ENSG00000169696

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306739 ENSG00000169696 HEK293_OSMI2_2hA HEK293_TMG_2hB ASPSCR1 protein_coding protein_coding 41.43739 81.71853 19.61647 4.927829 1.017334 -2.058039 21.145254 48.683341 7.463000 4.1644792 1.80618982 -2.7039650 0.47400833 0.59403333 0.3761333 -0.21790000 1.447570e-01 4.428817e-10 FALSE  
ENST00000581647 ENSG00000169696 HEK293_OSMI2_2hA HEK293_TMG_2hB ASPSCR1 protein_coding protein_coding 41.43739 81.71853 19.61647 4.927829 1.017334 -2.058039 5.862866 10.930651 2.719296 1.0357701 0.05942796 -2.0030981 0.13959167 0.13350000 0.1392000 0.00570000 9.031673e-01 4.428817e-10 FALSE  
ENST00000583693 ENSG00000169696 HEK293_OSMI2_2hA HEK293_TMG_2hB ASPSCR1 protein_coding retained_intron 41.43739 81.71853 19.61647 4.927829 1.017334 -2.058039 1.988243 2.107145 1.484401 0.2524313 0.11559880 -0.5025532 0.05997083 0.02556667 0.0755000 0.04993333 4.428817e-10 4.428817e-10 TRUE  
MSTRG.15320.4 ENSG00000169696 HEK293_OSMI2_2hA HEK293_TMG_2hB ASPSCR1 protein_coding   41.43739 81.71853 19.61647 4.927829 1.017334 -2.058039 3.979471 7.035917 2.984486 0.5116610 0.32599517 -1.2344792 0.10117500 0.08596667 0.1522333 0.06626667 1.652381e-03 4.428817e-10 TRUE  
MSTRG.15320.5 ENSG00000169696 HEK293_OSMI2_2hA HEK293_TMG_2hB ASPSCR1 protein_coding   41.43739 81.71853 19.61647 4.927829 1.017334 -2.058039 1.817538 1.389241 2.110562 1.1237095 1.44566751 0.5998028 0.05945417 0.01766667 0.1116333 0.09396667 7.272105e-01 4.428817e-10 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000169696 E001 0.2965864 0.2309599335 1.000000e+00   17 81976807 81976979 173 + 0.001 0.112 7.724
ENSG00000169696 E002 0.0000000       17 81977550 81977550 1 +      
ENSG00000169696 E003 0.8481309 0.0143459250 2.388627e-01 3.728050e-01 17 81977551 81977557 7 + 0.382 0.162 -1.644
ENSG00000169696 E004 8.9005965 0.0019564649 6.440844e-01 7.564730e-01 17 81977558 81977601 44 + 0.906 0.846 -0.228
ENSG00000169696 E005 27.0412049 0.0131651944 2.875634e-01 4.280632e-01 17 81977602 81977628 27 + 1.385 1.286 -0.344
ENSG00000169696 E006 29.3566492 0.0095435546 2.400660e-01 3.742298e-01 17 81977629 81977630 2 + 1.421 1.319 -0.355
ENSG00000169696 E007 31.4798312 0.0190610520 3.876186e-01 5.317546e-01 17 81977631 81977633 3 + 1.433 1.354 -0.274
ENSG00000169696 E008 35.3817739 0.0342542813 8.052543e-01 8.761221e-01 17 81977634 81977640 7 + 1.433 1.413 -0.069
ENSG00000169696 E009 150.4976674 0.0049411064 2.539514e-01 3.905750e-01 17 81977641 81977704 64 + 2.072 2.023 -0.165
ENSG00000169696 E010 166.1011867 0.0018610022 4.565375e-01 5.969538e-01 17 81977705 81977748 44 + 2.092 2.068 -0.082
ENSG00000169696 E011 10.5421835 0.0250536035 5.219746e-02 1.130674e-01 17 81977899 81978054 156 + 1.136 0.882 -0.937
ENSG00000169696 E012 12.7877866 0.0084128304 4.357879e-03 1.414258e-02 17 81978055 81978185 131 + 1.253 0.939 -1.139
ENSG00000169696 E013 15.5803982 0.0050683486 2.698473e-01 4.083990e-01 17 81978186 81978339 154 + 1.179 1.062 -0.420
ENSG00000169696 E014 12.0222960 0.0172695313 7.256756e-02 1.476232e-01 17 81978340 81978804 465 + 1.158 0.939 -0.801
ENSG00000169696 E015 225.9251225 0.0009617150 7.912444e-01 8.665026e-01 17 81979184 81979239 56 + 2.207 2.204 -0.011
ENSG00000169696 E016 1.3588773 0.0166121993 5.414166e-03 1.705346e-02 17 81982614 81982676 63 + 0.655 0.162 -2.962
ENSG00000169696 E017 369.2495879 0.0011325835 2.046491e-01 3.319618e-01 17 81983554 81983668 115 + 2.442 2.413 -0.096
ENSG00000169696 E018 347.7222612 0.0002410713 2.046095e-01 3.319261e-01 17 81985507 81985607 101 + 2.413 2.386 -0.092
ENSG00000169696 E019 277.7860071 0.0004598845 8.365928e-01 8.978154e-01 17 81994821 81994878 58 + 2.283 2.295 0.038
ENSG00000169696 E020 44.6172816 0.0005090021 5.082219e-01 6.436807e-01 17 81994879 81994957 79 + 1.465 1.517 0.177
