ENSG00000169762

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000405303 ENSG00000169762 HEK293_OSMI2_2hA HEK293_TMG_2hB TAPT1 protein_coding protein_coding 9.237659 2.975801 13.38874 0.06106509 0.640281 2.165908 3.3165849 2.22361775 4.9360852 0.19216604 0.04995513 1.146905 0.4216208 0.74773333 0.3707333 -0.37700000 1.581499e-03 4.810049e-17 FALSE TRUE
ENST00000503858 ENSG00000169762 HEK293_OSMI2_2hA HEK293_TMG_2hB TAPT1 protein_coding retained_intron 9.237659 2.975801 13.38874 0.06106509 0.640281 2.165908 1.7942349 0.23774396 1.7595673 0.23774396 1.00952194 2.836475 0.1863958 0.08210000 0.1248000 0.04270000 7.075509e-01 4.810049e-17 FALSE FALSE
ENST00000505603 ENSG00000169762 HEK293_OSMI2_2hA HEK293_TMG_2hB TAPT1 protein_coding nonsense_mediated_decay 9.237659 2.975801 13.38874 0.06106509 0.640281 2.165908 2.1240817 0.00000000 4.1714885 0.00000000 0.15777154 8.707873 0.1726667 0.00000000 0.3141333 0.31413333 4.810049e-17 4.810049e-17 FALSE TRUE
ENST00000513782 ENSG00000169762 HEK293_OSMI2_2hA HEK293_TMG_2hB TAPT1 protein_coding nonsense_mediated_decay 9.237659 2.975801 13.38874 0.06106509 0.640281 2.165908 0.5514481 0.04070073 0.9300049 0.04070073 0.19445576 4.212590 0.0540500 0.01313333 0.0709000 0.05776667 5.183368e-02 4.810049e-17 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000169762 E001 239.6466059 0.0002810330 1.000914e-15 3.778046e-14 4 16160505 16163251 2747 - 2.287 2.462 0.585
ENSG00000169762 E002 14.3904603 0.0292327439 1.548797e-01 2.682553e-01 4 16163252 16163260 9 - 1.092 1.254 0.577
ENSG00000169762 E003 28.8639608 0.0034954624 1.729881e-01 2.920801e-01 4 16163261 16163295 35 - 1.407 1.503 0.330
ENSG00000169762 E004 33.4946996 0.0006789774 5.701662e-01 6.966725e-01 4 16163296 16163346 51 - 1.489 1.524 0.120
ENSG00000169762 E005 27.4670988 0.0006863386 7.079197e-01 8.056819e-01 4 16163347 16163367 21 - 1.413 1.439 0.087
ENSG00000169762 E006 73.4769887 0.0003594336 8.517849e-01 9.080979e-01 4 16163368 16163537 170 - 1.836 1.842 0.023
ENSG00000169762 E007 47.2005254 0.0007164664 2.674772e-01 4.058041e-01 4 16166633 16166672 40 - 1.631 1.690 0.201
ENSG00000169762 E008 57.6122377 0.0006584618 1.010674e-01 1.920897e-01 4 16166673 16166793 121 - 1.713 1.792 0.268
ENSG00000169762 E009 1.3487633 0.1466572687 6.643904e-02 1.374587e-01 4 16166794 16166872 79 - 0.443 0.000 -13.679
ENSG00000169762 E010 39.5035327 0.0005909860 1.873741e-01 3.104336e-01 4 16170653 16170729 77 - 1.553 1.629 0.259
ENSG00000169762 E011 38.7047650 0.0005948039 5.921209e-01 7.147305e-01 4 16174204 16174272 69 - 1.578 1.544 -0.117
ENSG00000169762 E012 0.2944980 0.3657688484 7.930499e-01   4 16174273 16174548 276 - 0.144 0.000 -10.938
ENSG00000169762 E013 44.9741790 0.0004922040 5.570049e-01 6.855209e-01 4 16174670 16174729 60 - 1.641 1.606 -0.118
ENSG00000169762 E014 3.3129957 0.0074649166 3.601690e-01 5.044837e-01 4 16174730 16175041 312 - 0.656 0.499 -0.710
ENSG00000169762 E015 35.3548633 0.0006309009 2.320368e-01 3.648598e-01 4 16176119 16176150 32 - 1.550 1.471 -0.271
ENSG00000169762 E016 35.2646587 0.0005941805 2.318792e-01 3.646968e-01 4 16176151 16176193 43 - 1.550 1.471 -0.271
