386 ENSG00000169813 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPF protein_coding protein_coding 142.4498 108.3422 190.5314 17.11296 5.407174 0.8143761 19.736003 21.612452 30.22408 2.8351718 4.4633607 0.4836457 0.14382083 0.201466667 0.15950000 -4.196667e-02 0.52954913 0.03426296 FALSE  
MSTRG.3847.9 ENSG00000169813 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPF protein_coding   142.4498 108.3422 190.5314 17.11296 5.407174 0.8143761 8.949905 0.516130 12.28965 0.2919942 5.5360964 4.5470539 0.05397083 0.004266667 0.06343333 5.916667e-02 0.03426296 0.03426296 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000169813 E001 0.4439371 0.0215651085 1.564331e-01 2.703674e-01 10 43385617 43385617 1 - 0.254 0.000 -9.969
ENSG00000169813 E002 115.4509675 0.0108412938 4.683562e-05 2.657343e-04 10 43385618 43386021 404 - 1.921 2.201 0.938
ENSG00000169813 E003 2983.2224631 0.0010920400 1.305713e-20 8.972195e-19 10 43386022 43386858 837 - 3.397 3.555 0.524
ENSG00000169813 E004 2739.0530194 0.0012533611 6.293795e-01 7.447430e-01 10 43386859 43387338 480 - 3.422 3.456 0.114
ENSG00000169813 E005 2044.9896956 0.0001806513 3.645142e-06 2.678463e-05 10 43387339 43387588 250 - 3.319 3.309 -0.032
ENSG00000169813 E006 911.2810032 0.0004762596 4.043702e-05 2.327764e-04 10 43387589 43387632 44 - 2.977 2.944 -0.108
ENSG00000169813 E007 660.8811362 0.0006398896 2.161649e-03 7.725587e-03 10 43387633 43387642 10 - 2.834 2.809 -0.085
ENSG00000169813 E008 1786.0136608 0.0006290738 1.142879e-04 5.875578e-04 10 43387643 43387936 294 - 3.265 3.238 -0.089
ENSG00000169813 E009 704.0609927 0.0001277678 1.783671e-09 2.522666e-08 10 43394630 43394688 59 - 2.873 2.824 -0.164
ENSG00000169813 E010 849.5894767 0.0016804364 1.076281e-04 5.571903e-04 10 43396456 43396590 135 - 2.958 2.893 -0.216
ENSG00000169813 E011 70.1210189 0.0266082120 4.908613e-01 6.281899e-01 10 43396591 43396831 241 - 1.875 1.814 -0.204
ENSG00000169813 E012 36.4139836 0.0005911787 6.078889e-01 7.277771e-01 10 43397185 43397348 164 - 1.572 1.577 0.019
ENSG00000169813 E013 91.2711436 0.0003992850 1.228504e-01 2.240263e-01 10 43407717 43407928 212 - 1.979 1.957 -0.076
ENSG00000169813 E014 16.1878288 0.0011368390 9.028236e-01 9.421358e-01 10 43408727 43408882 156 - 1.234 1.259 0.088
ENSG00000169813 E015 23.7588242 0.0008932979 6.558546e-01 7.656736e-01 10 43409090 43409130 41 - 1.400 1.404 0.016
ENSG00000169813 E016 241.0582446 0.0006414807 1.177015e-06 9.630798e-06 10 43409131 43409186 56 - 2.425 2.332 -0.311