ENSG00000169783

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355300 ENSG00000169783 HEK293_OSMI2_2hA HEK293_TMG_2hB LINGO1 protein_coding protein_coding 13.86499 17.9392 15.15903 1.9797 0.6565345 -0.2427908 3.746956 6.543162 3.216443 0.06814951 0.1199082 -1.0222467 0.25475833 0.37556667 0.2125667 -0.16300000 0.02111318 0.02111318 FALSE TRUE
ENST00000557798 ENSG00000169783 HEK293_OSMI2_2hA HEK293_TMG_2hB LINGO1 protein_coding protein_coding 13.86499 17.9392 15.15903 1.9797 0.6565345 -0.2427908 3.861255 1.777170 6.483592 1.77717003 0.4657694 1.8613399 0.29752500 0.08773333 0.4266000 0.33886667 0.07104872 0.02111318 FALSE TRUE
ENST00000561030 ENSG00000169783 HEK293_OSMI2_2hA HEK293_TMG_2hB LINGO1 protein_coding protein_coding 13.86499 17.9392 15.15903 1.9797 0.6565345 -0.2427908 4.623674 7.245992 3.505757 1.40819147 0.3763725 -1.0453377 0.33540000 0.40560000 0.2300667 -0.17553333 0.08010558 0.02111318 FALSE TRUE
MSTRG.11288.3 ENSG00000169783 HEK293_OSMI2_2hA HEK293_TMG_2hB LINGO1 protein_coding   13.86499 17.9392 15.15903 1.9797 0.6565345 -0.2427908 1.124341 1.434981 1.551173 0.15381689 0.2874840 0.1115799 0.07667917 0.08086667 0.1042333 0.02336667 0.74761490 0.02111318 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000169783 E001 87.0283461 0.0209122325 0.0011102877 0.0043376366 15 77613027 77613669 643 - 1.696 2.008 1.050
ENSG00000169783 E002 117.5455256 0.0212038748 0.0011034379 0.0043144347 15 77613670 77614018 349 - 1.828 2.133 1.026
ENSG00000169783 E003 474.6256692 0.0050640405 0.0025488646 0.0089087997 15 77614019 77614943 925 - 2.558 2.697 0.462
ENSG00000169783 E004 319.4505677 0.0002641815 0.0008766833 0.0035327468 15 77614944 77615352 409 - 2.496 2.469 -0.091
ENSG00000169783 E005 173.4542359 0.0003739861 0.0003315589 0.0015069534 15 77615353 77615511 159 - 2.253 2.192 -0.203
ENSG00000169783 E006 68.5332717 0.0005806330 0.0190467406 0.0494382270 15 77615512 77615512 1 - 1.858 1.793 -0.219
ENSG00000169783 E007 117.4701360 0.0003912391 0.0052294915 0.0165560073 15 77615513 77615598 86 - 2.081 2.025 -0.186
ENSG00000169783 E008 79.8429130 0.0013576092 0.6019096544 0.7229624684 15 77615599 77615641 43 - 1.866 1.882 0.054
ENSG00000169783 E009 71.1859874 0.0004172141 0.0987019170 0.1885109895 15 77615642 77615672 31 - 1.848 1.815 -0.113
ENSG00000169783 E010 70.1269335 0.0049058147 0.0613800379 0.1289564836 15 77615673 77615721 49 - 1.858 1.800 -0.195
ENSG00000169783 E011 59.2787387 0.0039590623 0.0293139661 0.0706131644 15 77615722 77615781 60 - 1.800 1.722 -0.266
ENSG00000169783 E012 51.2038225 0.0169698479 0.5892405017 0.7123020817 15 77615782 77615832 51 - 1.689 1.692 0.011
ENSG00000169783 E013 37.1865136 0.0312702871 0.5926116374 0.7151315171 15 77615833 77615853 21 - 1.484 1.587 0.351
ENSG00000169783 E014 40.0961773 0.0188157838 0.5122221134 0.6471376830 15 77615854 77615876 23 - 1.518 1.618 0.341
ENSG00000169783 E015 36.9482816 0.0035473608 0.3832022322 0.5273878032 15 77615877 77615900 24 - 1.484 1.579 0.327
ENSG00000169783 E016 39.2587363 0.0025147207 0.0128624263 0.0355937492 15 77632310 77632912 603 - 1.647 1.535 -0.383
ENSG00000169783 E017 0.0000000       15 77634276 77634353 78 -      
ENSG00000169783 E018 9.3991326 0.0018716900 0.0836903816 0.1653273380 15 77677089 77677106 18 - 1.081 0.930 -0.556
ENSG00000169783 E019 7.4094064 0.0022372900 0.0256049898 0.0631308941 15 77677107 77677108 2 - 1.034 0.809 -0.852
ENSG00000169783 E020 13.2593842 0.0073885116 0.3085912610 0.4508741015 15 77677109 77677155 47 - 1.161 1.096 -0.236
ENSG00000169783 E021 11.6750849 0.0407552024 0.3003474219 0.4420179300 15 77677156 77677174 19 - 1.123 1.037 -0.312
ENSG00000169783 E022 26.1008437 0.0010609397 0.7170160108 0.8125166419 15 77690720 77690901 182 - 1.393 1.404 0.039
ENSG00000169783 E023 0.0000000       15 77695971 77696148 178 -      
ENSG00000169783 E024 0.0000000       15 77696391 77696495 105 -      
ENSG00000169783 E025 0.0000000       15 77707394 77707507 114 -      
ENSG00000169783 E026 10.4729064 0.0061279087 0.1908475754 0.3148090155 15 77715730 77715948 219 - 0.901 1.085 0.682
ENSG00000169783 E027 0.0000000       15 77720617 77720751 135 -      
ENSG00000169783 E028 18.4437574 0.0009965008 0.8975372511 0.9385890982 15 77734992 77735053 62 - 1.229 1.276 0.164
ENSG00000169783 E029 0.0000000       15 77786869 77787014 146 -      
ENSG00000169783 E030 17.8365512 0.0032653431 0.6212623863 0.7382522136 15 77795939 77796053 115 - 1.196 1.276 0.281
ENSG00000169783 E031 9.0754964 0.0019100075 0.0001991569 0.0009602139 15 77819271 77819713 443 - 1.185 0.826 -1.330
ENSG00000169783 E032 1.0610578 0.1099329468 0.3292966605 0.4727943162 15 77819934 77820033 100 - 0.420 0.248 -1.087
ENSG00000169783 E033 3.1260865 0.1971952679 0.7144476244 0.8106586548 15 77820034 77820257 224 - 0.586 0.576 -0.047
ENSG00000169783 E034 0.9943357 0.0127946818 0.1424301512 0.2513489932 15 77820258 77820332 75 - 0.421 0.181 -1.658
ENSG00000169783 E035 0.0000000       15 77820779 77820786 8 -      
ENSG00000169783 E036 0.0000000       15 77820787 77820842 56 -      
ENSG00000169783 E037 0.0000000       15 77820843 77820900 58 -