ENSG00000169762 E017 27.7840603 0.0007210244 1.822598e-02 4.762627e-02 4 16176194 16176228 35 - 1.478 1.299 -0.620
ENSG00000169762 E018 0.4375944 0.0253696104 3.977103e-01 5.414701e-01 4 16176478 16176790 313 - 0.201 0.000 -12.421
ENSG00000169762 E019 0.3332198 0.0318459374 4.547375e-01   4 16179393 16179489 97 - 0.078 0.188 1.461
ENSG00000169762 E020 0.8910940 0.2055508337 5.673107e-01 6.941370e-01 4 16179490 16179576 87 - 0.201 0.324 0.912
ENSG00000169762 E021 40.9141890 0.0005547443 8.642998e-01 9.165199e-01 4 16179577 16179657 81 - 1.594 1.583 -0.038
ENSG00000169762 E022 37.7009279 0.0007026223 2.973972e-01 4.387313e-01 4 16186535 16186604 70 - 1.576 1.509 -0.229
ENSG00000169762 E023 0.5975289 0.0307227209 2.545043e-01 3.911973e-01 4 16186605 16186780 176 - 0.252 0.000 -12.818
ENSG00000169762 E024 41.8207018 0.0004931509 3.447572e-01 4.888532e-01 4 16186781 16186878 98 - 1.615 1.557 -0.196
ENSG00000169762 E025 0.6287620 0.0182343327 3.243629e-01 4.677168e-01 4 16188217 16188219 3 - 0.144 0.318 1.459
ENSG00000169762 E026 22.6547889 0.0008917531 2.133665e-01 3.425041e-01 4 16188220 16188222 3 - 1.365 1.262 -0.359
ENSG00000169762 E027 23.6844999 0.0008122726 1.674815e-01 2.849225e-01 4 16188223 16188231 9 - 1.386 1.275 -0.389
ENSG00000169762 E028 25.3960500 0.0008156149 3.662688e-01 5.105964e-01 4 16188232 16188256 25 - 1.403 1.333 -0.245
ENSG00000169762 E029 29.0125452 0.0031172478 6.567556e-02 1.361765e-01 4 16188257 16188274 18 - 1.478 1.333 -0.499
ENSG00000169762 E030 40.9135701 0.0006256003 2.219032e-04 1.057556e-03 4 16188275 16188355 81 - 1.645 1.403 -0.828
ENSG00000169762 E031 0.1515154 0.0435678049 1.000000e+00   4 16190047 16190270 224 - 0.078 0.000 -10.827
ENSG00000169762 E032 0.8878743 0.0131335814 1.116914e-01 2.080454e-01 4 16190339 16191360 1022 - 0.338 0.000 -13.411
ENSG00000169762 E033 50.8052638 0.0004687143 2.727660e-03 9.455573e-03 4 16191361 16191523 163 - 1.722 1.551 -0.583
ENSG00000169762 E034 0.4460135 0.0299975790 3.975734e-01 5.413304e-01 4 16196658 16196723 66 - 0.201 0.000 -12.414
ENSG00000169762 E035 28.6016510 0.0023447152 2.348515e-01 3.681792e-01 4 16202462 16202538 77 - 1.457 1.365 -0.319
ENSG00000169762 E036 22.7890635 0.0046211951 5.462299e-02 1.173381e-01 4 16202539 16202580 42 - 1.383 1.208 -0.610
ENSG00000169762 E037 0.0000000       4 16202581 16202582 2 -      
ENSG00000169762 E038 24.0822654 0.0311418764 1.063345e-01 2.001406e-01 4 16213768 16213898 131 - 1.410 1.216 -0.678
ENSG00000169762 E039 0.1482932 0.0409748223 1.701343e-01   4 16214440 16214532 93 - 0.000 0.187 12.689
ENSG00000169762 E040 0.0000000       4 16214533 16214562 30 -      
ENSG00000169762 E041 0.4513240 0.2037147712 8.038954e-01 8.752217e-01 4 16214563 16214633 71 - 0.144 0.186 0.440
ENSG00000169762 E042 0.1451727 0.0433233063 1.000000e+00   4 16216074 16216170 97 - 0.078 0.000 -10.826
ENSG00000169762 E043 0.0000000       4 16225874 16226258 385 -      
ENSG00000169762 E044 17.6630175 0.0010463361 1.580967e-05 1.003550e-04 4 16226259 16226471 213 - 1.330 0.874 -1.654
ENSG00000169762 E045 0.0000000       4 16227309 16227410 102 -