ENSG00000169750

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306897 ENSG00000169750 HEK293_OSMI2_2hA HEK293_TMG_2hB RAC3 protein_coding protein_coding 322.6639 629.9819 166.7812 27.01432 5.211578 -1.91729 232.017314 463.601175 111.490811 18.408246 4.542289 -2.055861 0.70922500 0.736100000 0.66903333 -0.06706667 1.662534e-01 3.922402e-06 FALSE  
ENST00000580965 ENSG00000169750 HEK293_OSMI2_2hA HEK293_TMG_2hB RAC3 protein_coding protein_coding 322.6639 629.9819 166.7812 27.01432 5.211578 -1.91729 50.924052 100.749956 30.580848 1.918738 2.532347 -1.719750 0.16091250 0.160266667 0.18280000 0.02253333 4.348829e-01 3.922402e-06 FALSE  
MSTRG.15324.2 ENSG00000169750 HEK293_OSMI2_2hA HEK293_TMG_2hB RAC3 protein_coding   322.6639 629.9819 166.7812 27.01432 5.211578 -1.91729 8.273202 3.403957 9.392529 1.123117 2.435816 1.461604 0.02941667 0.005266667 0.05623333 0.05096667 3.922402e-06 3.922402e-06 FALSE  
MSTRG.15324.8 ENSG00000169750 HEK293_OSMI2_2hA HEK293_TMG_2hB RAC3 protein_coding   322.6639 629.9819 166.7812 27.01432 5.211578 -1.91729 20.009296 47.819503 4.469245 4.743725 2.441369 -3.416573 0.06007083 0.075533333 0.02726667 -0.04826667 5.741607e-01 3.922402e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000169750 E001 0.1482932 0.0416033783 1.000000e+00   17 82031573 82031604 32 + 0.001 0.063 7.031
ENSG00000169750 E002 15.5731960 0.0252888131 9.014280e-13 2.230867e-11 17 82031605 82031677 73 + 1.617 0.819 -2.853
ENSG00000169750 E003 1139.2771148 0.0044202279 1.008770e-03 3.988655e-03 17 82031678 82031796 119 + 3.011 2.904 -0.356
ENSG00000169750 E004 1.3403271 1.0358229600 4.631136e-01 6.029480e-01 17 82031876 82031903 28 + 0.484 0.235 -1.514
ENSG00000169750 E005 60.1957593 0.0068207523 2.519927e-01 3.883134e-01 17 82032043 82032060 18 + 1.712 1.635 -0.261
ENSG00000169750 E006 363.9347881 0.0050868330 8.914992e-01 9.347153e-01 17 82032061 82032183 123 + 2.420 2.429 0.030
ENSG00000169750 E007 1001.0148236 0.0012604181 4.579242e-02 1.016550e-01 17 82032184 82032386 203 + 2.901 2.859 -0.141
ENSG00000169750 E008 2839.5841634 0.0006306942 5.118388e-06 3.634420e-05 17 82032387 82032458 72 + 3.369 3.309 -0.199
ENSG00000169750 E009 28.6757753 0.0011382788 3.230883e-01 4.664186e-01 17 82032459 82032498 40 + 1.403 1.322 -0.280
ENSG00000169750 E010 4779.7631367 0.0001933050 7.283265e-02 1.480528e-01 17 82032711 82032828 118 + 3.556 3.543 -0.042
ENSG00000169750 E011 30.1314576 0.0007096906 2.476265e-12 5.698056e-11 17 82032878 82032946 69 + 1.712 1.235 -1.642
ENSG00000169750 E012 4313.9068166 0.0006651192 5.408494e-01 6.719235e-01 17 82032947 82033009 63 + 3.504 3.501 -0.012
ENSG00000169750 E013 6626.4813146 0.0003634759 3.119331e-03 1.061729e-02 17 82033440 82033599 160 + 3.663 3.692 0.097
ENSG00000169750 E014 275.2076320 0.0009815651 1.142572e-01 2.117476e-01 17 82033600 82033603 4 + 2.261 2.313 0.174
ENSG00000169750 E015 5449.4314389 0.0004915945 1.429474e-09 2.058449e-08 17 82033699 82034281 583 + 3.546 3.613 0.224