ENSG00000169696 E021 37.0369359 0.0006347328 1.275846e-01 2.307866e-01 17 81994958 81995150 193 + 1.317 1.446 0.448
ENSG00000169696 E022 0.1472490 0.0422755336 8.602126e-02   17 81995443 81995548 106 + 0.232 0.000 -12.994
ENSG00000169696 E023 217.0513349 0.0012391286 7.080449e-03 2.143619e-02 17 81995992 81996065 74 + 2.092 2.201 0.364
ENSG00000169696 E024 528.8320452 0.0008044575 3.021016e-07 2.793724e-06 17 81996420 81996846 427 + 2.455 2.591 0.454
ENSG00000169696 E025 20.0872163 0.0009647849 8.191869e-01 8.858319e-01 17 82004345 82006641 2297 + 1.199 1.180 -0.067
ENSG00000169696 E026 10.7926438 0.0348689176 3.940590e-01 5.379565e-01 17 82006642 82007434 793 + 0.822 0.967 0.554
ENSG00000169696 E027 27.4739080 0.0118194617 2.504929e-02 6.197532e-02 17 82007435 82009036 1602 + 1.089 1.349 0.920
ENSG00000169696 E028 148.2510539 0.0016641653 1.088942e-01 2.039090e-01 17 82009037 82009051 15 + 1.960 2.037 0.257
ENSG00000169696 E029 331.8537541 0.0020234292 2.630888e-01 4.009442e-01 17 82009052 82009191 140 + 2.338 2.381 0.143
ENSG00000169696 E030 295.8186888 0.0012348829 8.187829e-01 8.855029e-01 17 82009486 82009567 82 + 2.327 2.325 -0.006
ENSG00000169696 E031 2.4033726 0.0065949786 1.063809e-01 2.001962e-01 17 82009932 82010052 121 + 0.656 0.372 -1.381
ENSG00000169696 E032 179.0078419 0.0003308095 9.294304e-01 9.595847e-01 17 82010802 82010810 9 + 2.107 2.108 0.004
ENSG00000169696 E033 268.9863688 0.0002590224 1.843790e-01 3.067295e-01 17 82010811 82010868 58 + 2.245 2.289 0.148
ENSG00000169696 E034 295.1239836 0.0018287591 4.012986e-01 5.449964e-01 17 82011543 82011605 63 + 2.294 2.330 0.118
ENSG00000169696 E035 1.9604822 0.0126293024 5.404470e-02 1.163372e-01 17 82012084 82012155 72 + 0.656 0.312 -1.746
ENSG00000169696 E036 8.0908131 0.0281080126 8.110480e-01 8.801564e-01 17 82012156 82012230 75 + 0.866 0.833 -0.125
ENSG00000169696 E037 305.4539563 0.0041452924 3.998307e-02 9.100456e-02 17 82012231 82012283 53 + 2.257 2.352 0.317
ENSG00000169696 E038 18.5524474 0.0062588132 4.349161e-07 3.893099e-06 17 82012882 82013050 169 + 1.495 1.034 -1.625
ENSG00000169696 E039 96.4891663 0.0006500552 6.176416e-35 1.509811e-32 17 82013234 82015074 1841 + 2.211 1.719 -1.653
ENSG00000169696 E040 21.1040311 0.0009142168 3.994592e-12 8.874908e-11 17 82015075 82015213 139 + 1.607 1.062 -1.907
ENSG00000169696 E041 22.2917194 0.0008598680 9.634677e-09 1.192435e-07 17 82015214 82015356 143 + 1.568 1.115 -1.579
ENSG00000169696 E042 56.5014216 0.0004444014 1.961176e-15 7.134003e-14 17 82015357 82016193 837 + 1.929 1.517 -1.395
ENSG00000169696 E043 18.3359570 0.0009863496 1.784334e-03 6.549324e-03 17 82016194 82016308 115 + 1.372 1.089 -1.000
ENSG00000169696 E044 22.0854782 0.0011860487 2.828561e-03 9.759634e-03 17 82016309 82016475 167 + 1.421 1.167 -0.890
ENSG00000169696 E045 270.9345616 0.0017635052 1.743684e-02 4.590435e-02 17 82016476 82016527 52 + 2.207 2.300 0.310
ENSG00000169696 E046 23.8492236 0.0054408496 4.425610e-05 2.526042e-04 17 82016528 82016799 272 + 1.524 1.180 -1.197
ENSG00000169696 E047 282.2332812 0.0008420275 2.399093e-01 3.740287e-01 17 82016800 82016869 70 + 2.267 2.310 0.143
ENSG00000169696 E048 33.9015694 0.0040941480 1.714752e-05 1.079897e-04 17 82016870 82016940 71 + 1.643 1.330 -1.077
ENSG00000169696 E049 339.9608753 0.0021419221 3.226797e-04 1.471611e-03 17 82016941 82017088 148 + 2.269 2.403 0.448
ENSG00000169696 E050 117.9311516 0.0002539153 1.199150e-02 3.351118e-02 17 82017089 82017113 25 + 1.818 1.940 0.410
ENSG00000169696 E051 3.7201250 0.0043863196 8.811426e-03 2.581256e-02 17 82017114 82017133 20 + 0.000 0.619 14.247
ENSG00000169696 E052 119.9507644 0.0002544505 6.375019e-03 1.959770e-02 17 82017309 82017406 98 + 1.818 1.950 0.443