ENSG00000169689

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306704 ENSG00000169689 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPX protein_coding protein_coding 314.8394 675.0416 96.98649 34.16426 2.646097 -2.798993 185.27695 403.03718 47.89768 18.291362 1.509054 -3.072620 0.5744125 0.5974000 0.4937333 -0.10366667 2.500342e-11 2.500342e-11   FALSE
ENST00000392359 ENSG00000169689 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPX protein_coding protein_coding 314.8394 675.0416 96.98649 34.16426 2.646097 -2.798993 57.57788 126.65647 24.41423 5.831270 1.421570 -2.374649 0.1903625 0.1878333 0.2528333 0.06500000 8.625213e-02 2.500342e-11 FALSE FALSE
ENST00000580435 ENSG00000169689 HEK293_OSMI2_2hA HEK293_TMG_2hB CENPX protein_coding protein_coding 314.8394 675.0416 96.98649 34.16426 2.646097 -2.798993 40.57019 85.05453 13.93715 5.318964 1.138852 -2.608588 0.1225917 0.1259000 0.1434333 0.01753333 4.671630e-01 2.500342e-11   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000169689 E001 1.030954 7.002769e-01 4.715984e-01 6.106913e-01 17 82018702 82018702 1 - 0.285 0.179 -0.864
ENSG00000169689 E002 164.252179 2.381361e-04 2.940306e-01 4.351066e-01 17 82018703 82018715 13 - 2.018 1.978 -0.135
ENSG00000169689 E003 1124.300419 1.596437e-03 5.677169e-01 6.944814e-01 17 82018716 82018800 85 - 2.792 2.816 0.079
ENSG00000169689 E004 1592.123514 1.857906e-03 3.096964e-01 4.520356e-01 17 82018801 82018837 37 - 2.933 2.967 0.115
ENSG00000169689 E005 1267.092349 2.258239e-03 1.928169e-01 3.173033e-01 17 82018838 82018843 6 - 2.824 2.869 0.151
ENSG00000169689 E006 1377.391046 2.288290e-03 2.630682e-01 4.009323e-01 17 82018844 82018865 22 - 2.865 2.905 0.132
ENSG00000169689 E007 4910.073183 5.034049e-05 2.680691e-01 4.064840e-01 17 82018866 82019156 291 - 3.452 3.451 -0.005
ENSG00000169689 E008 2247.033934 4.365527e-04 3.018756e-01 4.436902e-01 17 82019157 82019219 63 - 3.091 3.114 0.078
ENSG00000169689 E009 97.083998 3.059966e-04 4.342468e-10 6.875617e-09 17 82019220 82019292 73 - 2.018 1.715 -1.019
ENSG00000169689 E010 1175.041173 7.013969e-04 1.856979e-03 6.779710e-03 17 82019293 82019307 15 - 2.762 2.837 0.250
ENSG00000169689 E011 2468.766864 8.578968e-04 5.848120e-01 7.086348e-01 17 82019308 82019381 74 - 3.137 3.155 0.061
ENSG00000169689 E012 45.100274 5.078691e-04 1.004037e-23 9.655422e-22 17 82019382 82019509 128 - 1.933 1.323 -2.078
ENSG00000169689 E013 82.309542 4.000697e-04 1.006880e-11 2.096158e-10 17 82019510 82019640 131 - 1.986 1.635 -1.184
ENSG00000169689 E014 575.415468 4.710957e-04 1.883876e-06 1.474284e-05 17 82019641 82019694 54 - 2.619 2.508 -0.369
ENSG00000169689 E015 21.157615 6.441980e-03 1.044913e-05 6.916691e-05 17 82019695 82019857 163 - 1.488 1.056 -1.519
ENSG00000169689 E016 1951.526715 5.350189e-04 2.795649e-01 4.193340e-01 17 82019858 82019909 52 - 3.027 3.053 0.087
ENSG00000169689 E017 154.409120 1.035065e-02 1.260762e-02 3.498577e-02 17 82022639 82022825 187 - 2.086 1.936 -0.503
ENSG00000169689 E018 1614.636814 7.159037e-04 8.721641e-01 9.217893e-01 17 82022826 82022918 93 - 2.964 2.969 0.018
ENSG00000169689 E019 1.507171 9.409939e-03 1.119851e-03 4.370002e-03 17 82024065 82024107 43 - 0.752 0.163 -3.350